Computer simulations of realistic ion channel structures have always been challenging and a subject of rigorous study. Simulations based on continuum electrostatics have proven to be computationally cheap and reasonably accurate in predicting a channel's behavior. In this paper we discuss the use of a device simulator, SILVACO, to build a solid-state model for KcsA channel and study its steady-state response. SILVACO is a well-established program, typically used by electrical engineers to simula...

Biological Chemistry  Photochemistry  Taxonomy  Medicinal Chemistry  Ecosystem Science  Developmental Biology  Computational Robotics  Complex network models  Artificial Intelligence  Genetics  Theoretical Chemistry  Analytical Chemistry  Neuroscience  Biological Materials  Nanometer Materials  Green Chemistry  Mathematical Biology  Molecular Biology  Microbiology  Biochemistry  Biodiversity  Bioengineering  Bioinformatics  Biophysics  Biotechnology  Functional Materials  Computational Biology  Synthetic Biology 

Doi:10.1016/j.cmpb.2006.08.007

Severe combined immunodeficiencies are a group of rare inherited disorders with profound defects in immune cells. This genetic disorder might have effect on T lymphocytes, B lymphocytes and/or Natural Killer cells (NK). This study aimed at the identifying the polymorphisms in ？nterleukin 7 reseptor gene present in severe combined immunodeficies patients who located in southern part of Turkey. A total of 30 patients with severe combined immunodeficiencies that were diagnosed both clinically and b...

Genomics  Molecular Biology  Genetics 

Doi:10.25279/sak.350281

The mitochondrion is a natural robot (cell) with a length of about one micron. Between organisms (plant, animal or human) with its organs and the atomic and molecular components are positioned based cells, which are building all the necessary organs body. Years ago, medical specialists who are studying organ disease have considered that is caused by impaired organ or related to other organs. For example, it was considered that all nerve diseases have started from stress due to disorder of the hy...

Neuroscience  Public Health  Biotechnology  Molecular Biology  Genetics  Microbiology  Cell Biology  Biochemistry  Bioengineering  Medical Genetics 

Doi:10.3844/ajeassp.2016.991.1002

The developed protocol describes a cheaper, quicker and reliable method for the isolation of pure DNA from medicinal herbs, such as Ammi majus, which produces the secondary metabolites xanthotoxin and berganpectane having immense medicinal importance. Use of CTAB, liquid nitrogen and EDTA in different isolation protocols analyzed for A. majus, all were ended with polysaccharide and protein contamination with low purity of DNA (A260/280 = 1.3 – 1.6), revealed a need for method modification for th...