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ISSN: 2333-9721
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Genome Biology

ISSN Print: 1465-6906

ISSN Online:

主页: http://genomebiology.com

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Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast

Brian T Wilhelm, Samuel Marguerat, Sofia Aligianni, Sandra Codlin, Stephen Watt, Jürg B？hler

Dating the age of admixture via wavelet transform analysis of genome-wide data

Irina Pugach, Rostislav Matveyev, Andreas Wollstein, Manfred Kayser, Mark Stoneking

Genomewide characterization of non-polyadenylated RNAs

Li Yang, Michael O Duff, Brenton R Graveley, Gordon G Carmichael, Ling-Ling Chen

A top-down view on DNA replication and recombination from 9,000 feet above sea level

Erik Johansson, Christian Speck, Andrei Chabes

Vive la différence: biogenesis and evolution of microRNAs in plants and animals

Michael J Axtell, Jakub O Westholm, Eric C Lai

A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language

Ronny Herzog, Dominik Schwudke, Kai Schuhmann, Julio L Sampaio, Stefan R Bornstein, Michael Schroeder, Andrej Shevchenko

Coding potential of the products of alternative splicing in human

Guido Leoni, Loredana Le Pera, Fabrizio Ferrè, Domenico Raimondo, Anna Tramontano

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

Jordana T Bell, Athma A Pai, Joseph K Pickrell, Daniel J Gaffney, Roger Pique-Regi, Jacob F Degner, Yoav Gilad, Jonathan K Pritchard

The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics

Tara A Gianoulis, Ashish Agarwal, Michael Snyder, Mark B Gerstein

The transient receptor potential family of ion channels

Bernd Nilius, Grzegorz Owsianik

'Next-generation' sequencing becomes 'now-generation'

Daniel E Neafsey, Brian J Haas

Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content

Carina F Mugal, Hans Ellegren

Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study

Hiroki Goto, Benjamin Dickins, Enis Afgan, Ian M Paul, James Taylor, Kateryna D Makova, Anton Nekrutenko

Closure of the NCBI SRA and implications for the long-term future of genomics data storage

GB Editorial Team

Dynamic reprogramming of chromatin accessibility during Drosophila embryo development

Sean Thomas, Xiao-Yong Li, Peter J Sabo, Richard Sandstrom, Robert E Thurman, Theresa K Canfield, Erika Giste, William Fisher, Ann Hammonds, Susan E Celniker, Mark D Biggin, John A Stamatoyannopoulos

The role of codon selection in regulation of translation efficiency deduced from synthetic libraries

Sivan Navon, Yitzhak Pilpel

Bailing out

Gregory A Petsko

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

Wigard P Kloosterman, Marlous Hoogstraat, Oscar Paling, Masoumeh Tavakoli-Yaraki, Ivo Renkens, Joost S Vermaat, Markus J van Roosmalen, Stef van Lieshout, Isaac J Nijman, Wijnand Roessingh, Ruben van 't Slot, José van de Belt, Victor Guryev, Marco Koudijs, Emile Voest, Edwin Cuppen

SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing

Muhammad Tariq, John W Belmont, Seema Lalani, Teresa Smolarek, Stephanie M Ware

RNA-seq in grain unveils fate of neo- and paleopolyploidization events in bread wheat (Triticum aestivum L.)

Caroline Pont, Florent Murat, Carole Confolent, Sandrine Balzergue, Jér？me Salse

Composite effects of gene determinants on the translation speed and density of ribosomes

Tamir Tuller, Isana Veksler-Lublinsky, Nir Gazit, Martin Kupiec, Eytan Ruppin, Michal Ziv-Ukelson

Heat shock factor binding in Alu repeats expands its involvement in stress through an antisense mechanism

