Augmented visual feedback of movement performance to enhance walking recovery after stroke: study protocol for a pilot randomised controlled trial

Thikey Heather,Grealy Madeleine,van Wijck Frederike,Barber Mark

A randomized multicenter comparison of hybrid sirolimus-eluting stents with bioresorbable polymer versus everolimus-eluting stents with durable polymer in total coronary occlusion: rationale and design of the Primary Stenting of Occluded Native Coronary Arteries IV study

Teeuwen Koen,Adriaenssens Tom,Van den Branden Ben JL,Henriques José PS

Overview of the consortium of hospitals advancing research on tobacco (chart)

Riley William T,Stevens Victor J,Zhu Shu-Hong,Morgan Glen

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Efficiency and safety of inhalative sedation with sevoflurane in comparison to an intravenous sedation concept with propofol in intensive care patients: study protocol for a randomized controlled trial

Soukup Jens,Selle Antje,Wienke Andreas,Steighardt J？rg

Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial

Chang Anne B,Grimwood Keith,Robertson Colin F,Wilson Andrew C

Sponsors’ participation in conduct and reporting of industry trials: a descriptive study

Lundh Andreas,Krogsb？ll Lasse T,G？tzsche Peter C

Diagnostic randomized controlled trials: the final frontier

Rodger Marc,Ramsay Tim,Fergusson Dean

Development of a manualized protocol of massage therapy for clinical trials in osteoarthritis

Ali Ather,Kahn Janet,Rosenberger Lisa,Perlman Adam I

Practice effects in a longitudinal, multi-center Alzheimer’s disease prevention clinical trial

Abner Erin L,Dennis Brandon C,Mathews Melissa J,Mendiondo Marta S

PREVENTion of a parastomal hernia with a prosthetic mesh in patients undergoing permanent end-colostomy; the PREVENT-trial: study protocol for a multicenter randomized controlled trial

Brandsma Henk-Thijs,Hansson Birgitta ME,Haan Hilde V-Haaren-de,Aufenacker Theo J

School-based intervention to reduce anxiety in children: study protocol for a randomized controlled trial (PACES)

Stallard Paul,Taylor Gordon,Anderson Rob,Daniels Harry

The effects of reducing worry in patients with persecutory delusions: study protocol for a randomized controlled trial

Freeman Daniel,Dunn Graham,Startup Helen,Kingdon David

Comparing the effectiveness of copper intrauterine devices available in Canada. Is FlexiT non-inferior to NovaT when inserted immediately after first-trimester abortion? Study protocol for a randomized controlled trial

Norman Wendy V,Chiles Jessica L,Turner Caroline A,Brant Rollin

Treatment of adolescents with depression: the effect of transference interventions in a randomized controlled study of dynamic psychotherapy

Ulberg Randi,Hersoug Anne,H？glend Per

Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trial

Sanatinia Rahil,Barrett Barbara,Byford Sarah,Dean Madeleine

Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial

Bergese Sergio,Viloria Adolfo,Uribe Alberto,Antor Alejandra

Acupuncture, Counseling, and Usual care for Depression (ACUDep): study protocol for a randomized controlled trial

MacPherson Hugh,Richmond Stewart,Bland J,Lansdown Harriet

More Active Mums in Stirling (MAMMiS): a physical activity intervention for postnatal women. Study protocol for a randomized controlled trial

Gilinsky Alyssa S,Hughes Adrienne R,McInnes Rhona J

Impact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial

Boissonnat Pascale,Gaillard Ségolène,Mercier Catherine,Redonnet Michel

Quality of reporting of clinical non-inferiority and equivalence randomised trials - update and extension

Schiller Petra,Burchardi Nicole,Niestroj Michael,Kieser Meinhard

Depression care management for late-life depression in China primary care: Protocol for a randomized controlled trial

Shulin Chen, Yeates Conwell, Baihua Xu, Helen Chiu, Xin Tu, Yan Ma

Effects of acupuncture on patients with fibromyalgia: study protocol of a multicentre randomized controlled trial

Jorge Vas, Manuela Modesto, Inmaculada Aguilar, Koldo Santos-Rey, Nicolás Benítez-Parejo, Francisco Rivas-Ruiz

Study protocol for the recreational stimulation for elders as a vehicle to resolve delirium superimposed on dementia (Reserve For DSD) trial

Ann M Kolanowski, Donna M Fick, Mark S Litaker, Linda Clare, Doug Leslie, Malaz Boustani

Does treatment of subsyndromal depression improve depression and diabetes related outcomes: protocol for a randomised controlled comparison of psycho-education, physical exercise and treatment as usual

