Molecular Cancer - oalib

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Molecular Cancer

ISSN Print: 1476-4598

ISSN Online:

主页: http://www.molecular-cancer.com

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The metabolic advantage of tumor cells

Maurice Isra？l, Laurent Schwartz

MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation

Yong-Xi Song, Zhen-Yu Yue, Zhen-Ning Wang, Ying-Ying Xu, Yang Luo, Hui-Mian Xu, Xue Zhang, Li Jiang, Cheng-Zhong Xing, Yong Zhang

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1

Hendrik Ungefroren, Stephanie Groth, Susanne Sebens, Hendrik Lehnert, Frank Gieseler, Fred F？ndrich

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

Gouji Toyokawa, Ken Masuda, Yataro Daigo, Hyun-Soo Cho, Masanori Yoshimatsu, Masashi Takawa, Shinya Hayami, Kazuhiro Maejima, Makoto Chino, Helen I Field, David E Neal, Eiju Tsuchiya, Bruce AJ Ponder, Yoshihiko Maehara, Yusuke Nakamura, Ryuji Hamamoto

Retinoic acid pathway activity in wilms tumors and characterization of biological responses in vitro

Jenny Wegert, Sabrina Bausenwein, Susanne Kneitz, Sabine Roth, Norbert Graf, Eva Geissinger, Manfred Gessler

Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth

Qiang Li, Mark E O'Malley, David L Bartlett, Z Sheng Guo

HCCS1-armed, quadruple-regulated oncolytic adenovirus specific for liver cancer as a cancer targeting gene-viro-therapy strategy

Hai-Neng Xu, Wei-Dan Huang, Ying Cai, Miao Ding, Jin-Fa Gu, Na Wei, Lan-Ying Sun, Xin Cao, Hua-Guang Li, Kang-Jian Zhang, Xin-Ran Liu, Xin-Yuan Liu

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

Hari Raghu, Christopher S Gondi, Dzung H Dinh, Meena Gujrati, Jasti S Rao

New Topoisomerase I mutations are associated with resistance to camptothecin

Céline Gongora, Nadia Vezzio-Vie, Sandie Tuduri, Vincent Denis, Annick Causse, Céline Auzanneau, Gwena？lle Collod-Beroud, Arnaud Coquelle, Philippe Pasero, Philippe Pourquier, Pierre Martineau, Maguy Del Rio

Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells

Wei-Lin W Wang, Namita Chatterjee, Sridar V Chittur, JoEllen Welsh, Martin P Tenniswood

Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells

Mingmei Liao, Jinfeng Zhao, Ton Wang, Jinghua Duan, Yangde Zhang, Xingming Deng

Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia

Hua Zhang, Xue-Qun Luo, Dan-Dan Feng, Xing-Ju Zhang, Jun Wu, Yu-Sheng Zheng, Xiao Chen, Ling Xu, Yue-Qin Chen

Side population rather than CD133+ cells distinguishes enriched tumorigenicity in hTERT-immortalized primary prostate cancer cells

Jianjun Zhou, Honghe Wang, Virginetta Cannon, Karen Wolcott, Hongbin Song, Clayton Yates

A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition

R Matthew Klein, Paul J Higgins

Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma

Qingjun Liu, James W Mier, David J Panka

MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma

Zuping Zhang, Hailin Tang, Zeyou Wang, Baoxin Zhang, Wei Liu, Hongmei Lu, Lan Xiao, Xiaoping Liu, Rong Wang, Xiaoling Li, Minghua Wu, Guiyuan Li

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

Italia A Asteriti, Maria Giubettini, Patrizia Lavia, Giulia Guarguaglini

Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH

Perry A Christian, Michael V Fiandalo, Steven R Schwarze

Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma

Danny CW Yu, Jonathan P Bury, James Tiernan, Jennifer S Waby, Carolyn A Staton, Bernard M Corfe

EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis

Xinyu Cao, Hu Zhu, Francis Ali-Osman, Hui-Wen Lo

The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1

Min-Kyoung Kim, Yoon-Kyung Jeon, Jong-Kyu Woo, Yun Choi, Dae-Han Choi, Yeul-Hong Kim, Chul-Woo Kim

Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells

Samina Alam, Brian S Bowser, Michael J Conway, Mohd Israr, Apurva Tandon, Craig Meyers

MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1

Peixin Dong, Masanori Kaneuchi, Hidemichi Watari, Junichi Hamada, Satoko Sudo, Jingfang Ju, Noriaki Sakuragi

Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells

Qi-En Wang, Keisha Milum, Chunhua Han, Yi-Wen Huang, Gulzar Wani, Jürgen Thomale, Altaf A Wani

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Adam Lister, Taoufik Nedjadi, Neil R Kitteringham, Fiona Campbell, Eithne Costello, Bryony Lloyd, Ian M Copple, Samantha Williams, Andrew Owen, John P Neoptolemos, Chris E Goldring, B Kevin Park

Antitumour effects of single or combined monoclonal antibodies directed against membrane antigens expressed by human B cells leukaemia

