Total of 10 articles.


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May 19, 2023Open    AccessArticle

Unidirectional, electrotactic-response valve for Caenorhabditis elegans in microfluidic devices

Santosh Pandey
We report a nematode electrotactic-response valve (NERV) to control the locomotion of Caenorhabditis elegans (C. elegans) in microfluidic devices. This nonmechanical, unidirectional valve is based on creating a confined region of lateral electric field that is switchable and reversible. We observed that C. elegans do not prefer to pass through this region if the field lines are incident to its forward movement. Upon reaching the boundary of the NERV, the incident worms partially penetrate the fi...

Animal Behavior  Zoology  Mathematical Biology  Veterinary Medicine  Cell Biology  Parasitology  Developmental Biology  Evolutionary Studies  Bioengineering  Bioinformatics  Environmental Sciences  Biophysics 

May 19, 2023Open    AccessArticle

Simulation of biological ion channels with technology computer-aided design

Santosh Pandey, Bortei-Doku, A. White, M.H.
Computer simulations of realistic ion channel structures have always been challenging and a subject of rigorous study. Simulations based on continuum electrostatics have proven to be computationally cheap and reasonably accurate in predicting a channel's behavior. In this paper we discuss the use of a device simulator, SILVACO, to build a solid-state model for KcsA channel and study its steady-state response. SILVACO is a well-established program, typically used by electrical engineers to simula...

Biological Chemistry  Photochemistry  Taxonomy  Medicinal Chemistry  Ecosystem Science  Developmental Biology  Computational Robotics  Complex network models  Artificial Intelligence  Genetics  Theoretical Chemistry  Analytical Chemistry  Neuroscience  Biological Materials  Nanometer Materials  Green Chemistry  Mathematical Biology  Molecular Biology  Microbiology  Biochemistry  Biodiversity  Bioengineering  Bioinformatics  Biophysics  Biotechnology  Functional Materials  Computational Biology  Synthetic Biology 

May 19, 2023Open    AccessArticle

Flexible and disposable paper- and plastic based gel micropads for nematode handling, imaging, and chemical testing

Njus, Zach Kong, Taejoon Kalwa, Upender Legner, Christopher Weinstein, Matthew Flanigan, Shawn Saldanha, Jenifer Pandey, Santosh
In this paper, we explore the use of microfluidic paper-based analytical devices (?PADs) to study the behavior of Caenorhabditis elegans. We show how these devices can be fabricated on paper and plastic substrates, as well as how to load, visualize, and transfer single and multiple nematodes. We also demonstrate the use of anthelmintic drug, levamisole, to perform chemical testing on C. elegans. Furthermore, we provide a custom program that is able to recognize individual worms on the ?PADs in r...

Animal Behavior  Computational Biology  Microbiology  Cell Biology  Parasitology  Plant Science  Soil Science  Developmental Biology  Bioengineering  Environmental Sciences  Biophysics 

May 19, 2023Open    AccessArticle

Sweat sensing in the smart wearables era: Towards integrative, multifunctional and body-compliant perspiration analysis

Chris Legner, Upender Kalwa, Vishal Patel, Austin Chesmore, Santosh Pandey
All life forms use a seamless integration of physical and chemical sensing mechanisms to enhance their performance and survival skills. To mimic the integrative sensing abilities found in nature, there is a significant interest in developing wearable devices that can smartly track the physiological and biochemical signals of the human body. Progress in wearable physical sensors has been remarkable giving rise to a number of consumer electronics products meant to measure parameters related to act...

Electric Engineering  Green Chemistry  Electrochemistry  Biological Chemistry  Mathematical Biology  Biochemistry  Bioengineering  Bioinformatics  Fundamentals of Material Science  Biophysics  Environmental Sciences  Functional Materials  Chemical Engineering & Technology  Genomics  Computational Biology  Plant Science  Synthetic Biology  Materials Engineering  Analytical Chemistry 

Nov 20, 2017Open    AccessArticle

Flexible Stem Trabecular Prostheses

Raffaella Aversa, Florian Ion T. Petrescu, Relly Victoria V. Petrescu and Antonio Apicella
The complex biomechanics and morphology of the femur proximal epiphysis are presented. This specific region in human femur is characterized by a high flexibility compared to that of other primates, since evolved lighter and longer due to the human verticalposition and more balanced loading. The nature and fine morphology of the femur head and its structural behavior have been investigated. Isotropic and orthotropic trabecular structures, which are not present in other primates, have been associa...

Biological Materials  Public Health  Biological Chemistry  Anatomy & Physiology  Dentistry  Global Health  Biochemistry  Bioengineering  Biophysics  Biotechnology  Biological Engineering  Computational Biology  Cell Biology  Orthopedics  Synthetic Biology  Internal Medicine  Surgery & Surgical Specialties 

Nov 20, 2017Open    AccessArticle

The Basic Elements of Life's

Raffaella Aversa, Victoria Petrescu, Antonio Apicella and Ion Tiberiu Petrescu
The four basic elements of life are: Oxygen, hydrogen, nitrogen and phosphorus. These four elements are found in abundance in both the human body and in animals. There are other elements that compose the human body, but the four we've highlighted participate in all life processes. Besides, these four elements make up ATP chains (molecule), which governs and controls the body entirely energy processes and physiological and pathological processes of the human body. Oxygen is the pivot, which produ...

