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Archive of "NPJ Aging and Mechanisms of Disease".

ISSN Print: 2056-3973

ISSN Online:

Website: https://www.ncbi.nlm.nih.gov/pmc/journals/3209/

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Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer’s disease

Andrew A. Pieper,Claire M. Erickson,Daniel J. Brat,Jaymie R. Voorhees,Laura M. Dutca,Matthew T. Remy

New drugs for pharmacological extension of replicative life span in normal and progeroid cells

Jaroslaw P. Maciejewski,Sergei Vatolin,Tomas Radivoyevitch

Caveolin-1 as a pathophysiological factor and target in psoriasis

Ilja L. Kruglikov,Philipp E. Scherer

Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system

David Finkelstein,Fabio Demontis,Liam C. Hunt,Maricela Robles-Murguia,Yiping Fan

Publisher Correction: Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Hidetsugu Saito,Kazuki Nogami,Masaki Kimura,Ryoei Uchida,Toshiaki Nakaoka,Toshihide Muramatsu,Yasuhiro Kawase,Yohei Kajiyama,Yoshimasa Saito,Yukana Suzuki

Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction

Adam J. Dobson,Ekin Bolukbasi,Eric Blanc,Matthew D. W. Piper,Mingyao Yang,Xiaoli He,Yodit Feseha

Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging

Beatrix Grubeck-Loebenstein,Giuseppe Del Giudice,Jeffrey J. Stoddard,J？rg J. Goronzy,Paul-Henri Lambert,T. Mark Doherty,Tomas Mrkvan

A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

Alexandre Benedetto,Ann F. Gilliat,Colin T. Dolphin,David Gems,Evgeniy R. Galimov,Hongyuan Wang,Johannes Girstmair,Josephine Hellberg,Marina Ezcurra,Maximilian J. Telford,Trin Athigapanich,Yuan Zhao,Zhizhou Zhang,Ziyu Ren

ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells

Eri Tanaka,Kazuhiko Koike,Kazuma Sekiba,Mari Yamagami,Motoko Ohno,Motoyuki Otsuka,Rei Ishibashi,Takahiro Kishikawa,Takahiro Seimiya,Tatsunori Suzuki

Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4

Deepak Kumar Saini,Raji R. Nair,Shreyas V. Madiwale

Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Hidetsugu Saito,Kazuki Nogami,Masaki Kimura,Ryoei Uchida,Toshiaki Nakaoka,Toshihide Muramatsu,Yasuhiro Kawase,Yohei Kajiyama,Yoshimasa Saito,Yukana Suzuki

Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Dan Alminana,Eric Marcotulli,Leonard Guarente,Mal Evans,Mark Morris,Ryan W. Dellinger,Santiago Roel Santos

The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy

Akira Shimada,Ikuo Inoue,Kaiji Inoue,Mistuhiko Noda,Seiichi Goto,Shinichiro Iida,Takanari Nakano,Yuichi Ikegami,Yuichi Shinoda

CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves

David F. Wozniak,S. Imai,Sean Johnson

Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control

Carole L. Linster,Christian Jaeger,Nicole Paczia,Patrick May,Paul P. Jung,Tomasz Ignac,Zhi Zhang

Blocking negative effects of senescence in human skin fibroblasts with a plant extract

Abdoel El Ghalbzouri,Alix Toribio,Ana？s Tromeur,André Dargen de Matos Branco,Benjamin Sevcnikar,Dominik Autheried,Erwin Tschachler,Florian Gruber,Francois Lejeune,Frédérique Morizot,Hanna Dellago,Ingo L？mmermann,Irina Berlin,Johannes Grillari,Juan Carlos Higareda Almaraz,Lionel Weinberg,Lisa Kleissl,Lucia Terlecki-Zaniewicz,Marcel Scheideler,Marion Rietveld,Markus Schosserer,Nicola Fuzzati,Regina Weinmüllner,Sandra Forestier

Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial

Ayumi Nakamura,Eiji Kiyohara,Hideki Hanaoka,Hiromi Rakugi,Hironori Nakagami,Hiroshi Ando,Ichiro Katayama,Ken Sugimoto,Koichi Yamamoto,Koutaro Yokote,Masaya Koshizaka,Minoru Takemoto,Misa Hayashi,Mitsunori Nishikawa,Takahiro Ishikawa,Taku Fujimoto,Tamotsu Ebihara,Toshifumi Yamaoka,Xiang Jing Yao,Yasushi Takeya,Yoichi Takami,Yuta Terabe

Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress

Chisato Fujimoto,Ken Hayashi,Shinichi Iwasaki,Tatsuya Yamasoba,Teru Kamogashira

Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice

Akio Mitani,Hiroyuki Tada,Kazuto Ishida,Kenji Matsushita,Makoto Hagiwara,Makoto Michikawa,Mohammad Abdullah,Naoyuki Ishida,Taslima Ferdous,Yoshiko Funaki-Kato,Yuichi Ishihara

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Dan Alminana,Eric Marcotulli,Leonard Guarente,Mal Evans,Mark Morris,Ryan W. Dellinger,Santiago Roel Santos

Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells

Aibek Smagul,Aikan A. Akanov,Aliya Nussupbekova,Bryan Krastins,I. King Jordan,Lu Wang,Mary F. Lopez,Maryann Vogelsang,Meenakshi Gaur,Ping Niu,Victoria V. Lunyak,Yueqiang Zhao

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

Alejandro Martin-Montalvo,Aurelia Santoro,Bethany A. Carboneau,Claudio Franceschi,Evi M. Mercken,Husam Khraiwesh,Ilka Wittig,José A. González-Reyes,José M. Villalba,Juliana Heidler,Julie A. Mattison,Kevin G. Becker,Maria Conte,Marta Gonzalez-Freire,Miriam Capri,Rafael de Cabo,Ruin Moaddel,Yongqing Zhang

Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration

Donald F. Ready,Hana Hall,Jeffrey P. Simpson,Vikki M. Weake,Walter D. Leon-Salas,Xinping Chen

How does hormesis impact biology, toxicology, and medicine?

Edward J. Calabrese,Mark P. Mattson

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

Charles E. Hunt,Claude Gronfier,David Sliney,Frederick Marks,Josep Carreras,Kazuo Tsubota,Megumi Hatori,Paul S. Bernstein,Russell N. Van Gelder,Satchidananda Panda,Toshiharu Furukawa,Tsuyoshi Hirota

Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster

Bastiaan J. Zwaan,Jelle Zandveld,Joost van den Heuvel,Matthew D.W. Piper

Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation

Atsushi Haraguchi,Aya Muto,Daisuke Kuriki,Hiroaki Motohashi,Hiroyuki Sasaki,Mayu Yamazaki,Shigenobu Shibata,Takahiro J Nakamura,Takuya Shiraishi,Yosuke Kikuchi,Yu Tahara,Yuta Takatsu

Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality

Akiko Matsumoto,Ge Guo,Haruki Horiguchi,Hiroshi Itoh,Jiabin Zhao,Jun Morinaga,Keishi Miyata,Motoyoshi Endo,Shunshun Zhu,Taichi Sugizaki,Tsuyoshi Kadomatsu,Yuichi Oike,Zhe Tian

SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes

Chisato Inoue,Chong Zhao,Lixiang Wang,Masatoshi Nomura,Miyako Udono,Yoshinori Katakura,Yumi Tsuduki

An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites

Eleonora de Klerk,Laurens Grossouw,Muhammad Riaz,Peter A. C. ’t Hoen,Soheil Yousefi,Tooba Abbassi-Daloii,Vered Raz

Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

Hanna Dellago,Johannes Grillari,Kathrin Garschall,Markus Schosserer,Martina Gáliková,Thomas Flatt

