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PLOS ONE

ISSN Print: 1932-6203

ISSN Online:

主页: http://www.plosone.org/

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Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Olga V. Matveeva,Yibin Kang,Alexey N. Spiridonov,P？l S？trom,Vladimir A. Nemtsov,Aleksey Y. Ogurtsov,Yury D. Nechipurenko,Svetlana A. Shabalina

Oxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids

Piotr Ruchala,Mohamad Navab,Chun-Ling Jung,Susan Hama-Levy,Ewa D. Micewicz,Hai Luong,Jonathan E. Reyles,Shantanu Sharma,Alan J. Waring,Alan M. Fogelman,Robert I. Lehrer

Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis

Irini Tossidou,Beina Teng,Jan Menne,Nelli Shushakova,Joon-Keun Park,Jan U. Becker,Friedrich Modde,Michael Leitges,Hermann Haller,Mario Schiffer

Specific Recognition of Influenza A/H1N1/2009 Antibodies in Human Serum: A Simple Virus-Free ELISA Method

Mario M. Alvarez,Felipe López-Pacheco,José M. Aguilar-Ya？ez,Roberto Portillo-Lara,Gonzalo I. Mendoza-Ochoa,Sergio García-Echauri,Pamela Freiden,Stacey Schultz-Cherry,Manuel I. Zertuche-Guerra,David Bulnes-Abundis,Johari Salgado-Gallegos,Leticia Elizondo-Montemayor,Martín Hernández-Torre

Fitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype

Andrea von Groll,Anandi Martin,Matthias Stehr,Mahavir Singh,Fran？oise Portaels,Pedro Eduardo Almeida da Silva,Juan Carlos Palomino

Myostatin Is Upregulated Following Stress in an Erk-Dependent Manner and Negatively Regulates Cardiomyocyte Growth in Culture and in a Mouse Model

Lawrence T. Bish,Kevin J. Morine,Meg M. Sleeper,H. Lee Sweeney

β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling

Meghan T. Maher,Rigen Mo,Annette S. Flozak,Ofra N. Peled,Cara J. Gottardi

Microevolution of Group A Streptococci In Vivo: Capturing Regulatory Networks Engaged in Sociomicrobiology, Niche Adaptation, and Hypervirulence

Ramy K. Aziz,Rita Kansal,Bruce J. Aronow,William L. Taylor,Sarah L. Rowe,Michael Kubal,Gursharan S. Chhatwal,Mark J. Walker,Malak Kotb

Gcg-XTEN: An Improved Glucagon Capable of Preventing Hypoglycemia without Increasing Baseline Blood Glucose

Nathan C. Geething,Wayne To,Benjamin J. Spink,Michael D. Scholle,Chia-wei Wang,Yong Yin,Yi Yao,Volker Schellenberger,Jeffrey L. Cleland,Willem P. C. Stemmer,Joshua Silverman

A Defined and Xeno-Free Culture Method Enabling the Establishment of Clinical-Grade Human Embryonic, Induced Pluripotent and Adipose Stem Cells

Kristiina Rajala,Bettina Lindroos,Samer M. Hussein,Riikka S. Lappalainen,Mari Pekkanen-Mattila,Jose Inzunza,Bj？rn Rozell,Susanna Miettinen,Susanna Narkilahti,Erja Kerkel？,Katriina Aalto-Set？l？,Timo Otonkoski,Riitta Suuronen,Outi Hovatta,Heli Skottman

Common Garden Experiment Reveals Genetic Control of Phenotypic Divergence between Swamp Sparrow Subspecies That Lack Divergence in Neutral Genotypes

Barbara Ballentine,Russell Greenberg

Homeodomain Interacting Protein Kinase 2: A Target for Alzheimer's Beta Amyloid Leading to Misfolded p53 and Inappropriate Cell Survival

Cristina Lanni,Lavinia Nardinocchi,Rosa Puca,Serena Stanga,Daniela Uberti,Maurizio Memo,Stefano Govoni,Gabriella D'Orazi,Marco Racchi

Role of CD14 in a Mouse Model of Acute Lung Inflammation Induced by Different Lipopolysaccharide Chemotypes

Adam A. Anas,Joppe W. R. Hovius,Cornelis van 't Veer,Tom van der Poll,Alex F. de Vos

