Editorial Board

Biography

Dr. Stephen L. Chan

Department of Clinical Oncology, The Chinese University of Hong Kong, China
Email: chanlam_stephen@cuhk.edu.hk

Qualifications

MBBS (HKU); MRCP (UK), FRCP (Edin), FHKCP, FHKAM (Medicine)

Publications (Selected)

  1. Chan, L. L., Chan, A. W., Yip, T. C., Wong, G. L., Ngai, A. K., Mo, F., ... & Chan, S. L. (2025). Attenuation of the second peak of bimodal recurrence of HBV-related HCC after curative treatment in the antiviral era. Journal of Hepatology.
  2. Ma, M. J. L., Zhang, W. Z., Jiang, P., Ji, L., Xiong, D., Peng, W., ... & Lo, Y. D. (2025). Chromatin accessibility states affect transrenal clearance of plasma DNA: Implications for urine-based diagnostics. Med.
  3. Chen, L. M., Simon, C. H., Leung, L., Hui, E. P., Yeo, W., & Chan, S. L. (2025). Liver-and tumour-specific indicators predicting suboptimal survival following repeat transarterial chemoembolisation in patients with hepatocellular carcinoma. Hong Kong Medical Journal, 31(1), 32.
  4. Zhu, G., Jiang, P., Li, X., Peng, W., Choy, L. L., Yu, S. C., ... & Lo, Y. D. (2024). Methylation-Associated Nucleosomal Patterns of Cell-Free DNA in Cancer Patients and Pregnant Women. Clinical Chemistry, 70(11), 1355-1365.
  5. Chan, L. L., Yeung, V. T., Mo, F., Poon, D. M., Tong, M., Mok, F. S., ... & Chan, S. L. (2024). 336: Radiation-induced lymphopenia predicts poor survival in HCC patients treated with radiotherapy. Radiotherapy and Oncology, 194, S2133-S2137.
  6. Chan, Stephen L., Baek-Yeol Ryoo, Frankie Mo, Landon L. Chan, Jaekyung Cheon, Leung Li, Kwan H. Wong, Nicole Yim, Hyeyeong Kim, and Changhoon Yoo. "Multicentre phase II trial of cabozantinib in patients with hepatocellular carcinoma after immune checkpoint inhibitor treatment." Journal of Hepatology 81, no. 2 (2024): 258-264.
  7. Cheon, Jaekyung, Sanghoon Jung, Jung Sun Kim, Beodeul Kang, Hyeyoung Kim, Landon L. Chan, Lars Becker et al. "Organ‐specific responses to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma: A multicentre, retrospective study." Liver International 44, no. 8 (2024): 1961-1970.
  8. Che, Huiwen, Peiyong Jiang, LY Lois Choy, Suk Hang Cheng, Wenlei Peng, Rebecca WY Chan, Jing Liu et al. "Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma." Genome Research 34, no. 2 (2024): 189-200.
  9. Liu, Yuting, Shing Chun Tang, Chi Han Li, Ka Fai To, Bo Li, Stephen Lam Chan, Chi Hin Wong, and Yangchao Chen. "The molecular mechanism underlying KRAS regulation on STK31 expression in pancreatic ductal adenocarcinoma." Cancer Science 115, no. 10 (2024): 3288-3304.
  10. Chan, KC Allen, WK Jacky Lam, Ann King, Vivien S. Lin, Patrick PH Lee, Benny CY Zee, Stephen L. Chan et al. "Plasma Epstein–Barr virus DNA and risk of future nasopharyngeal cancer." NEJM evidence 2, no. 7 (2023): EVIDoa2200309.
  11. Zhou, Ze, Mary-Jane L. Ma, Rebecca WY Chan, WK Jacky Lam, Wenlei Peng, Wanxia Gai, Xi Hu et al. "Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs." Proceedings of the National Academy of Sciences 120, no. 17 (2023): e2220982120.
  12. Zhou, Qing, Guannan Kang, Peiyong Jiang, Rong Qiao, WK Jacky Lam, Stephanie CY Yu, Mary-Jane L. Ma et al. "Epigenetic analysis of cell-free DNA by fragmentomic profiling." Proceedings of the National Academy of Sciences 119, no. 44 (2022): e2209852119.