Erratum: Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

Hanna Dellago,Johannes Grillari,Kathrin Garschall,Markus Schosserer,Martina Gáliková,Thomas Flatt

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

Atsumi Soma,Kazuo Tsubota,Masatoshi Hirayama,Miki Sakota,Minoru S.H. Ko,Nana Chikazawa-Nohtomi,Shigeru B.H. Ko,Shigeto Shimmura,Sravan K. Goparaju,Tetsuya Kawakita,Tomohiko Akiyama,Yuhki Nakatake

Neuroprotective role of retinal SIRT3 against acute photo-stress

Eriko Toda,Hideto Osada,Jonathan B. Lin,Kazuo Tsubota,Kenya Yuki,Mitsuhiro Watanabe,Norimitsu Ban,Rajendra S. Apte,Shunsuke Kubota,Yoko Ozawa

Health benefits of late-onset metformin treatment every other week in mice

Alessandra Warren,Christopher Hine,Darisbeth Rosario Lugo,David G. Le Couteur,Hector Mora,Ignacio Navas-Enamorado,Irene Alfaras,James R. Mitchell,Michel Bernier,Rafael de Cabo,Sarah J. Mitchell,Vickie Hoffmann,Victoria C. Cogger

Somatic growth, aging, and longevity

Andrzej Bartke

Message from the new Co-Editor-in-Chief

Shin-ichiro Imai

A glimpse at the aging eye

Jonathan B Lin,Kazuo Tsubota,Rajendra S Apte

It takes two to tango: NAD+ and sirtuins in aging/longevity control

Leonard Guarente,Shin-ichiro Imai

Time distortions in Alzheimer’s disease: a systematic review and theoretical integration

Dimitrios Kapogiannis,Mohamad El Haj

Lifespan-regulating genes in C. elegans

Eisuke Nishida,Masaharu Uno

Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation

Hideyuki Okano,Takuya Shimazaki

Macrophages in age-related chronic inflammatory diseases

Ichiro Manabe,Yumiko Oishi

Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca2+-handling deficits in Alzheimer’s disease models

Caitlin Suire,Chinmoyee Maharana,Dimitrios Kapogiannis,Dong Liu,Emmette R Hutchison,Erez Eitan,Gregory A Jicha,James Comotto,Kenneth W Witwer,Krisztina Marosi,Maja Mustapic,Mark P Mattson,Saket M Nigam,Vasiliki Machairaki

Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function

Akinori Higaki,Bao-Shuai Shan,Harumi Kan-no,Hirotomo Nakaoka,Hui-Yu Bai,Jun Iwanami,Kana Tsukuda,Li-Juan Min,Masaki Mogi,Masatsugu Horiuchi,Masayoshi Kukida,Toshifumi Yamauchi,Toshiyuki Chisaka,Xiao-Li Wang

Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells

Alessandra Lo Cicero,Annachiara De Sandre-Giovannoli,Anne-Laure Egesipe,Anne-Laure Jaskowiak,Claire Navarro,Marc Peschanski,Nicolas Levy,Sophie Blondel,Xavier Nissan

Yeast longevity promoted by reversing aging-associated decline in heavy isotope content

Michael P Snyder,Xiyan Li

Gene expression signatures of human cell and tissue longevity

Inge Seim,Siming Ma,Vadim N Gladyshev

Increased oxidative phosphorylation in response to acute and chronic DNA damage

Alban Longchamp,Bruce S Kristal,Chih-Hao Lee,Dorathy Vargas,Edward Neilan,Humberto Trevi？o-Villarreal,James R Mitchell,Karen Inouye,Kristopher Stanya,Lear E Brace,Pedro Mejia,Roderick T Bronson,Rose M Gathungu,Sarah C Vose,Vasant R Marur

Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism

Harumi Ichimiya,Katsuya Iuchi,Naomi Kamimura,Shigeo Ohta

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