Rajesh Pandey, Amit K Mandal, Vineet Jha, Mitali Mukerji

Food of the dogs

Gregory A Petsko

Cistrome: an integrative platform for transcriptional regulation studies

Tao Liu, Jorge A Ortiz, Len Taing, Clifford A Meyer, Bernett Lee, Yong Zhang, Hyunjin Shin, Swee S Wong, Jian Ma, Ying Lei, Utz J Pape, Michael Poidinger, Yiwen Chen, Kevin Yeung, Myles Brown, Yaron Turpaz, X Shirley Liu

The relationship between proteome size, structural disorder and organism complexity

Eva Schad, Peter Tompa, Hedi Hegyi

Wrangling for microRNAs provokes much crosstalk

Ana C Marques, Jennifer Tan, Chris P Ponting

Accurate proteome-wide protein quantification from high-resolution 15N mass spectra

Zia Khan, Sasan Amini, Joshua S Bloom, Cristian Ruse, Amy A Caudy, Leonid Kruglyak, Mona Singh, David H Perlman, Saeed Tavazoie

Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera

Tom A Mendum, Jane Newcombe, Ahmad A Mannan, Andrzej M Kierzek, Johnjoe McFadden

The lamin protein family

Travis A Dittmer, Tom Misteli

Mapping of disease-associated variants in admixed populations

Daniel Shriner, Adebowale Adeyemo, Edward Ramos, Guanjie Chen, Charles N Rotimi

Bright days for yeast research

Martin P？evorovsky, Charalampos Rallis

The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue

Lee D Roberts, Andrew J Murray, David Menassa, Tom Ashmore, Andrew W Nicholls, Julian L Griffin

Metagenomic biomarker discovery and explanation

Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower

Alu elements: know the SINEs

Prescott Deininger

The blue marble

Gregory A Petsko

The draft genome and transcriptome of Cannabis sativa

Harm van Bakel, Jake M Stout, Atina G Cote, Carling M Tallon, Andrew G Sharpe, Timothy R Hughes, Jonathan E Page

Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity

Markus Rasmussen, Magnus Sundstr？m, Hanna Kultima, Johan Botling, Patrick Micke, Helgi Birgisson, Bengt Glimelius, Anders Isaksson

1, 2, 3: Counting the fingers on a chicken wing

Martin D Carkett, Malcolm PO Logan

Path finding methods accounting for stoichiometry in metabolic networks

Jon Pey, Joaquín Prada, John E Beasley, Francisco J Planes

An integrated strategy for identification of both sharp and broad peaks from next-generation sequencing data

Weiqun Peng, Keji Zhao

Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes

Peng Yao, Paul L Fox

Evaluation of genomic high-throughput sequencing data generated on Illumina HiSeq and Genome Analyzer systems

André E Minoche, Juliane C Dohm, Heinz Himmelbauer

Discovery of active enhancers through bidirectional expression of short transcripts

Michael F Melgar, Francis S Collins, Praveen Sethupathy

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila

Ana Garcia, Robert N Salomon, Alice Witsell, Justine Liepkalns, R Brent Calder, Moonsook Lee, Martha Lundell, Jan Vijg, Mitch McVey

A novel mode of chromosomal evolution peculiar to filamentous Ascomycete fungi

James K Hane, Thierry Rouxel, Barbara J Howlett, Gert HJ Kema, Stephen B Goodwin, Richard P Oliver

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells

Ishita S Mehta, Christopher H Eskiw, Halime D Arican, Ian R Kill, Joanna M Bridger

Single cell transcriptomics of neighboring hyphae of Aspergillus niger

Charissa de Bekker, Oskar Bruning, Martijs J Jonker, Timo M Breit, Han AB W？sten

A world in a grain of sand: human history from genetic data

Vincenza Colonna, Luca Pagani, Yali Xue, Chris Tyler-Smith

Tissue inhibitors of metalloproteinases

Gillian Murphy

Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing

Olivier Harismendy, Richard B Schwab, Lei Bao, Jeff Olson, Sophie Rozenzhak, Steve K Kotsopoulos, Stephanie Pond, Brian Crain, Mark S Chee, Karen Messer, Darren R Link, Kelly A Frazer

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