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ISSN: 2333-9721
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主页: https://pubs.acs.org/journal/amclct

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Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

SAR Studies of N-[2-(1H-Tetrazol-5-yl)phenyl]benzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists

Synthesis of Phosphatidylserine and Its Stereoisomers: Their Role in Activation of Blood Coagulation

Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1

Using tert-Butyl Groups in a Ligand To Identify Its Binding Site on a Protein

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

Click-Addressable Cassette for Photoaffinity Labeling

Efficient Syntheses of Cocaine Vaccines and Their in Vivo Evaluation

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

H2O2/Peroxynitrite-Activated Hydroxamic Acid HDAC Inhibitor Prodrugs Show Antileukemic Activities against AML Cells

Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase

Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice

Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics

Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8

Investigating the Behavior of Published PAINS Alerts Using a Pharmaceutical Company Data Set

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease

Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies

Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry

Daedal Facets of Splice Modulator Optimization

New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif

Transforming Computational Drug Discovery with Machine Learning and AI

Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins

Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor

New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery

Cystine-based MBioF for Maintaining the Antioxidant–Oxidant Balance in Airway Diseases

Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection

Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1′ Extension

2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4

Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors

In Search of the Optimal Macrocyclization Site for Neurotensin

Academic Drug Development: The DRIVE Model

Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue

Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays

What Do You Get from DNA-Encoded Libraries?

Riluzole–Triazole Hybrids as Novel Chemical Probes for Neuroprotection in Amyotrophic Lateral Sclerosis

Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs

Azithromycin-Induced Changes to Bacterial Membrane Properties Monitored in Vitro by Second-Harmonic Light Scattering

Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor

Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules

SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase

Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)

VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events

Ribosome-Templated Azide–Alkyne Cycloadditions Using Resistant Bacteria as Reaction Vessels: in Cellulo Click Chemistry

Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor

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