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PLOS ONE

ISSN Print: 1932-6203

ISSN Online:

主页: http://www.plosone.org/

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Insulin/IGF-I Signaling Pathways Enhances Tumor Cell Invasion through Bisecting GlcNAc N-glycans Modulation. An Interplay with E-Cadherin

Julio Cesar Madureira de-Freitas-Junior, Sandra Carvalho, Ana M. Dias, Patrícia Oliveira, Joana Cabral, Raquel Seruca, Carla Oliveira, José Andrés Morgado-Díaz, Celso A. Reis, Salomé S. Pinho

Timing of Surgical Intervention with Cochlear Implant in Patients with Large Vestibular Aqueduct Syndrome

Hui-Chen Ko, Tien-Chen Liu, Li-Ang Lee, Wei-Chieh Chao, Yung-Ting Tsou, Shu-Hang Ng, Che-Ming Wu

Effect of B-vitamin Supplementation on Stroke: a Meta-Analysis of Randomized Controlled Trials

Chi Zhang, Feng-Ling Chi, Tian-Hao Xie, Yu-Hao Zhou

The Autophagy-Related Marker LC3 Can Predict Prognosis in Human Hepatocellular Carcinoma

Yoo Jin Lee, Yu Jin Ha, Yu Na Kang, Koo Jeong Kang, Jae Seok Hwang, Woo Jin Chung, Kwang Bum Cho, Kyung Sik Park, Eun Soo Kim, Hye-Young Seo, Mi-Kyung Kim, Keun-Gyu Park, Byoung Kuk Jang

Changes in Physical Activity over Time in Young Children: A Longitudinal Study Using Accelerometers

Rachael W. Taylor, Sheila M. Williams, Victoria L. Farmer, Barry J. Taylor

Visual Search as a Tool for a Quick and Reliable Assessment of Cognitive Functions in Patients with Multiple Sclerosis

Kathrin S. Utz, Thomas M. A. Hankeln, Lena Jung, Alexandra L？mmer, Anne Waschbisch, De-Hyung Lee, Ralf A. Linker, Thomas Schenk

New Pyrazolopyrimidine Inhibitors of Protein Kinase D as Potent Anticancer Agents for Prostate Cancer Cells

Manuj Tandon, James Johnson, Zhihong Li, Shuping Xu, Peter Wipf, Qiming Jane Wang

Population Genetic Structure of Streptococcus pneumoniae in Kilifi, Kenya, Prior to the Introduction of Pneumococcal Conjugate Vaccine

Angela B. Brueggemann, Beth Mbesu Muroki, Benard W. Kulohoma, Angela Karani, Eva Wanjiru, Susan Morpeth, Tatu Kamau, Shahnaaz Sharif, J. Anthony G. Scott

Equine？Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMEL

Lisa S. Andersson, Maria Wilbe, Agnese Viluma, Gus Cothran, Bj？rn Ekesten, Susan Ewart, Gabriella Lindgren

Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody

Lei Wang, Yanran He, Ge Zhang, Juan Ma, Changzhen Liu, Wen He, Wei Wang, Huamin Han, Bhargavi M. Boruah, Bin Gao

Degeneration of Retinal ON Bipolar Cells Induced by Serum Including Autoantibody against TRPM1 in Mouse Model of Paraneoplastic Retinopathy

Shinji Ueno, Koji M. Nishiguchi, Hidetoshi Tanioka, Atsushi Enomoto, Takashi Yamanouchi, Mineo Kondo, Testuhiro R. Yasuma, Shunsuke Yasuda, Noriyuki Kuno, Masahide Takahashi, Hiroko Terasaki

Use of MSAP Markers to Analyse the Effects of Salt Stress on DNA Methylation in Rapeseed (Brassica napus var. oleifera)

Gianpiero Marconi, Roberta Pace, Alessandra Traini, Lorenzo Raggi, Stanley Lutts, Marialuisa Chiusano, Marcello Guiducci, Mario Falcinelli, Paolo Benincasa, Emidio Albertini

Structural Insights into the Mechanism for Recognizing Substrate of the Cytochrome P450 Enzyme TxtE

Feng Yu, Minjun Li, Chunyan Xu, Zhijun Wang, Huan Zhou, Min Yang, Yaxing Chen, Lin Tang, Jianhua He

A DNA Element Regulates Drug Tolerance and Withdrawal in Drosophila

Xiaolei Li, Alfredo Ghezzi, Jascha B. Pohl, Arun Y. Bohm, Nigel S. Atkinson

Functional Characterization of a Novel Frameshift Mutation in the C-terminus of the Nav1.5 Channel Underlying a Brugada Syndrome with Variable Expression in a Spanish Family

Pablo Dolz-Gaitón, Mercedes Nú？ez, Lucía Nú？ez, Adriana Barana, Irene Amorós, Marcos Matamoros, Marta Pérez-Hernández, Marta González de la Fuente, Miguel álvarez-López, Rosa Macías-Ruiz, Luis Tercedor-Sánchez, Juan Jiménez-Jáimez, Eva Delpón, Ricardo Caballero, Juan Tamargo

