The bystander effect contributes to the accumulation of senescent cells in vivo

Abbas Ishaq,Gabriele Saretzki,Glyn Nelson,Julien Glibert,Kerry Cameron,Mikolaj Ogrodnik,Olena Kucheryavenko,Paulo F. L. da Silva,Satomi Miwa,Sushma Nagaraja‐Grellscheid

Conservation of physiological dysregulation signatures of aging across primates

Alan A. Cohen,Gabriel Dansereau,Joseph W. Kemnitz,Luigi Ferrucci,Marie A. Brunet,Véronique Legault

Long‐term intake of phenolic compounds attenuates age‐related cardiac remodeling

Jean‐Fran？ois Faivre,Joelle Hajal,Nicolas Louka,Patrick Bois,Richard G. Maroun,Stéphanie Chacar,Youakim Saliba

sFRP3 inhibition improves age‐related cellular changes in BubR1 progeroid mice

Alfredo Oliveros,Chang Hoon Cho,Jan M. van Deursen,Ki Hyun Yoo,Summer Paulson,Syed Mohammed Qasim Hussaini

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Christopher Stuart Garris,David Lieb,James M. Heather,Raktima Raychowdhury,Thomas Eisenhaure,Yuk Yuen Lan

Identification of stable senescence‐associated reference genes

Alejandra Hernandez‐Segura,Richard Rubingh

Circumventing senescence is associated with stem cell properties and metformin sensitivity

Benjamin Le Calvé,Emmanuelle Saint‐Germain,Filippos Kottakis,Karine Moineau‐Vallée,Marie‐Camille Rowell,Maxime Parisotto,Nabeel Bardeesy,Paloma Kalegari,Sebastian Igelmann,Véronique Bourdeau,Xavier Deschênes‐Simard

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

Hanna Salmonowicz,Mikolaj Ogrodnik

Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging

Fatemeh Adelnia,Kai Sun,Kenneth Fishbein,Luigi Ferrucci,Marta Gonzalez‐Freire,Michelle Shardell,Mohammed Khadeer,Nicholas Brennan,Norman Salem, Jr,Pingbo Zhang,Richard G. Spencer,Ruin Moaddel

LncRNAs regulating stemness in aging

António Sousa‐Franco,Kenny Rebelo,Sim？o Teixeira da Rocha

Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

Christoph Peters,Hong Qing,Jie Meng,Junjun Ni,Veronika Stoka,Vito Turk,Yoshinori Hayashi,Zhou Wu

Reconciling nutritional geometry with classical dietary restriction: Effects of nutrient intake, not calories, on survival and reproduction

Elizabeth Heap,Fiona Moon,Joshua P. Moatt,Luke J. M. Mitchell,Murray A. Fyfe

Amyloid β‐induced elevation of O‐GlcNAcylated c‐Fos promotes neuronal cell death

Chaeyoung Kim,Haeng Jun Kim,Heesun Choi,Hyun Jin Cho,Hyundong Song,Moon‐Yong Cha,Sung Min Son

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

Albert Giralt,Claire Paquet,Eliane Meurs,Fran？ois Mouton Liger,Jean‐Antoine Girault,Julien Schmitt,Karim Farid,Laure Rondi Reig,Marion Tible,Sarah Gourmaud,Sylvie Thomasseau

DAF‐16 stabilizes the aging transcriptome and is activated in mid‐aged Caenorhabditis elegans to cope with internal stress

Ao‐Lin Hsu,Chung‐Yi Liang,Han‐Qing Zhao,Pan Zhang,Shang‐Tong Li,Yan‐Ping Zhang

The exceptional longevity of the naked mole‐rat may be explained by mitochondrial antioxidant defenses

Cécile Baldy,Jason R. Treberg,Matthew E. Pamenter

Caloric restriction controls stationary phase survival through Protein Kinase A (PKA) and cytosolic pH

Laura Dolz‐Edo,Margaretha van der Deen,Stanley Brul

Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease

Swarnaseetha Adusumalli,Touati Benoukraf,Wei‐Qi Lin,Zhen‐Kai Ngian

Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization

Adrián Martín‐Segura,Axelle Kerstens,Detlef Balschun,Ernest Palomer,Irene Palomares‐Perez,Sebastian Munck,Tariq Ahmed,álvaro Casadomé‐Perales

Astrocyte senescence: Evidence and significance

Justin Cohen

Decoy fitness peaks, tumor suppression, and aging

Kelly C. Higa

Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF‐1 pathway

Bo Ding,Tanika T. Williamson,Xiaoxia Zhu

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

Aled J. Parry,Jane C. Goodall,Kimberley A. Wiggins,Liam D. Cassidy,Masashi Narita,Melanie Humphry,Steve J. Webster

Hyperadrenocorticism of calorie restriction contributes to its anti‐inflammatory action in mice

Brian D. Allen,Chen‐Yu Liao,Jianhua Shu,Joseph A. Majzoub,Louis J. Muglia,Vivian Diaz

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

Aleksey Matveyenko,Allyson K. Palmer,Christine M. Hachfeld,Diana Jurk,Edgar A. Arriaga,Eduardo N. Chini,Esther Verkade,Ewald J. Doornebal,Folkert Kuipers,Grace Casaclang‐Verzosa,Hajrunisa Cubro,Jordan D. Miller,Joseph Grande,Judith Campisi,Kurt O. Johnson,LaTonya J. Hickson,Larissa G. Prata,Marco Demaria,Marissa J. Schafer,Megan M. Weivoda,Michael B. Stout,Michael D. Jensen,Mikolaj Ogrodnik,Ming Xu,Nathan K. LeBrasseur,Tamar Pirtskhalava,Tamar Tchkonia,Theo H. van Dijk,Thomas A. White,Thomas von Zglinicki,Vesna Garovic,Yi Zhu

