We describe a planar MEMS silicon structure to record ion channel currents in biological cells. The conventional method of performing an electrophysiological experiment, 'patch-clamping', employs a glass micropipette. The micropipette tip is a source of thermal noise because of its inherent, tapered, conical structure, giving rise to a large pipette resistance. This pipette resistance, when coupled with the biological cell capacitance, limits the available bandwidth of single ion channel recordi...

Taxonomy  Microbiology  Biochemistry  Biodiversity  Developmental Biology  Bioengineering  Bioinformatics  Environmental Sciences  Agricultural Science  Computational Biology  Genetics  Cell Biology  Food Science & Technology  Parasitology  Synthetic Biology 

Doi:10.1016/j.sse.2004.05.072

Computer simulations of realistic ion channel structures have always been challenging and a subject of rigorous study. Simulations based on continuum electrostatics have proven to be computationally cheap and reasonably accurate in predicting a channel's behavior. In this paper we discuss the use of a device simulator, SILVACO, to build a solid-state model for KcsA channel and study its steady-state response. SILVACO is a well-established program, typically used by electrical engineers to simula...

Biological Chemistry  Photochemistry  Taxonomy  Medicinal Chemistry  Ecosystem Science  Developmental Biology  Computational Robotics  Complex network models  Artificial Intelligence  Genetics  Theoretical Chemistry  Analytical Chemistry  Neuroscience  Biological Materials  Nanometer Materials  Green Chemistry  Mathematical Biology  Molecular Biology  Microbiology  Biochemistry  Biodiversity  Bioengineering  Bioinformatics  Biophysics  Biotechnology  Functional Materials  Computational Biology  Synthetic Biology 

Doi:10.1016/j.cmpb.2006.08.007

Severe combined immunodeficiencies are a group of rare inherited disorders with profound defects in immune cells. This genetic disorder might have effect on T lymphocytes, B lymphocytes and/or Natural Killer cells (NK). This study aimed at the identifying the polymorphisms in ？nterleukin 7 reseptor gene present in severe combined immunodeficies patients who located in southern part of Turkey. A total of 30 patients with severe combined immunodeficiencies that were diagnosed both clinically and b...

Genomics  Molecular Biology  Genetics 

Doi:10.25279/sak.350281

The current study was carried out to investigate the impact of solid waste dumping sites on ground water quality in Jhang city, Pakistan. In order to investigate the solid waste disposal effects on ground water quality, the study area has been divided into two parts i.e solid waste sites and controlled area. Ground water is the major source of drinking water in study area. Therefore, water samples have been collected near and surrounding the municipal solid waste dumping sites and analyzed for v...

Agricultural Science  Genetics  Environmental Sciences 

Doi:-

The four basic elements of life are: Oxygen, hydrogen, nitrogen and phosphorus. These four elements are found in abundance in both the human body and in animals. There are other elements that compose the human body, but the four we've highlighted participate in all life processes. Besides, these four elements make up ATP chains (molecule), which governs and controls the body entirely energy processes and physiological and pathological processes of the human body. Oxygen is the pivot, which produ...

Biological Materials  Nanometer Materials  Genetic Engineering  Industrial Engineering  Biological Chemistry  High Polymer Chemistry  Inorganic Nonmetallic Materials  Civil Engineering  Geriatrics  Composite Material  Global Health  Structural Material  Biochemistry  Bioengineering  Fundamentals of Material Science  Biophysics  Biological Engineering  Biotechnology  Functional Materials  Chemical Engineering & Technology  Genetics  Cell Biology  Material Experiment 

Doi:10.3844/ajeassp.2016.1189.1197

Free radicals are natural nanoparticles which are doing their part well defined in the human cell, but then they must be annihilated or eliminated to not destroy the cell or another part of our body. It has been shown that residual free radicals in the body are responsible for the aging. The role to annihilate them is ful-filled by the antioxidants. Antioxidants are a group of compounds produced by the organism or that occur naturally in many foods. Antioxidants work together in the human body t...

Public Health  Biological Engineering  Biotechnology  Genetics  Health Policy  Geriatrics  Global Health  Biochemistry  Bioengineering  Internal Medicine  Medical Genetics 

Doi:10.3844/ajeassp.2016.1112.1126

The mitochondrion is a natural robot (cell) with a length of about one micron. Between organisms (plant, animal or human) with its organs and the atomic and molecular components are positioned based cells, which are building all the necessary organs body. Years ago, medical specialists who are studying organ disease have considered that is caused by impaired organ or related to other organs. For example, it was considered that all nerve diseases have started from stress due to disorder of the hy...

Neuroscience  Public Health  Biotechnology  Molecular Biology  Genetics  Microbiology  Cell Biology  Biochemistry  Bioengineering  Medical Genetics 

Doi:10.3844/ajeassp.2016.991.1002

Grewia asiatica L., is a species native to south Asia from Pakistan, east to Cambodia, cultivated primarily for its edible fruit and well-reputed for its diverse medicinal uses. Fruits are a rich source of nutrients such as proteins, amino acids, vitamins, and minerals and contain various bioactive compounds, like anthocyanins, tannins, phenolics and flavonoids. Different parts of this plant possess different pharmacological properties. Leaves have antimicrobial, anticancer, antiplatelet and ant...

Biological Chemistry  Cardiology  Toxicology  Photochemistry  Taxonomy  Medicinal Chemistry  Environmental Sciences  Agricultural Science  Genetics  Food Science & Technology  Nutrition  Analytical Chemistry  Biological Materials  Environmental Chemistry  Green Chemistry  Pharmacology  Public Health  Organic Chemistry  Evidence Based Medicine  Gastroenterology & Hepatology  Microbiology  Global Health  Biochemistry  Biodiversity  Biophysics  Biotechnology  Translational Medicine  Respiratory Medicine 

Doi:10.3390/molecules18032663