Comparison of the Prevalence of Common Bacterial Pathogens in the Oropharynx and Nasopharynx of Gambian Infants

Aderonke Odutola, Martin Antonio, Olumuyiwa Owolabi, Abdoulie Bojang, Ebenezer Foster-Nyarko, Simon Donkor, Ifedayo Adetifa, Sylvia Taylor, Christian Bottomley, Brian Greenwood, Martin Ota

The Origin of the RB1 Imprint

Deniz Kanber, Karin Buiting, Christian Roos, J？rg Gromoll, Sabine Kaya, Bernhard Horsthemke, Dietmar Lohmann

Prion-Seeding Activity in Cerebrospinal Fluid of Deer with Chronic Wasting Disease

Nicholas J. Haley, Alexandra Van de Motter, Scott Carver, Davin Henderson, Kristen Davenport, Davis M. Seelig, Candace Mathiason, Edward Hoover

DB-02, a C-6-Cyclohexylmethyl Substituted Pyrimidinone HIV-1 Reverse Transcriptase Inhibitor with Nanomolar Activity, Displays an Improved Sensitivity against K103N or Y181C Than S-DABOs

Xing-Jie Zhang, Li-He Lu, Rui-Rui Wang, Yue-Ping Wang, Rong-Hua Luo, Christopher Cong Lai, Liu-Meng Yang, Yan-Ping He, Yong-Tang Zheng

The Composition of Microbiome in Larynx and the Throat Biodiversity between Laryngeal Squamous Cell Carcinoma Patients and Control Population

Hong-Li Gong, Yi Shi, Liang Zhou, Chun-Ping Wu, Peng-Yu Cao, Lei Tao, Chen Xu, Dong-Sheng Hou, Yue-Zhu Wang

Genomic Stability of Aggregatibacter actinomycetemcomitans during Persistent Oral Infection in Human

Ruoxing Sun, Weerayuth Kittichotirat, Justin Wang, Minnie Jan, Weizhen Chen, Sirkka Asikainen, Roger Bumgarner, Casey Chen

Dissecting the Characteristics and Dynamics of Human Protein Complexes at Transcriptome Cascade Using RNA-Seq Data

Geng Chen, Jiwei Chen, Caiping Shi, Leming Shi, Weida Tong, Tieliu Shi

Variation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach

Derryck Klarkowski, Kathryn Glass, Daniel O’Brien, Kamalini Lokuge, Erwan Piriou, Leslie Shanks

Native Prey and Invasive Predator Patterns of Foraging Activity: The Case of the Yellow-Legged Hornet Predation at European Honeybee Hives

Karine Monceau, Mariangela Arca, Lisa Leprêtre, Florence Mougel, Olivier Bonnard, Jean-Fran？ois Silvain, Nevile Maher, Gérard Arnold, Denis Thiéry

The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease

Elisabeth Kapaki, George P. Paraskevas, Evangelia Emmanouilidou, Kostas Vekrellis

Diminished Memory T-Cell Expansion Due to Delayed Kinetics of Antigen Expression by Lentivectors

Karina Furmanov, Mazal Elnekave, Abdallah Sa'eed, Hadas Segev, Luba Eli-Berchoer, Darrell N. Kotton, Gilad Bachrach, Avi-Hai Hovav

Chemokine Expression in Inflamed Adipose Tissue Is Mainly Mediated by NF-κB

Franck Tourniaire, Beatrice Romier-Crouzet, Jong Han Lee, Julie Marcotorchino, Erwan Gouranton, Jerome Salles, Christiane Malezet, Julien Astier, Patrice Darmon, Eric Blouin, Stephane Walrand, Jianping Ye, Jean-Francois Landrier

Behavioural and Brain Gene Expression Profiling in Pigs during Tail Biting Outbreaks – Evidence of a Tail Biting Resistant Phenotype

Emma Brunberg, Per Jensen, Anders Isaksson, Linda J. Keeling

Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry

Jen-Chyong Wang, Noah Spiegel, Sarah Bertelsen, Nhung Le, Nicholas McKenna, John P. Budde, Oscar Harari, Manav Kapoor, Andrew Brooks, Dana Hancock, Jay Tischfield, Tatiana Foroud, Laura J. Bierut, Joe Henry Steinbach, Howard J. Edenberg, Bryan J. Traynor, Alison M. Goate

A Species Flock Driven by Predation? Secondary Metabolites Support Diversification of Slugs in Antarctica

Nerida G. Wilson, J. Alan Maschek, Bill J. Baker

Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis

Xinyi Leng, Ka Sing Wong, Yannie Soo, Thomas Leung, Xinying Zou, Yongjun Wang, Edward Feldmann, Liping Liu, David S. Liebeskind

Occurrence of Nodular Lymphocyte-Predominant Hodgkin Lymphoma in Hermansky-Pudlak Type 2 Syndrome Is Associated to Natural Killer and Natural Killer T Cell Defects