Mirjana Pibernik-Okanovi？, Dea Ajdukovi？, Marijana Lovren？i？, Norbert Hermanns

Study Protocol: Phase III single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease

Morag C Farquhar, A Toby Prevost, Paul McCrone, Irene J Higginson, Jennifer Gray, Barbara Brafman-Kennedy, Sara Booth

Simultaneous use of traditional Chinese medicine (Si-Ni-Tang) to treat septic shock patients: study protocol for a randomized controlled trial

Huang-Chi Chen, Wen-Chi Chen, Kai-Huang Lin, Yung-Hsiang Chen, Lun-Chien Lo, Tsung-Chieh Lee, Te-Chun Hsia, Chu-Hsien Wang, Shin-Hwar Wu, Hsin-Whae Hsu, Yu-Jun Chang, Yu-Chuen Huang, Tien-Hsiung Ku, Ming-Hwarng Horng

Intrathecal opioid versus ultrasound guided fascia iliaca plane block for analgesia after primary hip arthroplasty: study protocol for a randomised, blinded, noninferiority controlled trial

Rachel J Kearns, Alan JR Macfarlane, Keith J Anderson, John Kinsella

Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS)

Judi Edmans, Simon Conroy, Rowan Harwood, Sarah Lewis, Rachel A Elliott, Philippa Logan, Lucy Bradshaw, Matthew Franklin, John Gladman

Conservative management versus open reduction and internal fixation for mid-shaft clavicle fractures in adults - The Clavicle Trial: study protocol for a multicentre randomized controlled trial

Umile Longo, Sughran Banerjee, Julie Barber, Andrew Chambler, Carlos Cobiella, Steven Corbett, Mark Crowther, Steven Drew, Andrea Francis, Marcus Lee, Nicholas Garlick, Iain Packham, Yemi Pearse, Andrew Richards, Chris Roberts, Duncan Tennent, Emily Tims, Philip Ahrens

Impact of early parenteral nutrition completing enteral nutrition in adult critically ill patients (EPaNIC trial): a study protocol and statistical analysis plan for a randomized controlled trial

Micha？l P Casaer, Greet Hermans, Alexander Wilmer, Greet Van den Berghe

Randomized clinical trial comparing percutaneous closure of patent foramen ovale (PFO) using the Amplatzer PFO Occluder with medical treatment in patients with cryptogenic embolism (PC-Trial): rationale and design

Ahmed A Khattab, Stephan Windecker, Peter Jüni, David Hildick-Smith, Dariusz Dudek, Henning R Andersen, Reda Ibrahim, Gerhard Schuler, Antony S Walton, Andreas Wahl, Heinrich P Mattle, Bernhard Meier

A primary-school-based study to reduce prevalence of childhood obesity in Catalunya (Spain) - EDAL-Educació en alimentació: study protocol for a randomised controlled trial

Montse Giralt, Rosa Albaladejo, Lucia Tarro, David Mori？a, Victoria Arija, Rosa Solà

Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S - Scandinavian Starch for Severe Sepsis/Septic Shock trial): Study protocol, design and rationale for a double-blinded, randomised clinical trial

Anders Perner, Nicolai Haase, J？rn Wetterslev, Anders ？neman, Jyrki Tenhunen, Anne Guttormsen, Gudmundur Klemenzson, Frank Pott, Karen B？dker, Per B？dst？l？kken, Asger Bendtsen, Peter S？e-Jensen, Hamid Tousi, Morten Bestle, Malgorzata Pawlowicz, Robert Winding, Hans-Henrik Bülow, Claude Kancir, Morten Steensen, Jonas Nielsen, Bjarne Fogh, Kristian R Madsen, Nils H Larsen, Marcela Carlsson, J？rgen Wiis, John Petersen, Susanne Iversen, Ole Sch？idt, Siv Leivdal, Pawel Berezowicz

Detection of silent myocardial ischemia in asymptomatic patients with diabetes: results of a randomized trial and meta-analysis assessing the effectiveness of systematic screening

Michel M Lièvre, Philippe Moulin, Charles Thivolet, Michel Rodier, Vincent Rigalleau, Alfred Penfornis, Alain Pradignac, Michel Ovize, the DYNAMIT investigators

A randomized controlled trial examining Iyengar yoga for young adults with rheumatoid arthritis: a study protocol

Subhadra Evans, Laura Cousins, Jennie CI Tsao, Saskia Subramanian, Beth Sternlieb, Lonnie K Zeltzer

Randomised social-skills training and parental training plus standard treatment versus standard treatment of children with attention deficit hyperactivity disorder - The SOSTRA trial protocol

Ole Storeb？, Jesper Pedersen, Maria Skoog, Per Thomsen, Per Winkel, Christian Gluud, Erik Simonsen

