Computer simulations of realistic ion channel structures have always been challenging and a subject of rigorous study. Simulations based on continuum electrostatics have proven to be computationally cheap and reasonably accurate in predicting a channel's behavior. In this paper we discuss the use of a device simulator, SILVACO, to build a solid-state model for KcsA channel and study its steady-state response. SILVACO is a well-established program, typically used by electrical engineers to simula...

Biological Chemistry  Photochemistry  Taxonomy  Medicinal Chemistry  Ecosystem Science  Developmental Biology  Computational Robotics  Complex network models  Artificial Intelligence  Genetics  Theoretical Chemistry  Analytical Chemistry  Neuroscience  Biological Materials  Nanometer Materials  Green Chemistry  Mathematical Biology  Molecular Biology  Microbiology  Biochemistry  Biodiversity  Bioengineering  Bioinformatics  Biophysics  Biotechnology  Functional Materials  Computational Biology  Synthetic Biology 

Doi:10.1016/j.cmpb.2006.08.007

Infections from parasitic nematodes (or roundworms) contribute to a significant disease burden and productivity losses for humans and livestock. The limited number of anthelmintics (or antinematode drugs) available today to treat these infections are rapidly losing their efficacy as multidrug resistance in parasites becomes a global health challenge. We propose an engineering approach to discover an anthelmintic drug combination that is more potent at killing wild-type Caenorhabditis elegans wor...

Neuroscience  Marine Biology  Toxicology  Taxonomy  Microbiology  Ecosystem Science  Biodiversity  Developmental Biology  Bioengineering  Environmental Sciences  Animal Behavior  Agricultural Science  Biotechnology  Computational Biology  Food Science & Technology  Parasitology  Plant Science  Synthetic Biology 

Doi:10.1126/sciadv.aao1254

In the last few years, many research works have been suggested on Brain-Computer Interface (BCI), which assists severely physically disabled persons to communicate directly with the help of electroencephalogram (EEG) signal, generated by the thought process of the brain. Thought generation inside the brain is a dynamic process, and plenty thoughts occur within a small time window. Thus, there is a need for a BCI device that can distinguish these various ideas simultaneously. In this research wor...

Artificial Intelligence  Neuroscience  Computer Engineering 

Doi:10.1016/j.neucom.2018.07.094

Clinically, it has long been shown that the slow wave sleep(SWS) may adjust the emotional balance against depression. In this article, it is classified three types of regulations on emotional/autonomic nervous system by SWS. (1) In the initial stage of SWS, it is the lower ratio of respiratory inspiration/expiration that delivers the signal of tiredness, as the result of decrease in excitation from inspiratory motoneurons more than that from expiration in SWS. It is pointed out that this charact...

Neuroscience  Psychiatry & Psychology  Zoology  Anatomy & Physiology 

Doi:10.5350/Sleep.Hypn.2019.21.0189

The limbic-reticular coupling theory suggests that the hippocampus and amygdala regulate such descending limbic structures as the mammillary bodies, septum, hypothalamus and epithalamus to regulate the ascending noradrenergic, serotonergic, dopaminergic and cholinergic systems, performing declarative memory consolidation and recall. Recent studies have revealed that, less sensitive to familiarity, the hippocampus functions via the fornix, mammillary bodies and hypothalamus for memory recall. Les...

Neuroscience  Psychiatry & Psychology  Neurology 

Doi:10.1590/1980-57642018dn12-020002

In this perspective review, it is adopted the neurobiological interactions and conflicts of both perceived realities and acquired memories with the instinctual drives to represent such terms and interactions as unconscious/preconscious/conscious or id/ego/super-ego of the Freudian theories in psychoanalysis. During waking, it is demonstrated the interactions and conflicts of realities/memories with the instinctual drives are present in all vertebrates including humans. For the rapid eye movement...

Neuroscience  Psychiatry & Psychology 

Doi:-

The mitochondrion is a natural robot (cell) with a length of about one micron. Between organisms (plant, animal or human) with its organs and the atomic and molecular components are positioned based cells, which are building all the necessary organs body. Years ago, medical specialists who are studying organ disease have considered that is caused by impaired organ or related to other organs. For example, it was considered that all nerve diseases have started from stress due to disorder of the hy...

Neuroscience  Public Health  Biotechnology  Molecular Biology  Genetics  Microbiology  Cell Biology  Biochemistry  Bioengineering  Medical Genetics 

Doi:10.3844/ajeassp.2016.991.1002

With preliminary classification, there are five behavioral functions for rapid eye movement(REM) sleep after puberty, which are memory retention, drive dissipation, muscular efficiency, heat control and adaptive immobility. For these diversities, it is newly suggested in this mini-review to categorize the REM sleep into two types respectively as atonic and brain REM sleep. In concrete words, the atonic REM sleep was acquired early in platypus, ostrich, and reptiles, responsible for the adaptive ...

Neuroscience  Animal Behavior  Psychiatry & Psychology 

Doi:10.5350/Sleep.Hypn.2016.18.0113

Many observations have demonstrated that the hypothalamic neuroendocrine change determines the chronological sequence of aging in mammals. However, it remains uncertain on the mechanism to account for the hypothalamic aging manifestations. In this article, it is pointed out that, as constantly exposed to sunshine and oxygen, the skin would undergo both telomere-shortening and oxidative senescent processes. The senescent alterations of skin, such as attenuation in electrodermal activities, would ...

Neuroscience  Animal Behavior  Zoology  Developmental Biology 

Doi:10.1016/j.slsci.2016.09.004

Mammalian esophagus exhibits a remarkable change in epithelial structure during the tran- sition from embryo to adult. However, the molecular mechanisms of esophageal epithelial development are not well understood. Zebrafish (Danio rerio), a common model organism for vertebrate development and gene function, has not previously been characterized as a model system for esophageal epithelial development. In this study, we characterized a piece of non-keratinized stratified squamous epithelium ...

Neuroscience  Microbiology 

Doi:10.1371/journal.pone.0143878