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ISSN: 2333-9721
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Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

Carlos Ardavín,Ekta Lachmandas,Frank L. van de Veerdonk,Jacqueline M. Ratter,Jorge Domínguez-Andrés,Leo A. B. Joosten,Lily Boutens,Mark S. Gresnigt,Mihai G. Netea,Richard A. Notebaart,Rob J. W. Arts,Rob ter Horst,Sanne P. Smeekens

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA

Aline C. Habison,Bruno Correia,Chantal Beauchemin,Colin E. McVey,Edward J. Usherwood,J. Pedro Simas,Kenneth M. Kaye,Marta Pires de Miranda,Min Tan,Rajesh Ponnusamy,Sofia A. Cerqueira

Different rates of spontaneous mutation of chloroplastic and nuclear viroids as determined by high-fidelity ultra-deep sequencing

Amparo López-Carrasco,Cristina Ballesteros,Rafael Sanjuán,Ricardo Flores,Selma Gago-Zachert,Sonia Delgado,Vicente Sentandreu

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

Bo Zhong,Heng Lin,Hong-Bing Shu,Jin Wei,Man Zhang,Ming-Ming Hu,Qing Yang,Tian-Tian Liu,Wei-Wei Luo,Yun-Hong Hu

HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis

Akil Hammami,Annie-Pier Duguay,Aymeric Fabié,Belma Melda Abidin,Krista M. Heinonen,Simona St？ger,Tania Charpentier

Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization

Alberto Marina,Christian Alite,Elisa Maiques,Iltyar Mehmedov,J. Rafael Ciges-Tomas,Janine Bowring,Jorge Donderis,José R. Penadés,María Angeles Tormo-Mas

Divergent LysM effectors contribute to the virulence of Beauveria bassiana by evasion of insect immune defenses

Bing Li,Chengshu Wang,Kai Cen,Siwei Zhang,Yuzhen Lu

Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling

David S. J. Allan,James R. Carlyle,Lauren A. Zenewicz,Sudarshan Seshadri

MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

Alan Wells,Bhushan B Kode,Donna Stolz,George Michalopoulos,Jakob Z. Wells,Jennie Vorhauer,Melanie Scott,Mounia Alaoui-EL-Azher,Muhamuda Kader,Nahed Ismail

A conserved fungal glycosyltransferase facilitates pathogenesis of plants by enabling hyphal growth on solid surfaces

Alison Lovegrove,Amy Plummer,Jason J. Rudd,Kim Hammond-Kosack,Kirstie Halsey,Martin Urban,Matthew Evans,Nichola Hawkins,Rebecca P. Lauder,Robert King

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection

Amandine Martin,Amandine Mosnier,Anders Sj？stedt,Angelina Provost,Brice Lagrange,Bénédicte F. Py,Eric Faudry,Etienne Meunier,Fanny Michal,Helena Lindgren,Igor Golovliov,Masahiro Yamamoto,Omran Allatif,Pauline Basso,Petr Broz,Pierre Wallet,Sacha Benaoudia,Sophia Djebali,Thomas Henry

Experience-dependent olfactory behaviors of the parasitic nematode Heligmosomoides polygyrus

Elissa A. Hallem,Felicitas Ruiz,Michelle L. Castelletto,Spencer S. Gang

H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation

E. Stein Esser,Elena V. Vassilieva,Elizabeth Q. Littauer,Ioanna Skountzou,Olivia Q. Antao,Richard W. Compans

The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria

Alyson C. Yoder,Cara C. Wilson,Christina Ochsenbauer,Eric J. Lee,John C. Kappes,Karen Helm,Kejun Guo,Mario L. Santiago,Martin D. McCarter,Michael S. Harper,Stephanie M. Dillon,Tzu Phang

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

Anne-Sophie Dangeard,Christoph Alexander Kasper,Claudine Pique,Cécile Arrieumerlou,Julie Guignot,Mario Emmenlauer,Milica Milivojevic,Pamela Schnupf,Therese Tschon

Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells

Margo A. Brinton,Mausumi Basu,Sean C. Courtney

Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems

Aurélie Deveau,Jessie Uehling,Mathieu Paoletti

miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

Amit Kapoor,Bud C. Tennant,Charles M. Rice,Douglas F. Antczak,Eiko Nishiuchi,Hachung Chung,Ian W. Lipkin,Inna Ricardo-Lax,Joseph M. Luna,Margaret A. Scull,Natalia Echeverría,Thomas J. Divers,Troels K. H. Scheel,Yingpu Yu

Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways

Ajit Lalvani,Alice Halliday,Ann-Kathrin Reuschl,Corrina Wright,David W. Connell,Hannah Jarvis,Long Hoang,Michael R. Edwards,Nazneen Siddiqui,Onn Min Kon,Peter Beverley,Robert Parker,Robin J. Shattock,Samuel Bremang,Sandra M. Newton

The immune battlefield: The impact of inflammatory cytokines on CD8+ T-cell immunity

Martin J. Richer,Stephanie A. Condotta

Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice

Chao Zhang,Chaonan Shi,Chunhong Wei,Feng Sun,Hong Wang,Jianguo Wu,Lianhui Xie,Lijia Zheng,Qingqing Qin,Rui Qiao,Shanshan Zhao,Tong Zhou,Yi Li,Yu Wang,Zhirui Yang,Zuomei Ding

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways

Caroline Wright,David J. Rowlands,Joseph C. Ward,Lidia Lasecka-Dykes,Morgan R. Herod,Nicola J. Stonehouse,Sarah Gold,Sophie Forrest,Terry Jackson,Thomas C. McLean,Tobias J. Tuthill

Single-cell analysis identifies cellular markers of the HIV permissive cell

Amalio Telenti,Angela Ciuffi,Antonio Rausell,Miguel Mu？oz,Sylvie Rato

Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication

Bei Wang,Bin Pei,Chaofei Cheng,Chongyang Zhang,He Huang,Jianwei Wang,Lei Sun,Qi Jin,Tao Wang,Yuanmei Zhu,Zhendong Zhao

Role of Arf GTPases in fungal morphogenesis and virulence

Hayet Labbaoui,Martine Bassilana,Norma V. Solis,Robert A. Arkowitz,Scott G. Filler,Stéphanie Bogliolo,Vikram Ghugtyal

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Adam Taylor,Andreas Suhrbier,Bing Tang,Francesca Di Giallonardo,Helen E. Cumming,Jane A. C. Wilson,Jonathan J. Ellis,Joy Gardner,Linda Hueston,Linden J. Gearing,Natalie A. Prow,Paul J. Hertzog,Phillip I. Bird,Pierre Roques,Roger Le Grand,Suresh Mahalingam,Thuy T. Le,Wayne A. Schroder,Yee Suan Poo

Interaction between the flagellar pocket collar and the hook complex via a novel microtubule-binding protein in Trypanosoma brucei

Anna Albisetti,Célia Florimond,Derrick Roy Robinson,Gang Dong,Johannes Lesigang,Keni Vidilaseris,Marie Eggenspieler,Mélanie Bonhivers,Nicolas Landrein

Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid

Andrew M. Burrage,Benoit Roger,Carola Schneider,Charlotte Montespan,Christopher M. Wiethoff,Edward M. Campell,Fabienne Rayne,Harald Wodrich,Kay Grünewald,Muriel Faure,Rudolph Reimer,Shauna A. Marvin,Sisley Austin

Bacteria and bacterial envelope components enhance mammalian reovirus thermostability

Angela K. Berger,Bernardo A. Mainou,Daniel B. Kearns,Hong Yi

Species-specific functions of Epstein-Barr virus nuclear antigen 2 (EBNA2) reveal dual roles for initiation and maintenance of B cell immortalization

Fred Wang,Janine Mühe

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells

Ana Fernandez-Sesma,Ana M. Maestre,Andrea V. Gamarnik,Carol D. Blair,Cintia Fabri,Claudia V. Filomatori,Horacio M. Pallarés,Irma Sánchez-Vargas,Juan M. Carballeda,Maria A. Morales,Sebastian Aguirre,Sergio M. Villordo

Secretory proteins are delivered to the septin-organized penetration interface during root infection by Verticillium dahliae

Hui-Shan Guo,Ting-Ting Zhou,Yun-Long Zhao

Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels

Adriana Báez,Beatriz Alvarez,Cecilia Fernández,Emilio Salceda,Enrique Soto,Leonardo Pellizza,Mariana Margenat,Martín Fló,Martín Gra？a,Rosario Durán

Tissue-specific control of latent CMV reactivation by regulatory T cells

Allyson Sholl,Claire Chougnet,David A. Hildeman,Jana Raynor,Maha Almanan,Mei Wang,Rhonda D. Cardin