Molecular Basis of eRF3 Recognition by the MLLE Domain of Poly(A)-Binding Protein

Guennadi Kozlov,Kalle Gehring

Functional Evaluation of Plasmodium Export Signals in Plasmodium berghei Suggests Multiple Modes of Protein Export

Puran Singh Sijwali,Philip J. Rosenthal

Improved Microarray-Based Decision Support with Graph Encoded Interactome Data

Anneleen Daemen,Marco Signoretto,Olivier Gevaert,Johan A. K. Suykens,Bart De Moor

Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

Jing Xu,Jun-Ying Zhou,Wei-Zen Wei,Gen Sheng Wu

Why Do African Elephants (Loxodonta africana) Simulate Oestrus? An Analysis of Longitudinal Data

Lucy A. Bates,Rosie Handford,Phyllis C. Lee,Norah Njiraini,Joyce H. Poole,Katito Sayialel,Soila Sayialel,Cynthia J. Moss,Richard W. Byrne

Actuating Mechanism and Design of a Cylindrical Traveling Wave Ultrasonic Motor Using Cantilever Type Composite Transducer

Yingxiang Liu,Weishan Chen,Junkao Liu,Shengjun Shi

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

Angela C. Poole,Ruth E. Thomas,Selina Yu,Evelyn S. Vincow,Leo Pallanck

FAM5C Contributes to Aggressive Periodontitis

Flavia M. Carvalho,Eduardo M. B. Tinoco,Kathleen Deeley,Poliana M. Duarte,Marcelo Faveri,Marcelo R. Marques,Adriana C. Mendon？a,Xiaojing Wang,Karen Cuenco,Renato Menezes,Gustavo P. Garlet,Alexandre R. Vieira

The HSP70 Molecular Chaperone Is Not Beneficial in a Mouse Model of α-synucleinopathy

Derya R. Shimshek,Matthias Mueller,Christoph Wiessner,Tatjana Schweizer,P. Herman van der Putten

Phenotypic Covariance of Longevity, Immunity and Stress Resistance in the Caenorhabditis Nematodes

Francis R. G. Amrit,Claudia M. L. Boehnisch,Robin C. May

ESNOQ, Proteomic Quantification of Endogenous S-Nitrosation

Xixi Zhou,Peiwei Han,Jiangmei Li,Xu Zhang,Bo Huang,Hong-Qiang Ruan,Chang Chen

Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E

Fotios Drenos,Thomas B. L. Kirkwood

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Patricia Spilman,Natalia Podlutskaya,Matthew J. Hart,Jayanta Debnath,Olivia Gorostiza,Dale Bredesen,Arlan Richardson,Randy Strong,Veronica Galvan

Paternal Genetic Contribution Influences Fetal Vulnerability to Maternal Alcohol Consumption in a Rat Model of Fetal Alcohol Spectrum Disorder

Laura J. Sittig,Eva E. Redei

“Positive” Results Increase Down the Hierarchy of the Sciences

Daniele Fanelli

Quantifying Recent Ecological Changes in Remote Lakes of North America and Greenland Using Sediment Diatom Assemblages

William O. Hobbs,Richard J. Telford,H. John B. Birks,Jasmine E. Saros,Roderick R. O. Hazewinkel,Bianca B. Perren,émilie Saulnier-Talbot,Alexander P. Wolfe

Ganglioside GM3 Levels Are Altered in a Mouse Model of HIBM: GM3 as a Cellular Marker of the Disease

Thomas Paccalet,Zoé Coulombe,Jacques P. Tremblay

Evaluating Molecular Mechanical Potentials for Helical Peptides and Proteins

Erik J. Thompson,Allison J. DePaul,Sarav S. Patel,Eric J. Sorin

ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes

Andrew K. Marshall,Oliver P. T. Barrett,Timothy E. Cullingford,Achchuthan Shanmugasundram,Peter H. Sugden,Angela Clerk

Angiotensin II Inhibits Insulin-Stimulated GLUT4 Translocation and Akt Activation through Tyrosine Nitration-Dependent Mechanisms

Alfredo Csibi,David Communi,Nathalie Müller,Serge P. Bottari

CXCR4 Mediated Chemotaxis Is Regulated by 5T4 Oncofetal Glycoprotein in Mouse Embryonic Cells