A randomized controlled trial investigation of a non-stimulant in attention deficit hyperactivity disorder (ACTION): Rationale and design

Tracey W Tsang, Michael R Kohn, Daniel F Hermens, Simon D Clarke, C Richard Clark, Daryl Efron, Noel Cranswick, Chris Lamb, Leanne M Williams

Prevention of: self harm in British South Asian women: study protocol of an exploratory RCT of culturally adapted manual assisted Problem Solving Training (C- MAP)

Nusrat Husain, Nasim Chaudhry, Steevart V Durairaj, Imran Chaudhry, Sarah Khan, Meher Husain, Diwaker Nagaraj, Farooq Naeem, Waquas Waheed

Reducing the environmental impact of trials: a comparison of the carbon footprint of the CRASH-1 and CRASH-2 clinical trials

Saleena Subaiya, Euan Hogg, Ian Roberts

PRegnancy Outcomes after a Maternity Intervention for Stressful EmotionS (PROMISES): study protocol for a randomised controlled trial

Judith L Meijer, Claudi LH Bockting, Chantal Beijers, Tjitte Verbeek, A Stant, Johan Ormel, Ronald P Stolk, Peter de Jonge, Mari？lle G van Pampus, Huibert Burger

The effects of an Internet based self-help course for reducing panic symptoms - Don't Panic Online: study protocol for a randomised controlled trial

Wouter van Ballegooijen, Heleen Riper, Annemieke van Straten, Jeannet Kramer, Barbara Conijn, Pim Cuijpers

The UK clinical research network - has it been a success for dermatology clinical trials?

Kim S Thomas, Karin Koller, Katharine Foster, Jo Perdue, Lisa Charlesworth, Joanne R Chalmers

Empowerment of personal injury victims through the internet: design of a randomized controlled trial

Nieke A Elbers, Arno J Akkermans, Pim Cuijpers, David J Bruinvels

Clinical efficacy and prognostic indicators for lower limb pedalling exercise early after stroke: Study protocol for a pilot randomised controlled trial

Nicola J Hancock, Lee Shepstone, Philip Rowe, Phyo Myint, Valerie Pomeroy

The effect of five years versus two years of specialised assertive intervention for first episode psychosis - OPUS II: study protocol for a randomized controlled trial

Marianne Melau, Pia Jeppesen, Anne Thorup, Mette Bertelsen, Lone Petersen, Christian Gluud, Gertrud Krarup, Merete Nordentoft

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

Peter Connick, Madhan Kolappan, Rickie Patani, Michael A Scott, Charles Crawley, Xiao-Ling He, Karen Richardson, Kelly Barber, Daniel J Webber, Claudia AM Wheeler-Kingshott, Daniel J Tozer, Rebecca S Samson, David L Thomas, Ming-Qing Du, Shi L Luan, Andrew W Michell, Daniel R Altmann, Alan J Thompson, David H Miller, Alastair Compston, Siddharthan Chandran

Transfer of manualized Short Term Psychodynamic Psychotherapy (STPP) for social phobia into clinical practice: study protocol for a cluster-randomised controlled trial

J？rg Wiltink, Christian Ruckes, Antje Haselbacher, Marco Canterino, Falk Leichsenring, Peter Joraschky, Frank Leweke, Karin P？hlmann, Manfred E Beutel

Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trial

Quarraisha Karim, Ayesha BM Kharsany, Janet A Frohlich, Cheryl Baxter, Nonhlanhla Yende, Leila E Mansoor, Koleka P Mlisana, Silvia Maarschalk, Natasha Arulappan, Anneke Grobler, Sengeziwe Sibeko, Zaheen Omar, Tanuja N Gengiah, Mukelisiwe Mlotshwa, Natasha Samsunder, Salim S Abdool Karim

Prevention of hypertension in patients with pre-hypertension: protocol for the PREVER-prevention trial

Flávio D Fuchs, Sandra C Fuchs, Leila B Moreira, Miguel Gus, Ant？nio C Nóbrega, Carlos E Poli-de-Figueiredo, Décio Mion, Luiz Bortoloto, Fernanda Consolim-Colombo, Fernando Nobre, Eduardo Coelho, José F Vilela-Martin, Heitor Moreno, Evandro Cesarino, Roberto Franco, Andréa Brand？o, Marcos R de Sousa, Ant？nio Ribeiro, Paulo Jardim, Abrah？o Neto, Luiz Scala, Marco Mota, Hilton Chaves, Jo？o Alves, Dario Filho, Ricardo Pereira e Silva, José Neto, Maria Irigoyen, Iran Castro, André Steffens, Rosane Schlatter, Renato de Mello, Francisca Mosele, Flávia Ghizzoni, Otávio Berwanger