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Archive of "Alzheimer's Research & Therapy".

ISSN Print: 1758-9193

ISSN Online:

Website: https://www.ncbi.nlm.nih.gov/pmc/journals/943/

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Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer’s disease: protocol of the BEAT-IT study

Anke A. Dijkstra,Ellen Singleton,Elsbeth C. Thomeer,Esther van den Berg,Francesco Mattace Raso,Frank Jan de Jong,Jan J. M. Driesen,Jeannette A. Goudzwaard,John C. van Swieten,Lilian J. H. M. Vroegindeweij,Marc Koopmanschap,Michiel Coesmans,Philip Scheltens,Rik Ossenkoppele,Rozemarijn L. van Bruchem,Susanne E. Hoogers,Sytse U. Zuidema,Tom den Heijer,Willem S. Eikelboom,Yolande A. L. Pijnenburg

Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer’s genetic risk

G. Peggy McFall,Kenneth Rockwood,Kirstie McDermott,Sherilyn Thibeau

Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

Alicia Flores-Cuadrado,Alino Martínez-Marcos,Cristina M. Pedrero-Prieto,Daniel Saiz-Sánchez,Francisco J. Alcaín,Isabel úbeda-Ba？ón,Javier Fronti？án-Rubio,José de la Fuente,Lourdes Mateos-Hernández,Margarita Villar,Mario Durán-Prado

Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time

Alexandre Bejanin,Audrey Perrotin,Brigitte Landeau,Béatrice Desgranges,Clémence Tomadesso,Denis Vivien,Elizabeth Kuhn,Géraldine Poisnel,Inès Moulinet,Renaud La Joie,Siya Sherif,Vincent De La Sayette

Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set

Ann C. McKee,Brett Martin,Caroline Labriola,Christian Puzo,Eric G. Steinberg,Jesse Mez,Joseph N. Palmisano,Michael A. Sugarman,Michael L. Alosco,Neil W. Kowall,Robert A. Stern,Ronald J. Killiany,Thor D. Stein,Yorghos Tripodis

Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

Alexandra Polcher,Alfredo Ramirez,Anja Schneider,Annika Spottke,Christoph Laske,Cihan Catak,Claudia Bartels,Coraline Metzger,Daniel Janowitz,Dix Meiberth,Eike Spruth,Emrah Düzel,Enise Incesoy,Felix Menne,Frank Jessen,Frederic Brosseron,Ingo Kilimann,Jens Wiltfang,Josef Priller,Julia Utecht,Katharina Buerger,Katja Luther,Klaus Fliessbach,Laura Dobisch,Lisa Miebach,Martina Buchmann,Michael T. Heneka,Nina Roy,Oliver Peters,Pascal Kalbhen,Robert Perneczky,Slawek Altenstein,Stefan J. Teipel,Steffen Wolfsgruber

Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review

Ant？nio Lúcio Teixeira,Elizabeth Sakamoto Valente,Henrique Cerqueira Guimar？es,Leandro Boson Gambogi,Luciano Inácio Mariano,Paulo Caramelli

Correction to: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Akitoyo Hishimoto,Doyle Lu Lang,Josephine M. Egan,Juan C. Troncoso,Olga Pletnikova,Qing-Rong Liu

Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease

Alberto Lleó,Carlos A. Saura,Cristina Fábregas,Dolores Siedlecki-Wullich,Isabel Hernández,Jordi Clarimon,José Rodríguez-álvarez,Judit Català-Solsona,Merce Boada

Risk of suicide and accidental deaths among elderly patients with cognitive impairment

Hong Jin Jeon,Ji Hyun An,Kyung Eun Lee,Sang Joon Son,Sung Yoon Kim

Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort

André Aleman,Craig W. Ritchie,Esther M. Opmeer,Frank Jan de Jong,John E. Harrison,Philip Scheltens,Philippe R. Lee Meeuw Kjoe,R. A. J. van Deelen,R. Vreeswijk,Roos J. Jutten,Silvia Ingala

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Christian B. Lessard,Jamie Bilsland,Lorenza Magno,Marta Martins,Matilda Katan,Paramita Chakrabarty,Pedro Cruz,Tammaryn Lashley,Todd E. Golde,Verena Lang,Yasmine Asi