Thomas D. Southgate,Owen J. McGinn,Fernanda V. Castro,Andrzej J. Rutkowski,Mariam Al-Muftah,Georgi Marinov,Graeme J. Smethurst,David Shaw,Christopher M. Ward,Crispin J. Miller,Peter L. Stern

A Common Carcinogen Benzo[a]pyrene Causes Neuronal Death in Mouse via Microglial Activation

Kallol Dutta,Debapriya Ghosh,Arshed Nazmi,Kanhaiya Lal Kumawat,Anirban Basu

Depression, Anxiety and Glucose Metabolism in the General Dutch Population: The New Hoorn Study

Vanessa Bouwman,Marcel C. Adriaanse,Esther van ’t Riet,Frank J. Snoek,Jacqueline M. Dekker,Giel Nijpels

The Walking Behaviour of Pedestrian Social Groups and Its Impact on Crowd Dynamics

Mehdi Moussa？d,Niriaska Perozo,Simon Garnier,Dirk Helbing,Guy Theraulaz

Dissection of Host Cell Signal Transduction during Acinetobacter baumannii – Triggered Inflammatory Response

Catalina March,Verónica Regueiro,Enrique Llobet,David Moranta,Pau Morey,Junkal Garmendia,José A. Bengoechea

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

Najwane Sa？d-Sadier,Eduardo Padilla,Gordon Langsley,David M. Ojcius

ARNTL (BMAL1) and NPAS2 Gene Variants Contribute to Fertility and Seasonality

Leena Kovanen,Sirkku T. Saarikoski,Arpo Aromaa,Jouko L？nnqvist,Timo Partonen

Enhanced Beetle Luciferase for High-Resolution Bioluminescence Imaging

Yoshihiro Nakajima,Tomomi Yamazaki,Shigeaki Nishii,Takako Noguchi,Hideto Hoshino,Kazuki Niwa,Vadim R. Viviani,Yoshihiro Ohmiya

Binding Site Alteration Is Responsible for Field-Isolated Resistance to Bacillus thuringiensis Cry2A Insecticidal Proteins in Two Helicoverpa Species

Silvia Caccia,Carmen Sara Hernández-Rodríguez,Rod J. Mahon,Sharon Downes,William James,Nadine Bautsoens,Jeroen Van Rie,Juan Ferré

The Population Structure of Acinetobacter baumannii: Expanding Multiresistant Clones from an Ancestral Susceptible Genetic Pool

Laure Diancourt,Virginie Passet,Alexandr Nemec,Lenie Dijkshoorn,Sylvain Brisse

A Study of the Influence of Sex on Genome Wide Methylation

Jingyu Liu,Marilee Morgan,Kent Hutchison,Vince D. Calhoun

Vesicomyidae (Bivalvia): Current Taxonomy and Distribution

Elena M. Krylova,Heiko Sahling

TiArA: A Virtual Appliance for the Analysis of Tiling Array Data

Jason A. Greenbaum,Erika Assarsson,Jo L. Chung,Steven Head,Alessandro Sette,Bjoern Peters

The Relationship of Omental and Subcutaneous Adipocyte Size to Metabolic Disease in Severe Obesity

Jean O'Connell,Lydia Lynch,Tom J. Cawood,Anna Kwasnik,Niamh Nolan,Justin Geoghegan,Aiden McCormick,Cliona O'Farrelly,Donal O'Shea

Granuloma Encapsulation Is a Key Factor for Containing Tuberculosis Infection in Minipigs

Olga Gil,Ivan Díaz,Cristina Vilaplana,Gustavo Tapia,Jorge Díaz,María Fort,Neus Cáceres,Sergio Pinto,Joan Caylà,Leigh Corner,Mariano Domingo,Pere-Joan Cardona

eIF5A Promotes Translation Elongation, Polysome Disassembly and Stress Granule Assembly

Chi Ho Li,Takbum Ohn,Pavel Ivanov,Sarah Tisdale,Paul Anderson

Association and Linkage Analysis of Aluminum Tolerance Genes in Maize

Allison M. Krill,Matias Kirst,Leon V. Kochian,Edward S. Buckler,Owen A. Hoekenga

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