The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer

Amy A. Irving,Dustin A. Deming,Erik Toraason,Jennifer K. Pleiman,Linda Clipson,Michael A. Newton,William F. Dove,Zhishi Wang

In search of the Goldilocks zone for hybrid speciation

Alexandre Blanckaert,Claudia Bank

Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans

Amanda C. Davis-Roca,Nikita S. Divekar,Rachel K. Ng,Sarah M. Wignall

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

Aurélie Cubizolle,Bertrand Mollereau,Claire Angebault-Prouteau,Daan M. Van Den Brink,Francesco Napoletano,Gilles Chatelain,Laurent Guillou,Michel Guichardant,Nathalie Bernoud-Hubac,Nathalie Davoust,Philippe Brabet,Pierre Dourlen,Simone Johansen,Victor Girard

Positive and negative regulation of transferred nif genes mediated by indigenous GlnR in Gram-positive Paenibacillus polymyxa

Haowei Zhang,Haowen Shi,Jilun Li,Li Sun,Qin Li,Sanfeng Chen,Tianshu Wang,Xiyun Zhao,Yongbin Li

Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans

Andres Ruiz-Linares,Carla Gallo,Changqing Zeng,Chen Chen,Fan Liu,Francisco Rothhammer,Fuduan Peng,Gabriel Bedoya,Giovanni Poletti,Hui Li,Jean Krutmann,Jingze Tan,Jinxi Li,Juan Zhang,Kaustubh Adhikari,Kun Tang,Lavinia Schuler-Faccini,Li Jin,Liang Zhang,Lina Wang,Manfei Zhang,Manfred Kayser,Maria-Cátira Bortolini,Merel A. Hamer,Qianqian Peng,Rolando González-José,Samuel Canizales-Quinteros,Shuhua Xu,Sijia Wang,Sijie Wu,Tamar Nijsten,Xinzhou Yang,Yajun Yang,Yanan Hu,Yaqun Guan,Yu Liu

Detecting archaic introgression using an unadmixed outgroup

Asger Hobolth,Aylwyn Scally,Laurits Skov,Mikkel Heide Schierup,Richard Durbin,Ruoyun Hui,Vladimir Shchur

Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations

Christopher C. Porter,Donovan J. Anderson,Marshall S. Horwitz,Matthew R. Hart,Michael Levin,Tobias Neff

Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

Anna Di Rienzo,Buddha Basnyat,Choongwon Jeong,Cynthia M. Beall,David B. Witonsky,Geoff Childs,John Novembre,Maniraj Neupane,Sienna R. Craig

Robust activation of microhomology-mediated end joining for precision gene editing applications

Alexey V. Dvornikov,Alvin C. Ma,Carla M. Mann,Drena Dobbs,Gabriel Martínez-Gálvez,Hirotaka Ata,Karl J. Clark,Kyle J. Schaefbauer,Stephen C. Ekker,Thomas L. Ekstrom

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse

Audrey C. Cleuren,David Ginsburg,David R Siemieniak,Emilee N. Kotnik,Guojing Zhu,K？rt Tomberg,Randal J. Westrick,Thomas L. Saunders

Balancing selection on a recessive lethal deletion with pleiotropic effects on two neighboring genes in the porcine genome

Barbara Harlizius,Bert Dibbits,Hendrik-Jan Megens,Marcos S. Lopes,Martien A. M. Groenen,Martijn F. L. Derks,Mirte Bosse,Ole Madsen

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

Cam Patterson,Carrie Rubel,Chang-he Shi,Cheng-yuan Mao,Donte A. Stevens,Hai-Yang Luo,Holly McDonough,Jonathan C. Schisler,Mi-bo Tang,Monte S. Willis,Pan Du,Rebekah Sanchez-Hodge,Richard C. Page,Sabrina C. Madrigal,Sarah E. Soss,Saranya Ravi,Shuo Zhang,Walter J. Chazin,Yao-he Wang,Yu-ming Xu,Yu-sheng Li,Zheng-wei Hu

Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death

Pan Ye,Shan Wang,Xintong Li,Y. Jeffrey Chiang,Ye-Guang Chen,Yehua Li,Yuan Liu,Zhen Qi

Correction: Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

Antonis Rokas,Bo Jacobsson,Britney E. Graham,Bruce Bedell,David A. Hinds,Emily G. Farrow,Frans L. B？dker,Ge Zhang,Haley R. Eidem,Jeffrey C. Murray,Johanna M. Huusko,Kaare Christensen,Kari Teramo,Kelli K. Ryckman,Laura Russell,Louis J. Muglia,Mika R？met,Mikko Hallman,Minna K. Karjalainen,Nadia K. Litterman,Neil A. Miller,Noah W. Brown,Pan-Pan Jiang,Patrick Breheny,Scott M. Williams,Stephen F. Kingsmore,Youna Hu,the 23andMe Research Team

Polynucleotide phosphorylase: Not merely an RNase but a pivotal post-transcriptional regulator

Lisa M. Matz,Nicholas R. De Lay,Todd A. Cameron

Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

Andre Uitterlinden,Andrea Gelemanovic,Archie Campbell,Blair H. Smith,Braxton D. Mitchell,Bruce M. Psaty,Caroline Hayward,Carrie M. Nielson,Cindy G. Boer,Claes Ohlsson,Dan Mellstrom,Daniel S. Evans,Eric Orwoll,Frances M. K. Williams,Gail P. Jarvik,Gordan Lauc,Jerome I. Rotter,Joanne M. Jordan,Joyce B. J. Van Meurs,Lennart Karssen,Liubov Arbeeva,Lynn M. Marshall,Magnus K. Karlsson,Marc Hochberg,Maria Nethander,Maxim B. Freidin,Melody R. Palmer,Michelle S. Yau,Nancy E. Lane,Nicholas L. Smith,Ozren Polasek,Pradeep Suri,Rebecca Jackson,Traci M. Bartz,Tuhina Neogi,Yakov A. Tsepilov,Yurii S. Aulchenko

Rewired RNAi-mediated genome surveillance in house dust mites

Alex Sutton Flynt,Mosharrof Mondal,Pavel Klimov

Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing

Joana Torres,Jorge V. Beira,Renato Paro

The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization

Achim Kramer,Andreas Herrmann,Bert Maier,Franziska Brüning,Lea Ehrhardt,Maria S. Robles,Matthias Mann,Sandra Korge,Thomas Korte

A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa

Bin Wang,Carol S. Ringelberg,Jay C. Dunlap,Jennifer J. Loros,Jillian M. Emerson,Scott A. Gerber,Xiaoying Zhou

Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila

Koichi M. Iijima,Michiko Sekiya,Naoki Fujisaki,Xiuming Quan,Yasufumi Sakakibara

Correction: High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop

Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions

Ben Readhead,Genevieve Beauvais,Justine Bonet,Laurie J. Ozelius,Michelle E. Ehrlich,Pedro Gonzalez-Alegre,Robert D. Blitzer,Thomas P. Zwaka,Tomas Fanutza,Weijia Zhang,Zhengzi Yi,Zuchra Zakirova

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania

Alphaxard Manjurano,Behzad Nadjm,Caroline Maxwell,Christopher J. Drakeley,Eleanor M. Riley,George Mtove,Hannah Wangai,Hugh Reyburn,Matt Ravenhall,Nuno Sepúlveda,Raimos Olomi,Susana Campino,Taane G. Clark,in collaboration with MalariaGEN

Differentially-dimensioned furrow formation by zygotic gene expression and the MBT

J. Todd Blankenship,Yi Xie

MORC2B is essential for meiotic progression and fertility

Baolu Shi,Guanxiang Liang,Jiahao Sha,Jian Zhou,Jiangyang Xue,Mingxi Liu,P. Jeremy Wang,Qinghua Shi,Seth D. Kasowitz,Xiaoyan Huang,Yongjuan Guan,Yuanwei Zhang

