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Search Results: 1 - 10 of 12143 matches for " Low dose magnesium sulphate (Dhaka) regime "
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Vidyadhar B Bangal,Purushottam A. Giri,Satyajit P. Gavhane
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i1.218
Abstract: Background: Eclampsia is a hypertensive disorder related to pregnancy, in which there is occurrence of one or more generalized convulsions and or coma, in the absence of other neurologic conditions. It is a common obstetric emergency. Eclampsia is associated with elevated maternal and fetal morbidity and mortality. Objectives: To compare the efficacy of low dose magnesium sulphate (Dhaka) regime with Pritchard regime in Eclampsia. Material and Methods: A prospective randomized study of fifty eclampsia cases, treated with magnesium sulphate (25 each from low dose magnesium sulphate (Dhaka) regime and Pritchard regime) was carried out for one year i.e. January 2010 to December 2010 at Pravara Rural Hospital, Loni. Results were analysed using Statistical Package of Social Sciences (SPSS) 13.0. Results: In the present study, convulsions were controlled in 88% of eclampsia cases with low dose magnesium sulphate (Dhaka) regime. Two cases i.e. 8% had single episode of recurrence of convulsion, which was controlled by giving additional 2 grams of 20% magnesium sulphate intravenous single dose. Perinatal mortality in low dose magnesium sulphate (Dhaka) regime was lesser (24%) than Pritchard regime (32%). Conclusion: Low dose magnesium sulphate (Dhaka) regime was equally effective as Pritchard regime in control of eclamptic convulsions. There was no magnesium related toxicity with low dose magnesium sulphate (Dhaka) regime. Maternal and perinatal outcome was better in low dose magnesium sulphate (Dhaka) regime as compared to Pritchard regime. Key words: Low dose magnesium sulphate (Dhaka) regime, Pritchard regime, Eclampsia, Maternal and foetal outcome
Bangal V,Kwatra A,Raghav S,Jadhav S
Pravara Medical Review , 2009,
Abstract: Pre- eclampsia is one of the commonest medical complications seen during pregnancy. It contributes significantly to maternal and perinatal morbidity and mortality. Dr.J.A.Pritchard in 1955, introduced magnesium sulphate for control of convulsions in eclampsia and is used worldwide. Considering the low body mass index of indian women, a low dose magnesium sulphate regime has been introduced by some authors. Present study was carried out at tertiary care centre in rural area. Fifty cases of eclampsia were randomly selected to find out the efficacy of low dose magnesium sulphate regime to control eclamptic convulsions. Maternal and perinatal outcome and magnesium toxicity were analyzed. It was observed that 86% cases responded to initial intravenous dose of 4 grams of 20% magnesium sulphate . Eight percent cases, who got recurrence of convulsion, were controlled by additional 2 grams of 20% magnesium sulphate. Six percent cases required shifting to standard Pritchard regime, as they did not respond to low dose magnesium sulphate regime. The average total dose of magnesium sulphate required for control of convulsions was 20 grams ie. 54.4% less than that of standard Pritchard regime. The maternal and perinatal morbidity and mortality in the present study werecomparable to those of standard Pritchard regime. The study did not find a single case of magnesium related toxicity with low dose magnesium sulphate regime. Low dose magnesium sulphate regime was found to be safe and effective in eclampsia.
Low-dose methotrexate administration in the management of cervical pregnancy
Christine E. Reissmann,Tamme W. Goecke,Matthias W. Beckmann,Ralf L. Schild
Journal of the Turkish-German Gynecological Association , 2009,
Abstract: Objective: Cervical pregnancy is a rare form of ectopic pregnancy. There is the risk of hysterectomy when this type of ectopic pregnancy is managed with surgery. An established form of conservative treatment is the administration of methotrexate (MTX). We demonstrate the effectiveness of a low-dose MTX regimen. Materials and Methods: Case analysis of cervical pregnancies at a tertiary referral center at an University Hospital. Six patients presented with cervical or isthmocervical pregnancies. Low-dose of MTX was administered intravenously. Secondary surgical intervention was carried out when needed. The main outcome measures were to preserve childbearing capacity using conservative treatment partly followed by curettage for cervical pregnancyResults: Six patients received conservative treatment with MTX in a low-dose regimen. During the course of conservative treatment with MTX, three patients underwent curettage. One of these patients also received an intra-amniotic administration in addition to systemic administration of MTX. Conclusions: Systemic low-dose methotrexate treatment is an effective form of primary treatment, with a low rate of side effects.
