Contratura isquêmica do miocárdio: estudo experimental em ratos

ischemic contracture of the heart (ich) has been largely employed for the investigation of global heart ischemia physiopathology. we herein describe a simple ich experimental model. eight wistar rats, anesthetized with sulfuric ether, were studied. the heart was rapidly removed by thoracotomy, and then immersed in a 37°c saline bath. a latex balloon catheter placed in the left ventricle and distended to 20 mmhg was used to detect ich onset (icho) and intensity (ichi). a 5 mmhg baseline elevation pepresented icho. ichi was represented by peak balloon pressure. ich dp/dt was calculated. the results (mean ± standard deviation) were similar to the literature: icho (min) = 15.5 ± 0.59; ichi (mmhg) = 62.0 ± 5.81; dp/dt (mmhg/min) = 14.2 ± 3.05.