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ISSN: 2333-9721
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Molecular Neurodegeneration

ISSN Print: 1750-1326

ISSN Online:

主页: http://www.molecularneurodegeneration.com

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Establishment and evaluation of transgenic models of Alzheimer's disease with senescence accelerated background

Zhao Wenjuan,Lok KengHoe,Zhao Hong,Sun Anyang

Investigation of genetic variants regulating the expression of metabotropic glutamate receptor, subtype 5 (GRM5) mRNA in human brain

Wang Jian,Saffen David

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

Rogers Kathryn,Felsenstein Kevin M,Hrdlicka Lori,Tu Zhiming

Does axonopathy play a role in Parkinson's disease?

O’Malley Karen L,Antenor-Dorsey Jo Ann,Kim-Han Jeong Sook

Discovery of nitric oxide and cyclic GMP in cell signaling and their role in drug development

Murad Ferid

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

Torres Manuel,Jimenez Sebastian,Sanchez-Varo Raquel,Navarro Victoria

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL

Ren Haigang,Fu Kai,Mu Chenchen,Zhen Xuechu

Oxidative DNA damage triggers ProNGF-Mediated apoptosis in the striatum of 6-OHDA-treated rats

Wang Tao,Zuo Pingping,Chan Piu

EGCG and nimodipine improve the symptoms of AD by inhibiting [Ca2+]i in hippocampal neurons of APP/PS1 transgenic mice

Wang Shuang,Liu Mingyan,Zhang Zhenjie,Yao Weifan

Self-renewal potential of NPCs decreased in vitro during human embryonic brain development with reduced activation of mitogen-activated protein kinases signaling

Zhao Lingyu,Jiao Qian,Chen Xinlin,Yang Pengbo

Preventive effect of Curcumin on AD through increasing PS1/E-cadherin/beta-catenin complex mediated by E-cadherin

Zhang Xiong,Yin Wenke,Shi Xiaodong,Li Yu

Exploring the role of common regulatory variants in the etiology of late-onset Alzheimer’s disease

Wang Hao,Zhu Min,Wang Jian,Sun Yue

Gamma-secretase: from pathogenesis to therapeutics

Li Yueming

A tet-on system for Drd1a-expressing cells

Yao Fayi,MacKenzie Robert G

Gastrodin improves learning behavior in a rat model of Alzheimer's disease induced by intra-hippocampal Aβ 1-40 injection

Liu Xing,Wang Mengya

Curcumin protects brain from oxidative stress through inducing expression of UCP2 in chronic cerebral hypoperfusion aging-rats

Liu Li,Zhang Peng,Li Yu,Yu Gang

Acetylcholinesterase blocks cleavage of APP by γ-secretase in 293 cells and mouse brain

Niu Xin,Zhang Xuejin,Xie Jing,Zhang Xuejun

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

Chami Linda,Checler Frédéric

The roles of fractalkine signaling in neurodegenerative disease

Lamb Bruce

Epigenetic gambling & epigenetic drift as potential mechanisms underlying the quasi-stochastic distributions of late life neurodegenerative disorders

Martin George M

Deciphering the role of APP in synaptic function

Zheng Hui

Effects of nicotine on gastric myoelectrical activity in ICR mice

Wang Eileen,Du Sert Nathalie,Rudd John

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

Nübling Georg,Bader Benedikt,Levin Johannes,Hildebrandt Jenna

Protective effect of uric acid against 6-OHDA-induced injury in SH-SY5Y cells

Huang Tingting,Gong Li,Luo Weifeng,Hu Lifang

Beneficial effects of tri-lithium pyrroloquinoline quinonein on behaviors and pathology in a mouse model of Alzheimer’s disease

Zhao Lei,Gong Neng,Sun Xiaojing,Yu Zhe

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

McColl Gawain,Roberts Blaine R,Pukala Tara L,Kenche Vijaya B

Chinese herbal extract reduces Amyloid-β induced neurotoxicity through inhibiting NF-κB signaling pathway in neuronal cells

Wu Xuehua,Yu Yan,Zhou Liang,Wang Hecheng

The protective effects of TanIIA on neurotoxicity induced by β-amyloid protein through the Cdk5/P35 pathway in cultured primary neurons

Shi Lili,Yang Weina,Qian Yihua,Zhang Jianshui

Disruption of specific GDNF receptor subtype signaling impairs cortical neuronal survival in Alzheimer’s brains

Konishi Yoshihiro,Yang Libang,He Ping,Lindholm Kristina

DnaJB6: an indirect interaction protein of 15-kDa selenoprotein

Tian Jing,Liu Qiong,Ni Jiazuan

Some selenoproteins possibly involved in the development of Alzheimer’s disease: hints from the interaction proteins

Liu Qiong,Wang Chao,Qiao Xifeng,Chen Ping

Curcumin protects SH-SY5Y cells from oxidative stress by up-regulating HO-1 via Phosphatidylinositol 3 Kinase/Akt/Nrf-2 and down-regulating HO-2

Yin Wenke,Zhang Xiong,Shi Xiaodong,Li Yu

Alzheimer’s disease candidate gene PION is differentially expressed in human prefrontal cortex

Zhu Min,Saffen David

Curcumin preserves cognitive function and improve serum HDL in chronic cerebral hypoperfusion aging-rats

Tian Mingyuan,Wang Linhui,Yu Gang,Liu Bin

Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance

Ren Guijie,Ma Zonghcai,Hui Maria,Kudo Lili C

Aggregation of TDP-43 fragments triggers cellular aberrant function: implication in neurodegeneration

Che Meixia,Jiang Leilei,Zhou Chenjie,Jiang Yajun

The role of ATP-sensitive potassium channels on DMT1-mediated ferrous iron uptake in SK-N-SH cells

Du Xixun,Xu Huamin,Song Ning,Jiang Hong

Neuropathology of transgenic HD animal models

Li Xiaojiang,Li Shihua

Mass spectrometry quantification of clusterin in the human brain

Chen Junjun,Wang Meiyao,Turko Illarion V

The role of DJ-1 in anti-apoptosis

Ren Haigang,Fu Kai,Fan Jun,Wang Guanghui

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

Bauer Peter O,Hudec Roman,Goswami Anand,Kurosawa Masaru

Chronic cerebral hypoperfusion induces UCP2 expression by decreasing mitochondrial respiratory activities in aging rat brain

Gao Minna,Liu Li,Wang Linhui,Yu Gang

Protective effect of Curcumin on chronic cerebral ischemia by altering expression of α- synuclein in 2VO model

Yu Gang,Liu Li,Zhang Peng,Li Yu

Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells

Slowik Alexander,Merres Julika,Elfgen Anne,Jansen Sandra

Upregulation of astrocytic α7 nicotinic receptors in Alzheimer's disease brain- possible relevant to amyloid pathology

Yu Wenfeng,Mechawar Naguib,Krantic Slavica,Chabot Jean-Guy

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

Saito Yuhki,Inoue Tsuyoshi,Zhu Gang,Kimura Naoki

The study of the association of the p35 rs17852832 SNP polymorphism with Alzheimer’s disease

Shi Lili,Qian Yihua,Hu Xiaodan,Han Hua

EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation

Yang Ying,Shu Xiaogang,Liu Dan,Pei Lei

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

Chakrabarty Paramita,Tianbai Li,Herring Amanda,Ceballos-Diaz Carolina

β - but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

Tamayev Robert,Matsuda Shuji,D’Adamio Luciano

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