Body friendly, safe and effective regimen of MgSO4 for eclampsia
Gautam S. Aher, Urmila Gavali
International Journal of Medical Research and Health Sciences , 2013,
Abstract: Pre-eclampsia and eclampsia are major health problems in developing countries. MgSO4 is the standard drug in the control of convulsions in eclampsia. Our study carried out at PDVVPF’s hospital is based on the low dose regimen than Pritchard, which is suitable for Indian women who are of smaller built thanwomen in western world. This prospective study included 50 eclampsia patients receiving low dose MgSO4 therapy. The loading dose of MgSO4 was 9gm. Following this 2.5 gm was given intramuscularly every 6 hourly for 24 hours after administration of the loading dose. Patients were monitored hourly by observing their respiratory rate, knee jerk and urine output. Out of 50, two patients required Pritchard regimen, rest completely recovered from eclampsia. The maternal and perinatal morbidity and mortality were comparable to those of the standard Pritchard regime. The study did not find a single case of magnesium related toxicity with low dose MgSO4 regime. Low dose magnesium sulphate regime was found to be safe and effective in eclampsia
Adenosine or Magnesium Sulphate as Adjuvants for Pectoral Nerves Block in Modified Radical Mastectomy: A Randomized Controlled Trial  [PDF]
Ezzeldin Saleh Ibrahim, Wesameldin Abdelrahman Sultan
Open Journal of Anesthesiology (OJAnes) , 2018, DOI: 10.4236/ojanes.2018.85017
Abstract: Introduction: Magnesium sulphate can prolong the effect of local anaesthetics. Adenosine has not been compared to other local anaesthetics adjuvants. In the present study we aimed to compare the effect of adding magnesium sulphate and adenosine to bupivacaine for pectoral nerves block. Patients and Methods: In this randomized controlled trial, 90 females scheduled for breast surgery were included. Patients were divided into three groups. Patients received general anaesthesia with pectoral nerves block. Group C, A, and M had bupivacaine only, bupivacaine + adenosine, and bupivaciane + magnesium sulphate respectively. Post-operative visual analogue score, block duration, post-operative morphine consumption, sedation score, and peri-operative haemodynamic changes were recorded. Results: Visual analog score was lower in Group M compared to other groups. Group A and M showed significant longer duration of the block. Group M showed significant longer duration of action than Group A (p = 0.034). The total peri-operative morphine used was higher in Group C (p < 0.05). Post-operative Ramsay sedation score was significantly lower in Group A during the first two hours post-operatively (p > 0.05). Conclusions: Local anaesthetic adjuvants such as adenosine or magnesium sulphate can improve pectoral nerves block characteristics. Magnesium sulphate has an advantage over adenosine by increasing the block duration.
Ultra-Low Power High Temperature and Radiation Hard Complementary Metal-Oxide-Semiconductor (CMOS) Silicon-on-Insulator (SOI) Voltage Reference
El Hafed Boufouss,Laurent A. Francis,Valeriya Kilchytska,Pierre Gérard,Pascal Simon,Denis Flandre
Sensors , 2013, DOI: 10.3390/s131217265
Abstract: This paper presents an ultra-low power CMOS voltage reference circuit which is robust under biomedical extreme conditions, such as high temperature and high total ionized dose (TID) radiation. To achieve such performances, the voltage reference is designed in a suitable 130 nm Silicon-on-Insulator (SOI) industrial technology and is optimized to work in the subthreshold regime of the transistors. The design simulations have been performed over the temperature range of -40–200 °C and for different process corners. Robustness to radiation was simulated using custom model parameters including TID effects, such as mobilities and threshold voltages degradation. The proposed circuit has been tested up to high total radiation dose, i.e., 1 Mrad (Si) performed at three different temperatures (room temperature, 100 °C and 200 °C). The maximum drift of the reference voltage V REF depends on the considered temperature and on radiation dose; however, it remains lower than 10% of the mean value of 1.5 V. The typical power dissipation at 2.5 V supply voltage is about 20 μW at room temperature and only 75 μ?W at a high temperature of 200 °C. To understand the effects caused by the combination of high total ionizing dose and temperature on such voltage reference, the threshold voltages of the used SOI MOSFETs were extracted under different conditions. The evolution of V REF and power consumption with temperature and radiation dose can then be explained in terms of the different balance between fixed oxide charge and interface states build-up. The total occupied area including pad-ring is less than 0.09 mm2.
Should Magnesium Sulphate Prophylaxis be Used in all Cases of Severe Preeclampsia?
Sohini Bhattacharya,,Animesh Naskar,,Sukanta Mondal,,Ajanta Samanta
Online Journal of Health & Allied Sciences , 2011,
Abstract: A case control study, undertaken in the department of Obstetrics and Gynecology in a tertiary referral centre, was designed to administer standard dose of magnesium sulphate to 50 randomly selected severely preeclamptic women in labor (Group 1). 48 women who formed the control group did not receive the drug (Group 2). The admission – delivery interval, rate of Cesarean section showed no statistically significant difference. Four patients developed convulsions in Group 1 in contrast to twelve patients in Group 2. Efficacy of magnesium sulphate at preventing eclampsia was calculated as 68%. Mild respiratory depression occurred in two cases and oliguria in eight cases in Group 1. Both the conditions improved on suspending further doses of magnesium sulphate. No patient had post partum haemorrhage in Group 1 although 4% patients had it in Group 2. Neonatal outcome was comparable in both the groups. Hence magnesium sulphate may be regarded as a fairly safe and effective prophylactic agent for eclampsia when used in severe preeclampsia in labor.