WRKY23 is a component of the transcriptional network mediating auxin feedback on PIN polarity

Gergely Molnár,Jakub Hajny,Ji？í Friml,Markus Schmid,Michael Sauer,Mina Vasileva,Ricardo Tejos,Tomá？ Prát,Wim Grunewald

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

Alison A. McBride,Alix Warburton,Catherine J. Redmond,David E. Symer,Haiqing Fu,Katharine E. Dooley,Keiko Akagi,Maura L. Gillison,Mirit I. Aladjem

Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity

Felix Kaufholz,Gordon Wiegleb,Julia Schneider,Montserrat Torres-Oliva,Nico Posnien

Ovule identity mediated by pre-mRNA processing in Arabidopsis

Antonio Martínez-Laborda,Antonio Vera,Encarnación Rodríguez-Cazorla,Héctor Candela,Juan-José Ripoll,Lindsay J. Bailey-Steinitz,Martin F. Yanofsky,Samanta Ortu？o-Miquel

Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide

Alyssa N. King,David E. Heinrichs,David R. Edgell,Jason C. Grigg,Jessica R. Sheldon,Julienne C. Kaiser,Michael E. P. Murphy,Shaun R. Brinsmade

CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory

Amanda Roberts,Chenlu Geng,Dongqing Guo,Hao Xu,Jiye Liu,Shaobing Gao,Shenghui Liang,Tianyu Song,Tingyue Zhang,Yan Feng,Yifei Yin,Yong Cang,Yuchun Gu

DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli

Andrew Robinson,Antoine M. van Oijen,Elizabeth A. Wood,John P. McDonald,Michael M. Cox,Myron F. Goodman,Roger Woodgate,Sarah S. Henrikus

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay

Chelsea M. Karacz,Jenna C. Carlson,John R. Shaffer,Maria I. Morasso,Mary E. Schwartz,Mary L. Marazita,Michael A. Cross,Olivier Duverger

The impact of ribosomal interference, codon usage, and exit tunnel interactions on translation elongation rate variation

Khanh Dao Duc,Yun S. Song

Correction: Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas

Natural variation of piRNA expression affects immunity to transposable elements

Alla Kalmykova,Anastasia Mironova,Elizaveta Radion,Ivan Olovnikov,Maria Y. Kordyukova,Natalia Akulenko,Sergei Ryazansky,Valeriya Morgunova,Yuri Abramov

Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function

Kexin Gai,Qing Dong,Qun He,Xiao Liu,Xuemei Cao,Yashang Wei,Yingchun Liu,Zhaolan Ding

A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling

Chien-Po Liao,Chun-Hao Chen,Chun-Liang Pan,Chun-Wei He

The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium

Alexander Heyl,Cristina Ferrandiz,Dario Paolo,Humberto Herrera-Ubaldo,Ignacio Ezquer,J. Irepan Reyes-Olalde,Joanna Serwatowska,Juan José Ripoll,Karla L. Gonzalez-Aguilera,Lucia Colombo,Martin F. Yanofsky,Nayelli Marsch-Martínez,Patricia Ballester,Paulina Lozano-Sotomayor,Ricardo A. Chavez Montes,Stefan de Folter,Víctor M. Zú？iga-Mayo

Larval crowding accelerates C. elegans development and reduces lifespan

Adam Antebi,Andreas H. Ludewig,Christian Braendle,Clotilde Gimond,Dania C. Pulido,Frank C. Schroeder,Frank D？ring,Joshua C. Judkins,Robert J. Micikas,Staci Thornton