Luisa Lorenzi, Giovanna Tabellini, William Vermi, Daniele Moratto, Fulvio Porta, Lucia D. Notarangelo, Ornella Patrizi, Silvano Sozzani, Genevieve de Saint Basile, Sylvain Latour, David Pace, Silvia Lonardi, Fabio Facchetti, Raffaele Badolato, Silvia Parolini

Next-Generation Sequencing-Based Transcriptome Analysis of Helicoverpa armigera Larvae Immune-Primed with Photorhabdus luminescens TT01

Zengyang Zhao, Gongqing Wu, Jia Wang, Chunlin Liu, Lihong Qiu

The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice

P. Padmini S. J Khedoe, Man C. Wong, Gerry T. M. Wagenaar, Jaap J. Plomp, Miranda van Eck, Louis M. Havekes, Patrick C. N. Rensen, Pieter S. Hiemstra, Jimmy F. P. Berbée

Continuous and High-Intensity Interval Training: Which Promotes Higher Pleasure?

Bruno R. R. Oliveira, Fabian A. Slama, Andréa C. Deslandes, Elen S. Furtado, Tony M. Santos

A Novel Approach for Prediction of Vitamin D Status Using Support Vector Regression

Shuyu Guo, Robyn M. Lucas, Anne-Louise Ponsonby, the Ausimmune Investigator Group

Spatial Genetic Heterogeneity in Populations of a Newly Invasive Whitefly in China Revealed by a Nation-Wide Field Survey

Dong Chu, Hui-Peng Pan, Xian-Chun Li, Dong Guo, Yun-Li Tao, Bai-Ming Liu, You-Jun Zhang

De Novo Design and Synthesis of Ultra-Short Peptidomimetic Antibiotics Having Dual Antimicrobial and Anti-Inflammatory Activities

Ravichandran N. Murugan, Binu Jacob, Mija Ahn, Eunha Hwang, Hoik Sohn, Hyo-Nam Park, Eunjung Lee, Ji-Hyung Seo, Chaejoon Cheong, Ky-Youb Nam, Jae-Kyung Hyun, Ki-Woong Jeong, Yangmee Kim, Song Yub Shin, Jeong Kyu Bang

miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes

Pei-Shi Hung, Chung-Ji Liu, Chung-Shan Chou, Shou-Yen Kao, Cheng-Chieh Yang, Kuo-Wei Chang, Ting-Hui Chiu, Shu-Chun Lin

Spatial Hyperschematia without Spatial Neglect after Insulo-Thalamic Disconnection

Arnaud Saj, Juliane C. Wilcke, Markus Gschwind, Hélo？se Emond, Frédéric Assal

Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B

Francesca Iannilli, Francesca Zalfa, Annette Gartner, Claudia Bagni, Carlos G. Dotti

Characterization of a Chitin-Binding Protein from Bacillus thuringiensis HD-1

Naresh Arora, Bindiya Sachdev, Rani Gupta, Y. Vimala, Raj K. Bhatnagar

Intragenomic Profiling Using Multicopy Genes: The rDNA Internal Transcribed Spacer Sequences of the Freshwater Sponge Ephydatia fluviatilis

Liisi Karlep, T？nu Reintamm, Merike Kelve

Homology Modeling of the CheW Coupling Protein of the Chemotaxis Signaling Complex

Derek J. Cashman, Davi R. Ortega, Igor B. Zhulin, Jerome Baudry

First Report of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) Infections in Invasive Rodents from Five Islands of the Ogasawara Archipelago, Japan

Toshihiro Tokiwa, Takuma Hashimoto, Tatsuo Yabe, Noriyuki Komatsu, Nobuaki Akao, Nobuo Ohta

Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery

Reedik M？gi, Sean Manning, Ahmed Yousseif, Andrea Pucci, Ferruccio Santini, Efthimia Karra, Giorgia Querci, Caterina Pelosini, Mark I. McCarthy, Cecilia M. Lindgren, Rachel L. Batterham

Molecular and Clinical Characteristics of Clonal Complex 59 Methicillin-Resistant Staphylococcus aureus Infections in Mainland China

Juan Li, Lijuan Wang, Margaret Ip, Mingjiao Sun, Jing Sun, Guoying Huang, Chuanqing Wang, Li Deng, Yuejie Zheng, Zhou Fu, Changcong Li, Yunxiao Shang, Changan Zhao, Sangjie Yu, Kaihu Yao, Yonghong Yang, Xuzhuang Shen

The In Vitro Mass-Produced Model Mycorrhizal Fungus, Rhizophagus irregularis, Significantly Increases Yields of the Globally Important Food Security Crop Cassava

Isabel Ceballos, Michael Ruiz, Cristhian Fernández, Ricardo Pe？a, Alia Rodríguez, Ian R. Sanders

Varietal Tracing of Virgin Olive Oils Based on Plastid DNA Variation Profiling

Marga Pérez-Jiménez, Guillaume Besnard, Gabriel Dorado, Pilar Hernandez

miR-105 Inhibits Prostate Tumour Growth by Suppressing CDK6 Levels

D. Rice Honeywell, Miguel A. Cabrita, Huijun Zhao, Jim Dimitroulakos, Christina L. Addison

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