The Impact of Single Low Dose IV Magnesium Sulphate Adjuvant to Ultrasound Guided Transverses Abdominis Plain Block for Control of Postcesarean Pain  [PDF]
Tamer Nabil Abd Elrahman, Mohamed Abdelaziz Youssry
Open Journal of Obstetrics and Gynecology (OJOG) , 2017, DOI: 10.4236/ojog.2017.73029
Abstract: Objective: The aim of this study is to determine the role of preoperative low dose intravenous MgSO4 when given adjuvant to ultrasound guided transversus abdominis plane (TAP) block in augmenting postcesarean analgesic effects and reducing opioid requirements during the first 24 hours. Subjects and Methods: In this prospective, randomized double blind study, a total of sixty full term pregnant women were recruited for the study underwent caesarean section. Thirty patients were assigned to MgSO4 group (A) and another thirty to placebo group (B). Participants in group (A) received 50 mg/kg MgSO4 in 100 ml isotonic saline intravenous (IV) over 20 minutes prior to induction of general anesthesia by 30 minutes while participants in group (B) received 100 ml isotonic saline (placebo) by the same route and over the same duration as control. Results: Visual Analogue Scale (VAS) was analysed within 24 hours postoperatively. The mean pain score at 6 and 12 hours postoperatively was significantly lower in MgSO4 group compared to control group (40.4 ± 5.12 vs 53.6 ± 4.92; 26.1 ± 3.01 vs 35.5 ± 3.98 respectively, p = 0.012, 0.005). Comparing both groups regarding the mean time interval of first rescue analgesia (morphine sulphate) requested by the patients, it was longer in MgSO4 group compared to control group. The total dose of rescue analgesia consumed during 24 hours was analysed and it was significantly higher in control group compared to MgSO4 group (10.1 ± 0.95 vs 6.2 ± 0.87, p = 0.001). Conclusion: We concluded that preoperative low doses (50 mg/Kg) of MgSO4 with general anesthesia combined with ultrasound guided TAP block offer longer postoperative pain free periods thus reducing total opioid consumption. In addition to the safety of the drug to the mother and fetus so we recommend IV MgSO4 as an adjuvant therapy with TAP block.
Pilot Study: Magnesium Sulphate Administration and Early Resolution of Hypoxic Ischemic Encephalopathy in Severe Perinatal Asphyxia  [PDF]
Simon Pius, Mustapha Bello, Jose Pwavimbo Ambe, Yenti Machoko, Adama Yusuf Clement, Rhoda Genesis, Mark Inusa Kamas
Open Journal of Pediatrics (OJPed) , 2019, DOI: 10.4236/ojped.2019.91009
Abstract: Introduction: Perinatal asphyxia is one of the leading causes of perinatal death and a recognized cause of neuromotor disability among survivors. About 20% - 30% of asphyxiated newborns who develop hypoxic ischemic encephalopathy (HIE) die during the neonatal period, and one third to one half of survivors are left with cerebral palsy and mental retardation. Objective of the Study: Was to determine the effect of magnesium sulphate as neuroprotective drug in hypoxic ischemic encephalopathy resulting from severe perinatal asphyxia. Materials and Methods: A prospective administration of magnesium sulphate to 52 severely asphyxiated newborns with hypoxic ischemic encephalopathy was conducted over one year period from 1st August 2017 to 31st July 2018. Results: Most (96.2%) of patients were term baby (GA ≥ 37 weeks). Most (90.4%) were in-hospital born, vaginal delivery accounted for 55.8% and 44.2% assisted delivery respectively. About one half (55.8%) of the patients commenced MgSO4 therapy at <6 hours after birth, while 30.6% and 16.6% commenced MgSO4 therapy at 6 - <24 hours and >24 hours after birth respectively. Time of commencement of first enteral feeding (p =
Response of Maize to Magnesium and Zinc Application in the Semi Arid Zone of West Africa
A.A. Abunyewa,H. Mercer-Quarshie
Asian Journal of Plant Sciences , 2004,
Abstract: Zinc sulphate application significantly influenced maize grain yield in a three-year (1997-1999) trial investigating the effect of magnesium and zinc on maize production in the semi arid zone of West Africa. Three levels of Mg (0, 15 and 25 kg haG1) as magnesium sulphate (MgSO4) and three levels of Zn (0, 5 and 10 kg haG1) as zinc sulphate (ZnSO4) were applied to maize. The experimental design was split-plot with two levels of nitrogen (40 and 90 kg N haG1) as the main plot and Mg and Zn as subplots with six replications. Initial soil analysis indicated medium levels of Mg and low levels of Zn. Maize grain yield as a result of Mg application ranged from 1.3 to 2.8 t haG1 representing 0.6 to 16.5% increase during the 3 years, while grain yield due to zinc application ranged between 0.9 and 3.2 t haG1 representing 84 to 108% increase in the three-year period. Zinc and magnesium interaction was synergetic resulting in grain yield ranging between 0.97 and 2.2 t haG1, indication 27 to 150% increase over the control in the 3-year period. While ZnSO4 application resulted in significant increase in soil zinc level that of magnesium sulphate did not.
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