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Alessandro Padovani,Andrea Pilotto,Arianna Sala,Giuseppe Magnani,Leonardo Iaccarino,Luca Beretta,Luigi Ferini-Strambi,Luigi Gianolli,Sandro Iannaccone,Silvia Paola Caminiti

Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings

Alexander Pantelyat,Andrew Siderowf,Angela Lunde,Angela Taylor,Bethany Peterson,Carol Lippa,Carol Manning,Charbel Moussa,Chiadi Onyike,Daniel Huddleston,Daniel Kaufer,David Irwin,Douglas Galasko,Douglas Scharre,Fernando Pagan,Henry Paulson,Holly Shill,Ian G. McKeith,Ian Richards,Irene Litvan,Irene Richard,James E. Galvin,James Leverenz,Jennifer Goldman,John Duda,Joseph Quinn,Karen Marder,Katherine Amodeo,Kathleen Poston,Kimiko Domoto-Reilly,Lawrence Honig,Liana S. Rosenthal,Marwan Sabbagh,Matt Barrett,Melissa Armstrong,Mike Koehler,Neill Graff-Radford,Samantha Holden,Sharon Sha,Stephen Gomperts,Tina Christie,Todd Graham,Victoria Pelak,Yasar Torres-Yaghi

Avoiding methodological bias in studies of amyloid imaging results disclosure

Andrea G. Louey,Carl Taswell,Cheryl Donohue,Colin L. Masters,David G. Darby,Jacqueline Giummarra,Joanne Robertson,Maree T. Mastwyk

Prevalence and risk of progression of preclinical Alzheimer’s disease stages: a systematic review and meta-analysis

Elena Chipi,Katia D’Andrea,Lucilla Parnetti,Nicola Salvadori

Measuring instrumental activities of daily living in non-demented elderly: a comparison of the new performance-based Harvard Automated Phone Task with other functional assessments

David A. Loewenstein,Gad A. Marshall,Joseph J. Locascio,Kamal Jethwani,Keith A. Johnson,Maria Dekhtyar,Rebecca E. Amariglio,Reisa A. Sperling,Sara J. Czaja,Sarah L. Aghjayan

Concepts for brain aging: resistance, resilience, reserve, and compensation

Brenna A. Cholerton,Claudia H. Kawas,Laura S. Hemmy,Margaret E. Flanagan,Maria M. Corrada,Steven D. Edland,Thomas J. Montine

Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer’s disease

Barbara Mroczko,Daniela Vieira,Diana Duro,Inês Baldeiras,Isabel Santana,Johannes Kornhuber,Maria Jo？o Leit？o

Data-driven prognostic features of cognitive trajectories in patients with amnestic mild cognitive impairments

Changsoo Kim,Duk L. Na,Hee Jin Kim,Jacob W. Vogel,Jin San Lee,Juyoun Lee,Seong-Kyoung Cho,Yeo Jin Kim,Young Kyoung Jang

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study

Anders Paetau,Anette Hall,Hilkka Soininen,Jussi Mattila,Jyrki L？tj？nen,Liisa Myllykangas,Maarit Tanskanen,Mark van Gils,Mia Kero,Miia Kivipelto,Minna Oinas,Mira M？kel？,Timo Pekkala,Tuomo Polvikoski

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

Anna Wilkinson,Asma Bashir,Carlos J. Barron,Dhananjay R. Namjoshi,Ebrima Gibbs,Emily B. Button,Honor Cheung,Kris M. Martens,Neil R. Cashman,Peter A. Cripton,Sophie Stukas,Wai Hang Cheng

Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study

Afina W. Lemstra,Anne M. Remes,Antti Tolonen,Birgitte B. Andersen,Daniel Rueckert,Gunhild Waldemar,Hanneke F. M. Rhodius-Meester,Hilkka Soininen,Juha Koikkalainen,Jyrki L？tj？nen,Kristian S. Frederiksen,Le Gjerum,Marie Bruun,Mark van Gils,Marta Baroni,Merja Hallikainen,Nadia Dyremose,Patrizia Mecocci,Sanna-Kaisa Herukka,Sudhir Kurl,Timo Urhemaa,Wiesje M. van der Flier