  13. Ng, Kelvin KC, Nicole MY Cheng, Hon-Ting Lok, Janet WC Kung, Andrew KY Fung, and Stephen L. Chan. "Is hepatic resection justified for non-colorectal non-neuroendocrine liver metastases? A systematic review and meta-analysis." The Surgeon 21, no. 3 (2023): 160-172.
  14. Choy, LY Lois, Wenlei Peng, Peiyong Jiang, Suk Hang Cheng, Stephanie CY Yu, Huimin Shang, O. Y. Olivia Tse et al. "Single-molecule sequencing enables long cell-free DNA detection and direct methylation analysis for cancer patients." Clinical Chemistry 68, no. 9 (2022): 1151-1163.
  15. Chan, Stephen L., Paul NM Cheng, Angela M. Liu, Landon L. Chan, Leung Li, Cheuk M. Chu, Charing CN Chong et al. "A phase II clinical study on the efficacy and predictive biomarker of pegylated recombinant arginase on hepatocellular carcinoma." Investigational New Drugs 39 (2021): 1375-1382.
  16. Vong, Joaquim SL, Lu Ji, Macy MS Heung, Suk Hang Cheng, John Wong, Paul BS Lai, Vincent WS Wong et al. "Single cell and plasma RNA sequencing for RNA liquid biopsy for hepatocellular carcinoma." Clinical Chemistry 67, no. 11 (2021): 1492-1502.
  17. Tse, OY Olivia, Peiyong Jiang, Suk Hang Cheng, Wenlei Peng, Huimin Shang, John Wong, Stephen L. Chan et al. "Genome-wide detection of cytosine methylation by single molecule real-time sequencing." Proceedings of the National Academy of Sciences 118, no. 5 (2021): e2019768118.
  18. Feng, Xiaobin, Lin Zhang, Huimin Niu, Hui Zhang, Li Yang, Yong Wen, Steve Y. Chen et al. "Selective internal radiation therapy with yttrium‐90 resin microspheres followed by anatomical hepatectomy: A potential curative strategy in advanced hepatocellular carcinoma." Asia‐Pacific Journal of Clinical Oncology 20, no. 2 (2024): 319-322.
  19. Gai, Wanxia, Ze Zhou, Sean Agbor-Enoh, Xiaodan Fan, Sheng Lian, Peiyong Jiang, Suk Hang Cheng et al. "Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology." Elife 10 (2021): e64356.
  20. Jiang, Peiyong, Tingting Xie, Spencer C. Ding, Ze Zhou, Suk Hang Cheng, Rebecca WY Chan, Wing-Shan Lee et al. "Detection and characterization of jagged ends of double-stranded DNA in plasma." Genome research 30, no. 8 (2020): 1144-1153.
  21. Wong, Chi Hin, Ut Kei Lou, Youjia Li, Stephen L. Chan, Joanna HM Tong, Ka-Fai To, and Yangchao Chen. "CircFOXK2 promotes growth and metastasis of pancreatic ductal adenocarcinoma by complexing with RNA-binding proteins and sponging MiR-942." Cancer research 80, no. 11 (2020): 2138-2149.
  22. Chong, Charing CN, Kit F. Lee, Sunny YS Cheung, Clement CM Chu, Anthony KW Fong, John Wong, Joyce WY Hui et al. "Prospective double-blinded randomized controlled trial of Microwave versus RadioFrequency Ablation for hepatocellular carcinoma (McRFA trial)." Hpb 22, no. 8 (2020): 1121-1127.
  23. Han, Guohong, Sarah Berhane, Hidenori Toyoda, Dominik Bettinger, Omar Elshaarawy, Anthony WH Chan, Martha Kirstein et al. "Prediction of survival among patients receiving transarterial chemoembolization for hepatocellular carcinoma: a response‐based approach." Hepatology 72, no. 1 (2020): 198-212.


Profile Details

https://www.med.cuhk.edu.hk/staff/professor-chan-lam-stephen

https://scholar.google.com/citations?user=vx-sVaIAAAAJ&hl=en

https://www.researchgate.net/profile/Stephen-Chan-10

https://orcid.org/0000-0001-8998-5480