Biological Materials  Nanometer Materials  Genetic Engineering  Industrial Engineering  Biological Chemistry  High Polymer Chemistry  Inorganic Nonmetallic Materials  Civil Engineering  Geriatrics  Composite Material  Global Health  Structural Material  Biochemistry  Bioengineering  Fundamentals of Material Science  Biophysics  Biological Engineering  Biotechnology  Functional Materials  Chemical Engineering & Technology  Genetics  Cell Biology  Material Experiment 

Nov 20, 2017Open    AccessArticle

Hybrid Ceramo-Polymeric Nanocomposite for Biomimetic Scaffolds Design and Preparation

Raffaella Aversa, Relly Victoria V. Petrescu, Roberto Sorrentino, Florian Ion T. Petrescu and Antonio Apicella
Biomimetics, biomechanics and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability. Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico). An innovative biomimetics and biomechanics approach and new synthetic structure providing a microenvironment, whi...

Biological Materials  Nanometer Materials  Inorganic Chemistry  Computational Chemistry  Industrial Engineering  Biological Chemistry  High Polymer Chemistry  Civil Engineering  Organic Polymer Materials  Medicinal Chemistry  Composite Material  Aerospace Engineering  Structural Material  Biochemistry  Bioengineering  Military Engineering  Fundamentals of Material Science  Biophysics  Biological Engineering  Biotechnology  Functional Materials  Chemical Engineering & Technology  Material Experiment 

Nov 20, 2017Open    AccessArticle

Biomimetic and Evolutionary Design Driven Innovation in Sustainable Products Development

Raffaella Aversa, Relly Victoria V. Petrescu, Florian Ion T. Petrescu and Antonio Apicella
An innovative, design-driven, sustainable approach in conceiving, developing, producing, using new materials can be effective in strengthening the competiveness and success of creative industries linked to manufacturing (e.g., biomedical, architecture, automotive, art, crafts, supports for cultural items, decoration, fashion, furniture, lighting, interior design materials and products, jewels, luxury, media supports, publishing, sport and toys), adding value to products and processes also by 'im...

Biological Materials  Nanometer Materials  Biological Chemistry  High Polymer Chemistry  Composite Material  Structural Material  Biochemistry  Bioengineering  Physical Chemistry  Biophysics  Surface and Intersurface of Materials  Biotechnology  Functional Materials  Material Experiment  Theoretical Chemistry 

Jul 09, 2015Open    AccessArticle

Grewia asiatica L., a Food Plant with Multiple Uses

Zia-Ul-Haq, M.; Stankovi?, M.S.; Rizwan, K.; Feo, V.D.
Grewia asiatica L., is a species native to south Asia from Pakistan, east to Cambodia, cultivated primarily for its edible fruit and well-reputed for its diverse medicinal uses. Fruits are a rich source of nutrients such as proteins, amino acids, vitamins, and minerals and contain various bioactive compounds, like anthocyanins, tannins, phenolics and flavonoids. Different parts of this plant possess different pharmacological properties. Leaves have antimicrobial, anticancer, antiplatelet and ant...

Biological Chemistry  Cardiology  Toxicology  Photochemistry  Taxonomy  Medicinal Chemistry  Environmental Sciences  Agricultural Science  Genetics  Food Science & Technology  Nutrition  Analytical Chemistry  Biological Materials  Environmental Chemistry  Green Chemistry  Pharmacology  Public Health  Organic Chemistry  Evidence Based Medicine  Gastroenterology & Hepatology  Microbiology  Global Health  Biochemistry  Biodiversity  Biophysics  Biotechnology  Translational Medicine  Respiratory Medicine 

Jul 09, 2015Open    AccessArticle

Rubus Fruticosus L.: Constituents, Biological Activities and Health Related Uses

Rubus fruticosus L. is a shrub famous for its fruit called blackberry fruit or more commonly blackberry. The fruit has medicinal, cosmetic and nutritive value. It is a concentrated source of valuable nutrients, as well as bioactive constituents of therapeutic interest highlighting its importance as a functional food. Besides use as a fresh fruit, it is also used as ingredient in cooked dishes, salads and bakery products like jams, snacks, desserts, and fruit preserves. R. fruticosus contains vit...

Biological Materials  Diabetes & Endocrinology  Green Chemistry  Biological Chemistry  Evidence Based Medicine  Gastroenterology & Hepatology  Toxicology  Taxonomy  Clinical Trials  Biochemistry  Bioinformatics  Biophysics  Environmental Sciences  Agricultural Science  Food Science & Technology  Translational Medicine  Plant Science  Analytical Chemistry 

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