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ISSN: 2333-9721
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Full-length human cytomegalovirus terminase pUL89 adopts a two-domain structure specific for DNA packaging

Andreas Holzenburg,Elke Bogner,Janine Thei？,Min Woo Sung

Dissemination of Chlamydia from the reproductive tract to the gastro-intestinal tract occurs in stages and relies on Chlamydia transport by host cells

Nita Shillova,Savannah E. Howe,Vjollca Konjufca

Correction: The bZIP Transcription Factor MoAP1 Mediates the Oxidative Stress Response and is Critical for Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae

Haifeng Zhang,Min Guo,Ping Wang,Su Zhai,Suomeng Dong,Wang Guo,Xiaobo Zheng,Yan Du,Yanhan Dong,Yuanchao Wang,Yue Chen,Zhengguang Zhang

Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production

Adriana Le Van,Aleksandra E. Sikora,Ann E. Jerse,Benjamin I. Baarda,Ryszard A. Zielke

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells

Christian Taube,Daniel Teschner,Frederic Ries,Hendrik Beckert,Joachim Maxeiner,Jürgen Podlech,Kirsten Freitag,Matthias J. Reddehase,Niels A. W. Lemmermann,Rafaela Holtappels,Roland Buhl,Sebastian Reuter

Human apolipoprotein E promotes hepatitis B virus infection and production

Guangxiang George Luo,Luhua Qiao

Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization

Alyson R. Warr,Brigid M. Davis,Carlos J. Blondel,Diana Munera,Matthew K. Waldor,Pia Abel zur Wiesch,S？ren Abel,Troy P. Hubbard,Xiaoxue Wang

Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics

Richard K. Plemper,Venice Du Pont,Yi Jiang

Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations

Adrian Curran,Ariadna Torrella,Bibiana Planas,Esteban Ribera,Jesús Fernández-Sojo,Joaquin Burgos,Jordi Navarro,Judith Grau-Expósito,Laura Luque-Ballesteros,Maria J. Buzon,Mario Martin-Castillo,Meritxell Genescà,Rosa Badía,Vicen？ Falcó

Cyclic-di-GMP binds to histidine kinase RavS to control RavS-RavR phosphotransfer and regulates the bacterial lifestyle transition between virulence and swimming

Fang-Fang Wang,Shou-Ting Cheng,Wei Qian

Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis

Camila Oliveira Silva Souza,Dario Sim？es Zamboni,Jo？o Santana Silva,Lucas Alves Tavares,Luciana Benevides,Luiz Gustavo Gardinassi,Maria Cláudia Silva,Natália Ketelut-Carneiro

Plasma membrane damage repair is mediated by an acid sphingomyelinase in Entamoeba histolytica

B. Liliana Espa？a-Sánchez,Bernardo Franco,Claudia Mendoza-Macías,Felipe Padilla-Vaca,Fernando Anaya-Velázquez,Fátima Ramírez-Montiel,Gabriel Luna-Bárcenas,Itzel Páramo-Pérez,Paris E. Rivera-Cuéllar,Sairy Andrade-Guillén,ángeles Rangel-Serrano

Exposure to opposing temperature extremes causes comparable effects on Cardinium density but contrasting effects on Cardinium-induced cytoplasmic incompatibility

Martha S. Hunter,Matthew R. Doremus,Suzanne E. Kelly

The small non-coding RNA RsaE influences extracellular matrix composition in Staphylococcus epidermidis biofilm communities

Claudia Lange,Cynthia M. Sharma,Freya D. R. Wencker,Gabriella Marincola,Konrad U. F？rstner,Maike F. Lerch,Sonja M. K. Schoenfelder,Srinivasa Abishek Prakash,Wilma Ziebuhr

Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signalling and drug detoxification and are essential for parasite survival

Alex Loukas,Bemnet A. Tedla,Darren Pickering,Javier Sotillo,Luke Becker,Mark S. Pearson,Ramon M. Eichenberger,Stephanie Ryan

Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model

Alan N. Engelman,Anna Kilbey,Christine A. Kozak,Dylan Fingerman,Ewan Cameron,Gillian Borland,James Neil,Jodie Hay,Kathryn Gilroy,Lorenz Loyola,Margaret Bell,Monica J. Roth,Nancy Mackay,Rodrigo A. Villanueva,Sriram Aiyer,Vasudevan Achuthan

RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals

Aki Imai-Matsushima,Alexander Karlas,Andreas Herrmann,Christian Sieben,Friderike Weege,Günther Sch？nrich,Isabella Gravenstein,Laura Martin-Sancho,Madlen Luckner,Markus Lesch,Martin Raftery,Michael Meyer,Rebecca Frise,Robert-William Welke,Thomas F. Meyer,Wendy Barclay