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

Camilo Duque Velásquez,Debbie McKenzie,Glenn Telling,Holger Wille,Lyudmyla Dorosh,Maria Stepanova,Sabine Gilch,Samia Hannaoui,Sampson Law,Sara Amidian,Yo Ching Cheng

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission

Andreas Rummel,Elisa Duregotti,Giulia Zanetti,Marco Pirazzini,Nadja Krez,Ornella Rossetto,Samuele Negro,Stefan Sikorra,Thomas Binz,Tina Henke

Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques

Blake Frey,Christopher J. Miller,Jay A. Berzofsky,Katherine McKinnon,Linda Fritts,Rolf Billeskov,Shweta Kulkarni,Tracy Rourke,Yichuan Wang,Yongjun Sui

Structural insights into reptarenavirus cap-snatching machinery

Bianka Rauschenberger,Dominik Vogel,Juan Reguera,Maria Rosenthal,Nadja Gogrefe,Sophia Reindl,Stephan Günther,Stephen Cusack

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium

Bernhard Holzmann,Christin Friedrich,Friederike Kruse,Matthias Lochner,Panagiota Mamareli,Sophie Thiemann,Till Strowig,Tim Sparwasser,Zuobai Wang

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

Alessandro Cascioferro,Andrew R. Bottrill,Barbara Rieck,Fabien le Chevalier,Francesca Boldrin,Giulia Degiacomi,Helen M. O’Hare,Liem Nguyen,Marco Bellinzoni,María-Natalia Lisa,Michael Zimmermann,Natalie R. Lazar-Adler,Pedro M. Alzari,Riccardo Manganelli,Roland Brosch,Uwe Sauer,Wafa Frigui

The plasmid-encoded Ipf and Klf fimbriae display different expression and varying roles in the virulence of Salmonella enterica serovar Infantis in mouse vs. avian hosts

Galia Rahav,Gili Aviv,Guntram A. Grassl,Helit Cohen,Laura Elpers,Michael Hensel,Ohad Gal-Mor,Shaul Vitman Zilber,Svetlana Mikhlin

Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D

An Li,George F. Gao,Guangwen Lu,Jianxun Qi,Jinghua Yan,Kegong Tian,Lili Wu,Tingrong Luo,Yi Shi

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants

Baldeep Khare,Ben A. Bailey-Elkin,Brian L. Mark,Garrett G. Johnson,Jun Gu,Marjolein Kikkert,Nigel J. McLeish,Puck B. van Kasteren,Robert C. M. Knaap,Sachdev S. Sidhu,Tim J. Dalebout,Wei Zhang,Wenguang He

The AraC Negative Regulator family modulates the activity of histone-like proteins in pathogenic bacteria

Araceli E. Santiago,Brooke Sauder,David A. Rasko,Fernando Ruiz-Perez,James P. Nataro,Mario Meza-Segura,Melissa M. Kendall,Michael B. Yan,Tracy H. Hazen

Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase

Damien Calay,Justin C. Mason,Marina Botto,Mark Reglinski,Matthew K. Siggins,Nicola N. Lynskey,Shiranee Sriskandan

Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets

Albert D. M. E. Osterhaus,Alwin de Jong,Debby van Riel,Geert van Amerongen,Linda J. Rennick,Martin Ludlow,Peter R. W. A. van Run,R. Joyce Verburgh,Rik L. de Swart,Ron A. M. Fouchier,Rory D. de Vries,Sander Herfst,Thijs Kuiken,W. Paul Duprex

Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa

David J. Evans,Jianfang Li,Matteo M. E. Metruccio,Suzanne M. J. Fleiszig

The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV

Andrew Leis,Geoff J. Dumsday,Hanumant S. Tanwar,Johnson Mak,Keith K. Khoo,Lynne Waddington,Marcel Hijnen,Megan Garvey,Tony Velkov,William J. McKinstry

A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species

Diana N. Medina-Perez,Jenny A. Hyde,Jon T. Skare,Lihui Gao,Linden T. Hu,Maureen E. Lundt,Meghan E. Ramsey,Steven J. Norris,Tao Lin,Xin Li

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer

Alexandra Adamczyk,Annika Frede,Astrid M. Westendorf,Eva Pastille,Henry J. McSorley,Jan Buer,Jessica Gr？b,Matthias Epple,Rick M. Maizels,Robert Klopfleisch,Sebastian Kollenda,Wiebke Hansen

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