Transcription factor networks in aged na？ve CD4 T cells bias lineage differentiation

Bin Hu,Claire E. Gustafson,Cornelia M. Weyand,Guangjin Li,Lu Tian,Zhongde Ye

Cav1.2 regulates osteogenesis of bone marrow‐derived mesenchymal stem cells via canonical Wnt pathway in age‐related osteoporosis

Anqi Liu,Bei Li,Dongdong Fei,Hui Zhang,Jinjin Wang,Junjie Wu,Qintao Wang,Xiaoning He,Yang Zhang

CpG‐related SNPs in the MS4A region have a dose‐dependent effect on risk of late–onset Alzheimer disease

Adam C. Naj,Alzheimer’s Disease Genetics Consortium,Brian W. Kunkle,Charles C. White,David A Bennett,Gerard D. Schellenberg,Gyungah R. Jun,Jaeyoon Chung,Jonathan L. Haines,Kathryn L. Lunetta,Lindsay A. Farrer,Margaret A. Pericak‐Vance,Philip L. De Jager,Richard Mayeux,Xiaoling Zhang

Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies

Baian Chen,Jianping Jia,Jing Lu,Jing Zhang,Liming Zhu,Qiao Zhao,Quan Sun,Shubo Wang,Wei Qin,Yanhua Qiao,Yi Wu,Zitong Yao

Age‐dependent changes and biomarkers of aging in Caenorhabditis elegans

Eun Ji E. Kim,Heehwa G. Son,Ozlem Altintas,Sujeong Kwon

Functional pathways regulated by microRNA networks in CD8 T‐cell aging

Claire E. Gustafson,Cornelia M. Weyand,Jun Jin,Mary M. Cavanagh

The leptin sensitizer celastrol reduces age‐associated obesity and modulates behavioral rhythms

Isaac J. Perron,Karthikeyani Chellappa,Nirinjini Naidoo

Genetically heterogeneous mice exhibit a female survival advantage that is age‐ and site‐specific: Results from a large multi‐site study

Catherine J. Cheng,Jonathan A. L. Gelfond,Randy Strong

Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a

Alfred Li,Cheol Hwangbo,Jin‐Na Min,Maor Sauler,Peiying Shan,So‐Jin Kim,Taylor Ardito,Tien Peng,Xuchen Zhang,Yi Zhang

Long‐term caloric restriction ameliorates deleterious effects of aging on white and brown adipose tissue plasticity

Adriana Izquierdo‐Lahuerta,Carmen Martínez,Daniel Horrillo,Ismael Velasco,Lucia Torres,Manuel Ros,Maria Jesus Obregon,Miguel López,Patricia Corrales,Patricia Seoane‐Collazo,Yamila Lopez,Yurena Vivas

Nontuberculous mycobacterium M.？avium infection predisposes aged mice to cardiac abnormalities and inflammation

Abigail Gerberick,Colwyn A. Headley,Joanne Turner,Latha Prabha Ganesan,Lianbo Yu,Mahmood Khan,Paolo Fadda,Qian Wu,Sumiran Mehta

NAD+ supplementation rejuvenates aged gut adult stem cells

Eric Williams,Frank Jaksch,Masaki Igarashi,Masaomi Miura,Takashi Kadowaki,Toshimasa Yamauchi

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long‐lived Myc hypomorphic mice

Abigail L. Peterson,Anna P. Petrashen,Jennifer A. Sanders,Xiaoai Zhao

Alogliptin improves survival and health of mice on a high‐fat diet

Bei Guo,Biao Zhu,Huan Li,Jiajia Zhang,Jing Dong,Li Wang,Lin Xiang,Lingwei Xiang,Long Chen,Min Liu,Minglu Liang,Wen Mei,Yixiang Li

Announcement

Corrigendum

Corrigendum

1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling

David Goltzman,Jie Chen,Li Mao,Lulu Chen,Renlei Yang,Wanxin Qiao,Wei Zhang

Sirt1–hypoxia‐inducible factor‐1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

Dong Ryeol Ryu,Hyoungnae Kim,Hyunjin Noh,Jin Seok Jeon,Kyoung Hye Kong,Mi Ra Yu,Soon Hyo Kwon

Corrigendum

Inhibition of nucleolar stress response by Sirt1: A potential mechanism of acetylation‐independent regulation of p53 accumulation

Daoyuan Li,Qing Ye,Qisheng Peng,Qunye Zhang,Xiao Wu,Xiaolei Bi,Yun Zhang,Zhe Wang

Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR‐125b pathway

Dan Liu,Ding‐Qi Wang,Hasan.a.m.m. Almansoub,Hengye Man,He‐Zhou Huang,Hui Tang,Lan‐Ting Zhou,Ling‐Qiang Zhu,Man‐Fei Deng,Mei Ma,Na Wei,Ying Wu,Youming Lu

Are skin senescence and immunosenescence linked within individuals?

David A. Gunn,David Goldeck,Diana van Heemst,Graham Pawelec,Mari？tte E. C. Waaijer,Rudi G. J. Westendorp

Telomere length and telomerase activity in T cells are biomarkers of high‐performing centenarians

Andrew T. Ludlow,Beatrice Arosio,Daniela Mari,Ejun Huang,Enzo Tedone,Kimberly Batten,Ryan O’Hara,Tsung‐Po Lai,Woodring E. Wright

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

Garrett L. Cornelison,Simon A. Levy,Tyler Jenson