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium

Adebowale Adeyemo,Adesola Ogunniyi,Alan B. Zonderman,Albert M. Levin,Alessandra Chesi,Alex Stram,Andrew Olshan,Anne E. Justice,Babatunde Salako,Babette S. Zemel,Badri Padhukasahasram,Bamidele O. Tayo,Barbara McKnight,Barbara Nemesure,Barry I. Freedman,Benjamin A. Rybicki,Brian E. Cade,Bruce M. Psaty,Chad D. Huff,Charles N. Rotimi,Ching-Ti Liu,Christine B. Ambrosone,Christopher A. Haiman,D. C. Rao,David R. Weir,David S. Siscovick,David V. Conti,Degui Zhi,Dhananjay Vaidya,Diane M. Becker,Donald W. Bowden,Donna K. Arnett,Elisa V. Bandera,Eric Klein,Erin B. Ware,Erwin P. Bottinger,Esther M. John,Guanjie Chen,Hakon Hakonarson,Hayrettin Okut,Ingrid B. Borecki,James G. Wilson,Janet L. Stanford,Jennifer A. Brody,Jennifer A. Smith,Jennifer Hu,Jerome I. Rotter,Jessica D. Faul,Jie Yao,Jin Li,Joel N. Hirschhorn,John Carpten,John S. Witte,Jonathan P. Bradfield,Kari E. North,Katherine L. Nathanson,Kristin Rand,Kristin Young,L. Adrienne Cupples,L. Keoki Williams,Latchezar Dimitrov,Leslie A. Lange,Leslie Bernstein,Lisa R. Yanek,Maggie C. Y. Ng,Marguerite R. Irvin,Mariaelisa Graff,Mary Cushman,Mary F. Feitosa,Mary K. Wojczynski,Matthew A. Allison,Maureen Sanderson,Melissa Garcia,Michael A. Nalls,Michael F. Press,Michele K. Evans,Michele M. Sale,Myriam Fornage,Olufunmilayo I. Oloapde,Phyllis J. Goodman,Poorva Mudgal,Qing Duan,Rebecca Rohde,Regina G. Ziegler,Richard S. Cooper,Rick Kittles,Ruth J. F. Loos,Sailaja Vedantam,Salman M. Tajuddin,Sanjay R. Patel,Sara S. Strom,Sharon L. R. Kardia

Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice

Chiao-Yin Cheng,Han-Sun Chiang,Ya-Yun Wang,Yen-Lin Chen,Yi-No Wu,Ying-Hung Lin,Yung-Chih Lin

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos

Alex P. Reiner,Brian L. Browning,Caitlin P. McHugh,Cathy C. Laurie,Cecilia A. Laurie,Chani J. Hodonsky,Claudia Schurmann,Daniel E. Bauer,Deepti Jain,Diane D. Chen,George Papanicolaou,Jean V. Morrison,Jerome I. Rotter,Kari E. North,Kent D. Taylor,Lisa Brown,Nathan Pankratz,Paul L. Auer,Ruth J. F. Loos,Ryo Kurita,Sharon R. Browning,Tamar Sofer,Timothy A. Thornton,Ursula M. Schick,Yong Mei Liu,Yukio Nakamura,Yun Li

Correction: A Year of Infection in the Intensive Care Unit: Prospective Whole Genome Sequencing of Bacterial Clinical Isolates Reveals Cryptic Transmissions and Novel Microbiota

GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states

Amelia Soto Hopkin,Bogi Andersen,Johann E. Gudjonsson,Lam C. Tsoi,Rachel Herndon Klein,William Gordon,Yun Liang,Ziguang Lin

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness

Angelo Paolo Dei Tos,Claudio Brancolini,Elisa Franforte,Eros Di Giorgio,Harikrishnareddy Paluvai,Maurizio Polano,Monica Brenca,Raffaella Picco,Roberta Maestro,Sabrina Rossi,Sebastiano Cefalù

Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice

Christina Mundy,Eiki Koyama,Federica Sgariglia,Kevin B. Jones,Kristen Carroll,Maurizio Pacifici,Mazen M. Ibrahim,Paul C. Billings,Sayantani Sinha,Till Bechtold

Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo

Marleny Garcia,Rachel L. Gewiss,Shuai Li,Wipawee Winuthayanon