Sympatric versus allopatric evolutionary contexts shape differential immune response in Biomphalaria / Schistosoma interaction

Ana？s Portet,Benjamin Gourbal,Cristian Chaparro,David Duval,Guillaume M. Charriere,Jean-Fran？ois Allienne,Julien Portela,Nolwenn M. Dheilly,Richard Galinier,Silvain Pinaud

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue

Andre van der Ven,Bachti Alisjahbana,Dirk J. Lefeber,Fadel M. Garishah,Gijs J. Overheul,Gloria S. R. Utari,M. Hussein Gasem,Nur Farhanah,Philip. G. de Groot,Quirijn de Mast,Rahajeng N. Tunjungputri,Rolf T. Urbanus,Ronald P. van Rij,Silvita Fitri Riswari,Vesla Kullaya

Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection

Amit Ranjan,Angela Thompson,Anna Dongari-Bagtzoglou,Kendra Maas,Martinna Bertolini,Patricia I. Diaz,Takanori Sobue

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Andy Wullaert,Frederic Sorgeloos,Geert van Loo,Hanne Dubois,Ian Goodfellow,Jason M. Mackenzie,Liesbet Martens,Mohamed Lamkanfi,Soroush T. Sarvestani,Yvan Saeys

Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms

Daniel C. Stein,Liang-Chun Wang,Qian Yu,Scott D. Gray-Owen,Sofia Di Benigno,Wenxia Song

Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function

Andrew N. Bubak,Anna Blackmon,Brent E. Palmer,Charles Preston Neff,Christina N. Como,Dallas Jones,David M. Koelle,Lichen Jing,Maria A. Nagel,Owen Krueger

A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans

Adnane Sellam,Ana？s Burgain,Carol A. Kumamoto,Faiza Tebbji,Laura Markey,émilie Pic

Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection

Aimee L. Brauer,Alexandra O. Johnson,Ashley N. White,Brian S. Learman,Chelsie E. Armbruster,Harry L. T. Mobley,Lili Zhao,Mark T. Anderson,Michael A. Bachman,Sara N. Smith,Valerie S. Forsyth,Weisheng Wu

p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress

Ayrianna Sparks-Wallace,Camri A. Nicksic,Carissa Kohne,Caroline Hawkins,Jonathan P. Moorman,Kenton H. Hall,Ling Wang,Mary E. A. Howell,Shunbin Ning,Zhi Q. Yao

KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication

Benjamin P. Johnston,Craig McCormick,Eric S. Pringle

The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein

Allison E. Roder,Christine Vazquez,Stacy M. Horner

Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits

Anna Gasiorek,Anna Makarska,Barbara Potempa,Danuta Bryzek,Ewelina Dobosz,Izabela Ciaston,Jan Potempa,Joanna Koziel,Maciej Lech,Magdalena Puklo,Michal Sarna,Sigrun Eick

Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection

Anne Hosmalin,Anne Oudin,Assia Samri,Brigitte Autran,Charlotte Charpentier,Christophe Parizot,Fideline Collin,Fran？oise Brun-Vézinet,Gilles Collin,Mariama Sadjo Diallo,Mélanie Bertine,Rima Zoorob,Rodolphe Thiébaut,Rémi Cheynier,Sophie Even,Sophie Matheron,Véronique Morin,the ANRS CO5 IMMUNOVIR-2 Study Group

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

Chengqun Sun,Derek W. Trobaugh,Douglas S. Reed,Matthew D. Dunn,William B. Klimstra

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus

Alexandre H. Lopes,Benedito A. L. da Fonseca,Carlos H. Hiroki,Dario S. Zamboni,Fernando Q. Cunha,Fernando Silva Ramalho,Luiza A. de Castro-Jorge,Marcílio Jorge Fumagalli,Mayara R. Agostinho,Rafaela M. Guimar？es,Renan V. H. de Carvalho,Renata Dezengrini Slhessarenko,Taline M. Klein,Thiago M. Cunha,Vitor G. Floriano

A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii

Carmen Melatti,Ehmke Pohl,Leandro Lemgruber,Lilach Sheiner,Manuela Pieperhoff,Markus Meissner

Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc

Abu Mohammed Taufiqual Islam,Blaine Roberts,David Isaac Finkelstein,Laura Jane Ellett,Matteo Senesi,Paul Anthony Adlard,Simote Totauhelotu Foliaki,Steven John Collins,Victoria A. Lawson,Victoria Lewis

Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor

Ana Angulo,Antonio Alcamí,Carolina Sánchez,Domènec Farré,Pablo Engel,Pablo Martínez-Vicente

T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium

Carlito B. Lebrilla,Charles L. Bevins,Colin Reardon,Dayn R. Godinez,Diane Tu,Elaine N. Miller,Eric B. Nonnecke,Ingrid Brust-Mascher,Jessica A. Sladek,Mariana Barboza Gardner,Melanie G. Gareau,Patricia A. Castillo,Valerie T. Ramirez

A model of chronic, transmissible Otitis Media in mice

Amanda L. Skarlupka,Brian T. Faddis,Dawn L. Taylor-Mulneix,Eric T. Harvill,Kalyan K. Dewan,Laura L. Campos,Longhua Ma,Monica C. Gestal,Shannon M. Wagner,Uriel Blas-Machado,Valerie E. Ryman

Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance

Barbara M. Waring,Brian D. Brown,Brian T. Fife,Ian A. Stone,Jessica K. Fiege,Judith Agudo,Nicholas S. Heaton,Rebekah E. Dumm,Ryan A. Langlois

Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel

Alan P. Robertson,Daniel Kulke,Denis Voronin,Richard J. Martin,Sara Lustigman,Saurabh Verma,Sudhanva S. Kashyap

Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection

Anna Malyshkina,Ina Wensing,Kerstin Wohlgemuth,Meike Rückborn,Mirko Trilling,Nadine Bongard,Sonja Windmann,Ulf Dittmer,Vu Thuy Khanh Le-Trilling,Wibke Bayer

Pyruvate produced by Brugia spp. via glycolysis is essential for maintaining the mutualistic association between the parasite and its endosymbiont, Wolbachia

Alexandra Grote,Denis Voronin,Elodie Ghedin,Emily Schnall,Sara Lustigman,Shabnam Jawahar,Thomas R. Unnasch,Waleed Ali

Killing from the inside: Intracellular role of T3SS in the fate of Pseudomonas aeruginosa within macrophages revealed by mgtC and oprF mutants

Anne-Béatrice Blanc-Potard,Laurence Berry,Malika Moussouni,Preeti Garai,Sophie Bleves

The Orthotospovirus nonstructural protein NSs suppresses plant MYC-regulated jasmonate signaling leading to enhanced vector attraction and performance

Jian Ye,Pingzhi Zhao,Rongxiang Fang,Shuang Xu,Xiangmei Yao,Xiujuan Wu,Xuan Zhang,Yanwei Sun

Hidden regulation of herpes simplex virus 1 pre-mRNA splicing and polyadenylation by virally encoded immediate early gene ICP27

Amita Patel,Philip R. Krause,Shuang Tang

IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies

Chuan Qin,Fei Yu,Guangming Li,Jing Xue,Liang Cheng,Lishan Su,Lu Lu,Qi Wang,Qian Wang,Shibo Jiang,Shuai Xia,Wei Xu,Wenwen Bi

Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

Adriano G. Rossi,Brian J. McHugh,David Brough,Donald J. Davidson,Emily L. Gwyer Findlay,Holly Stevens,Hsin-Ni Li,Julia R. Dorin,Lisa Young,Paula E. Beaumont,Rebekah Kells,Robert D. Gray,Rongling Wang

Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes

Andrew J. Bett,Benjamin J. Doranz,Daniel R. DiStefano,Danilo R. Casimiro,Elizabeth A. Thoryk,Georgina T. Salazar,Jennifer M. Pfaff,Kalpit A. Vora,Leike Li,Melanie Horton,Ningyan Zhang,Qihui Wang,Trevor Barnes,Weixu Meng,Zhiqiang An

Histamine release from intestinal mast cells induced by staphylococcal enterotoxin A (SEA) evokes vomiting reflex in common marmoset

Akio Nakane,Dong-Liang Hu,Hisaya K. Ono,Kouji Narita,Krisana Asano,Makoto Sugiyama,Shouhei Hirose

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

Chun-Mei Li,Deyin Guo,Lanyi Zeng,Liu Cao,Qianyun Liu,Shuting Guo,Xiaolong Guo,Xiaolu Zhao,Yanxi Ji,Yongjia Tong,Yu Chen,Zhen Zhang

Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling

Fanhua Wei,George Fu Gao,Honglei Sun,Jinhua Liu,Juan Pu,Mingyang Wang,Qi Tong,Xiaojing Ma,Yipeng Sun,Yuhai Bi,Zhimin Jiang

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