Total of 6 articles.
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May 19, 2023Open AccessArticle
We describe a planar MEMS silicon structure to record ion channel currents in biological cells. The conventional method of performing an electrophysiological experiment, 'patch-clamping', employs a glass micropipette. The micropipette tip is a source of thermal noise because of its inherent, tapered, conical structure, giving rise to a large pipette resistance. This pipette resistance, when coupled with the biological cell capacitance, limits the available bandwidth of single ion channel recordi...
Taxonomy
Microbiology
Biochemistry
Biodiversity
Developmental Biology
Bioengineering
Bioinformatics
Environmental Sciences
Agricultural Science
Computational Biology
Genetics
Cell Biology
Food Science & Technology
Parasitology
Synthetic Biology
May 19, 2023Open AccessArticle
Computer simulations of realistic ion channel structures have always been challenging and a subject of rigorous study. Simulations based on continuum electrostatics have proven to be computationally cheap and reasonably accurate in predicting a channel's behavior. In this paper we discuss the use of a device simulator, SILVACO, to build a solid-state model for KcsA channel and study its steady-state response. SILVACO is a well-established program, typically used by electrical engineers to simula...
Biological Chemistry
Photochemistry
Taxonomy
Medicinal Chemistry
Ecosystem Science
Developmental Biology
Computational Robotics
Complex network models
Artificial Intelligence
Genetics
Theoretical Chemistry
Analytical Chemistry
Neuroscience
Biological Materials
Nanometer Materials
Green Chemistry
Mathematical Biology
Molecular Biology
Microbiology
Biochemistry
Biodiversity
Bioengineering
Bioinformatics
Biophysics
Biotechnology
Functional Materials
Computational Biology
Synthetic Biology
May 19, 2023Open AccessArticle
Infections from parasitic nematodes (or roundworms) contribute to a significant disease burden and productivity losses for humans and livestock. The limited number of anthelmintics (or antinematode drugs) available today to treat these infections are rapidly losing their efficacy as multidrug resistance in parasites becomes a global health challenge. We propose an engineering approach to discover an anthelmintic drug combination that is more potent at killing wild-type Caenorhabditis elegans wor...
Neuroscience
Marine Biology
Toxicology
Taxonomy
Microbiology
Ecosystem Science
Biodiversity
Developmental Biology
Bioengineering
Environmental Sciences
Animal Behavior
Agricultural Science
Biotechnology
Computational Biology
Food Science & Technology
Parasitology
Plant Science
Synthetic Biology
May 19, 2023Open AccessArticle
All life forms use a seamless integration of physical and chemical sensing mechanisms to enhance their performance and survival skills. To mimic the integrative sensing abilities found in nature, there is a significant interest in developing wearable devices that can smartly track the physiological and biochemical signals of the human body. Progress in wearable physical sensors has been remarkable giving rise to a number of consumer electronics products meant to measure parameters related to act...
Electric Engineering
Green Chemistry
Electrochemistry
Biological Chemistry
Mathematical Biology
Biochemistry
Bioengineering
Bioinformatics
Fundamentals of Material Science
Biophysics
Environmental Sciences
Functional Materials
Chemical Engineering & Technology
Genomics
Computational Biology
Plant Science
Synthetic Biology
Materials Engineering
Analytical Chemistry
Nov 20, 2017Open AccessArticle
The complex biomechanics and morphology of the femur proximal epiphysis are presented. This specific region in human femur is characterized by a high flexibility compared to that of other primates, since evolved lighter and longer due to the human verticalposition and more balanced loading. The nature and fine morphology of the femur head and its structural behavior have been investigated. Isotropic and orthotropic trabecular structures, which are not present in other primates, have been associa...
Biological Materials
Public Health
Biological Chemistry
Anatomy & Physiology
Dentistry
Global Health
Biochemistry
Bioengineering
Biophysics
Biotechnology
Biological Engineering
Computational Biology
Cell Biology
Orthopedics
Synthetic Biology
Internal Medicine
Surgery & Surgical Specialties
Aug 15, 2016Open AccessArticle
The presence of three nitrogen hetero-atoms in five-membered ring systems defines an interesting class of compounds, the triazole. This may be of two types, the 1,2,3-triazoles and the 1,2,4-triazoles. Out of the two triazoles, 1,2,4-triazole have drawn great attention due to its wide variety of activities, low toxicities and good pharmacokinetic and pharmacodynamic profiles. Chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their effect...
Biological Materials
Biological Chemistry
Photochemistry
Biochemistry
Synthetic Biology
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