Séverine Loisel, Pierre-Alain André, Josee Golay, Franz Buchegger, Jean Kadouche, Martine Cérutti, Luca Bologna, Marek Kosinski, David Viertl, Angelika Delaloye, Christian Berthou, Jean-Pierre Mach, Laurence Boumsell

Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin

Ronan J Kelly, Ariel Lopez-Chavez, Deborah Citrin, John E Janik, John C Morris

c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

Mario Campone, Bélinda No？l, Cécile Couriaud, Morgan Grau, Yannis Guillemin, Fabien Gautier, Wilfried Gouraud, Catherine Charbonnel, Lo？c Campion, Pascal Jézéquel, Frédérique Braun, Benjamin Barré, Olivier Coqueret, Sophie Barillé-Nion, Philippe Juin

Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples

Shinji Mizuarai, Takumitsu Machida, Tsutomu Kobayashi, Hideya Komatani, Hiraku Itadani, Hidehito Kotani

Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression

Uddalak Bharadwaj, Christian Marin-Muller, Min Li, Changyi Chen, Qizhi Yao

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4

Hilmar M Warenius, Jeremy D Kilburn, Jon W Essex, Richard I Maurer, Jeremy P Blaydes, Usha Agarwala, Laurence A Seabra

A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

Elodie Grellier, Katia Lécolle, Sophie Rogée, Cyril Couturier, Jean-Claude D'Halluin, Saw-See Hong, Pascal Fender, Pierre Boulanger, Bruno Quesnel, Morvane Colin

Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism

Jason D Prescott, Joanna M Poczobutt, John J Tentler, Darius M Walker, Arthur Gutierrez-Hartmann

Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation

Kevin Vo, Barushi Amarasinghe, Kay Washington, Adriana Gonzalez, Jordan Berlin, Thao P Dang

Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer

Bao-Hong Guo, Yan Feng, Rong Zhang, Li-Hua Xu, Man-Zhi Li, Hsiang-Fu Kung, Li-Bing Song, Mu-Sheng Zeng

Sodium ion channel mutations in glioblastoma patients correlate with shorter survival

Avadhut D Joshi, D Parsons, Victor E Velculescu, Gregory J Riggins

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer

Sampoorna Satheesha, Victoria J Cookson, Louise J Coleman, Nicola Ingram, Brijesh Madhok, Andrew M Hanby, Charlotte AB Suleman, Vicky S Sabine, E Jane Macaskill, John MS Bartlett, J Michael Dixon, Jim N McElwaine, Thomas A Hughes

Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis

Yanfang Wang, Sylvia Shenouda, Somesh Baranwal, Rajamani Rathinam, Prachi Jain, Lili Bao, Siddhartha Hazari, Srikanta Dash, Suresh K Alahari

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

Zhihua Jiang, Ravindra Kamath, Shunquian Jin, Manimalha Balasubramani, Tej K Pandita, Baskaran Rajasekaran

Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin

Wei Wei, Mei-Sze Chua, Susan Grepper, Samuel K So

ZEB1 limits adenoviral infectability by transcriptionally repressing the Coxsackie virus and Adenovirus Receptor

Markus D Lacher, Marisa Shiina, Peter Chang, Debora Keller, Maarit I Tiirikainen, W Michael Korn

Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells

Sarah K Harten, Miguel A Esteban, Deepa Shukla, Margaret Ashcroft, Patrick H Maxwell

Targeting renal cell carcinoma with NVP-BEZ235, a dual PI3K/mTOR inhibitor, in combination with sorafenib

Didier Roulin, Laurent Waselle, Anne Dormond-Meuwly, Marc Dufour, Nicolas Demartines, Olivier Dormond

Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis

Inamul Haque, Smita Mehta, Monami Majumder, Kakali Dhar, Archana De, Douglas McGregor, Peter J Van Veldhuizen, Sushanta K Banerjee, Snigdha Banerjee

Improvement of different vaccine delivery systems for cancer therapy

Azam Bolhassani, Shima Safaiyan, Sima Rafati

Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression

Delphine Javelaud, Leon van Kempen, Vasileia I Alexaki, Erwan Le Scolan, Kunxin Luo, Alain Mauviel

Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells

Hideki Tatsukawa, Tetsuro Sano, Yayoi Fukaya, Naoto Ishibashi, Makiko Watanabe, Masataka Okuno, Hisataka Moriwaki, Soichi Kojima

Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy

Ivan Bièche, Sophie Vacher, Fran？ois Lallemand, Sengül Tozlu-Kara, Hind Bennani, Michèle Beuzelin, Keltouma Driouch, Etienne Rouleau, Florence Lerebours, Hugues Ripoche, Géraldine Cizeron-Clairac, Frédérique Spyratos, Rosette Lidereau

PIAS1 interacts with FLASH and enhances its co-activation of c-Myb

Anne Hege Alm-Kristiansen, Petra I Lorenzo, Ann-Kristin Molv？rsmyr, Vilborg Matre, Marit Ledsaak, Thomas S？ther, Odd S Gabrielsen

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