Risk of dementia in patients with end-stage renal disease under maintenance dialysis—a nationwide population-based study with consideration of competing risk of mortality

Chien-Yao Sun,Chiung-Chih Chang,Chung-Yi Li,Jia-Ling Wu,Junne-Ming Sung,Yi-Ting Kuo,Yu-Tzu Chang

Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort

Anna Brugulat-Serrat,Carles Falcon,Carole H. Sudre,Frederik Barkhof,Gemma Salvadó,José Luis Molinuevo,Karine Fauria,M. Jorge Cardoso,Marc Suárez-Calvet,Oriol Grau-Rivera,for the ALFA Study

Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Bruno Dubois,Enrica Cavedo,Fatemah A. Sakr,Gabriel Gonzalez-Escamilla,Hugo Bertin,Irina Jelistratova,Marie-Odile Habert,Martin Dyrba,Maxime Locatelli,Michel J. Grothe,Stefan Teipel,Stephane Lehericy,for the INSIGHT-preAD study group,the Alzheimer Precision Medicine Initiative (APMI)

Safety and tolerability of donepezil 23？mg with or without intermediate dose titration in patients with Alzheimer’s disease taking donepezil 10？mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial

Dong Won Yang,Hwa Jung Kim,Hyun Jeong Han,Ji Eun Kim,Kyung Won Park,SangYun Kim,Young Chul Youn,Yun Jeong Hong,on behalf of the ODESA study (Optimal Dose Escalation Strategy to Successful Achievement of High Dose Donepezil 23 mg)

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease

Anne M. Landau,Athanasios Metaxas,Marco Anzalone,Ramanan Vaitheeswaran,Sussanne Petersen

Brief cognitive screening instruments for early detection of Alzheimer’s disease: a systematic review

Ellen Elisa De Roeck,Eva Dierckx,Peter Paul De Deyn

Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease

Henrik Zetterberg,Markus Otto,Oskar Hansson,Sylvain Lehmann

Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer’s disease

Alexander Foulkes,Catherine F. Slattery,Femke H. Bouwman,Frank D. Verbraak,Imre Lengyel,Jonathan M. Schott,Jurre den Haan,Lajos Csinscik,Philip Scheltens,Ross W. Paterson,Sebastian J. Crutch,Timothy J. Shakespeare,Tom Parker,Tunde Peto

Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau

Andreas Zwergal,Andrei Leonov,Armin Giese,Barbara von Ungern-Sternberg,Christian Griesinger,Federico Probst,Felix Overhoff,Finn Peters,Guido Boening,Igor Yakushev,Jochen Herms,Johannes Levin,Lena Kaiser,Matthias Brendel,Maximilian Deussing,Paul Cumming,Peter Bartenstein,Sergey Ryazanov,Sibylle Ziegler,Tanja Blume

Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers

Frank Jessen,Haoming Dong,Jie Lu,Michael Ewers,Tohar Scheininger,Xi-Nian Zuo,Ying Han,Yinshan Wang,Yu Sun

Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer’s disease spectrum

Denise Visser,Emma E. Wolters,Frederik Barkhof,Philip Scheltens,Rik Ossenkoppele,Ronald Boellaard,Sandeep S. V. Golla,Sander C. J. Verfaillie,Tessa Timmers,Wiesje M. van der Flier

18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

Adam L. Boxer,Adrienne Visani,Alexandre Bejanin,Anna Karydas,Bruce L. Miller,David C. Perry,Eliana M. Ramos,Giovanni Coppola,Howard J. Rosen,James P. O’Neil,Lea T. Grinberg,Lynn Bajorek,Maria Luisa Gorno-Tempini,Mustafa Janabi,Orit Lesman-Segev,Renaud LaJoie,Richard M. Tsai,Salvatore Spina,Suzanne Baker,Suzee E. Lee,Viktoriya Bourakova,William Jagust,William W. Seeley

Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer’s disease

Claus Thamer,Glen Wunderlich,Lutz Fr？lich,Michael Roehrle,Miguel Garcia, Jr

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities

Alireza Nazarian,Anatoliy I. Yashin

Prevalence of abnormal Alzheimer’s disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples

Alexander Drzezga,Annika Spottke,Charlotte E. Teunissen,Christoph Laske,Emrah Düzel,Femke H. Bouwman,Jens Wiltfang,Josef Priller,José Luis Molinuevo,Katharina Buerger,Katja Luther,Linda M. P. Wesselman,Lorena Rami,Michael T. Heneka,Michael Wagner,Nina Coll-Padrós,Oliver Peters,Rosalinde E. R. Slot,Sietske A. M. Sikkes,Stefan Teipel,Steffen Wolfsgruber,Wiesje M. van der Flier,on behalf of the Euro-SCD working group

CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease

Adla Boumenir,Aline Dugravot,Archana Singh-Manoux,Claire Hourregue,Claire Paquet,Elodie Bouaziz-Amar,Emmanuel Cognat,Jacques Hugon,Jean-Louis Laplanche,Matthieu Lilamand,Severine Sabia

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Hui Song,Jie Xiang,Kun Cao,Long-Yan Ran,Wei Hong,Xiao-Xiao Zeng,Yang-Ting Dong,Yi Li,Yi Xu

Reversible predictors of reversion from mild cognitive impairment to normal cognition: a 4-year longitudinal study

Hiroyuki Shimada,Sangyoon Lee,Takehiko Doi

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

Aida Ni？erola-Baizán,Andrés Perissinotti,Anna Brugulat-Serrat,Carles Falcon,Carolina Minguillon,Francisco Lome？a,Gemma Salvadó,Henrik Zetterberg,Javier Pavia,José Luis Molinuevo,Kaj Blennow,Karine Fauria,Marc Suárez-Calvet,Oriol Grau-Rivera,for the Alzheimer’s Disease Neuroimaging Initiative, for the ALFA Study

Response to “Avoiding Methodological Bias in Studies of Amyloid Imaging Results Disclosure”

Chelsea G. Cox,Jason Karlawish,Joshua D. Grill,Kristin Harkins

Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA

Caroline V. Greaves,Charles R. Marshall,David M. Cash,Jason D. Warren,Juan Eugenio Iglesias,Lucy L. Russell,Martina Bocchetta,Marzia A. Scelsi,Sebastien Ourselin

Tau and atrophy: domain-specific relationships with cognition

Anders M. Dale,Emilie T. Reas,James B. Brewer,John R. Madsen,Leonardino A. Digma,for the Alzheimer’s Disease Neuroimaging Initiative

Further analyses of the safety of verubecestat in the phase 3 EPOCH trial of mild-to-moderate Alzheimer’s disease

Bruno Vellas,Christine Furtek,Christopher Lines,Erin Mahoney,James Kost,Jeffrey L. Cummings,Julie Stone,Michael F. Egan,Paul S. Aisen,Pierre N. Tariot,Tiffini Voss,Yuki Mukai

An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

Abhinaba Ghosh,Bandhan Mukherjee,Carolyn W. Harley,Gerard M. Martin,Sarah E. Torraville,Susan G. Walling

Towards a unified protocol for handling of CSF before β-amyloid measurements

Britta Brix,Erik Stomrud,Shorena Janelidze

Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Esko Lev？lahti,Hilkka Soininen,Jaakko Tuomilehto,Juha Hulkkonen,Juha Koikkalainen,Juha Rinne,Jyrki L？tj？nen,Miia Kivipelto,Nina Kemppainen,Pauliina Pippola,Riitta Antikainen,Riitta Parkkola,Ritva Vanninen,Ruth Stephen,Tiia Ngandu,Timo Strandberg,Yawu Liu,for the FINGER study group

FDG-PET as an independent biomarker for Alzheimer’s biological diagnosis: a longitudinal study

Jie-Qiong Li,Ke-Liang Chen,Lan Tan,Mei Cui,Qiang Dong,Wei Xu,Ya-Nan Ou,Yu Guo,Yu-Yuan Huang,on behalf of Alzheimer’s Disease Neuroimaging Initiative

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