[1] | Xylourgidis N, Fornerod M (2009) Acting Out of Character: Regulatory Roles of Nuclear Pore Complex Proteins. Aging 17: 617–625.
|
[2] | K?hler A, Hurt E (2010) Gene regulation by nucleoporins and links to cancer. Mol Cell 38: 6–15.
|
[3] | Cordes VC, Reidenbach S, Rackwitz HR, Franke WW (1997) Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J Cell Biol 136: 515–529.
|
[4] | Frosst P, Guan T, Subauste C, Hahn K, Gerace L (2002) Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J Cell Biol 156: 617–630.
|
[5] | Krull S, Thyberg J, Bjorkroth B, Rackwitz HR, Cordes VC (2004) Nucleoporins as components of the nuclear pore complex core structure and tpr as the architectural element of the nuclear basket. Mol Cell Biol 15: 4261–4277.
|
[6] | Bangs P, Burke B, Powers C, Craig R, Purohit A, et al. (1998) Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export. J Cell Biol 143: 1801–1812.
|
[7] | Cordes VC, Hase ME, Müller L (1998) Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex. Exp Cell Res 245: 43–56.
|
[8] | Hase ME, Cordes VC (2003) Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Mol Cell Biol 14: 1923–1940.
|
[9] | Galy V, Gadal O, Fromont-Racine M, Romano A, Jacquier A, et al. (2004) Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell 116: 63–73.
|
[10] | Dieppois G, Iglesias N, Stutz F (2006) Cotranscriptional recruitment to the mRNA export receptor Mex67p contributes to nuclear pore anchoring of activated genes. Mol Cell Biol 26: 7858–7870.
|
[11] | Ben-Efraim I, Frosst PD, Gerace L (2009) Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr. BMC Cell Biol 10: 74.
|
[12] | Galy V, Olivo-Marin JC, Scherthan H, Doye V, Rascalou N, et al. (2000) Nuclear pore complexes in the organization of silent telomeric chromatin. Nature 403: 108–112.
|
[13] | Feuerbach F, Galy V, Trelles-Sticken E, Fromont-Racine M, Jacquier A, et al. (2002) Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat Cell Biol 4: 214–221.
|
[14] | Taddei A, Hediger F, Neumann FR, Bauer C, Gasser SM (2004) Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. EMBO J 23: 1301–1312.
|
[15] | Lee SH, Sterling H, Burlingame A, McCormick F (2008) Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev 22: 2926–2931.
|
[16] | Lince-Faria M, Maffini S, Orr B, Ding Y, Florindo C, et al. (2009) Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator. J Cell Biol 184: 647–657.
|
[17] | Nakano H, Funasaka T, Hashizume C, Wong RW (2010) Nucleoporin translocated promoter region Tpr associates with dynein complex, preventing chromosome lagging formation during mitosis. J Biol Chem 285: 10841–10849.
|
[18] | Vomastek T, Iwanicki MP, Burack WR, Tiwari D, Kumar D, et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol 28: 6954–6966.
|
[19] | Zhao X, Wu CY, Blobel G (2004) Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality. J Cell Biol 167: 605–611.
|
[20] | Palancade B, Liu X, Garcia-Rubio M, Aguilera A, Zhao X, et al. (2007) Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes. Mol Biol Cell 18: 2912–2923.
|
[21] | Jacob Y, Mongkolsiriwatana C, Veley KM, Kim SY, Michaels SD (2007) The nuclear pore protein AtTPR is required for RNA homeostasis, flowering time, and auxin signaling. Plant Physiol 144: 1383–1390.
|
[22] | Mukhopadhyay D, Dasso M (2007) Modification in reverse: the SUMO proteases. Trends Biochem Sci 32: 286–295.
|
[23] | Geiss-Friedlander R, Melchior F (2007) Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol 8: 947–956.
|
[24] | Palancade B, Doye V (2008) Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties? Trends Cell Biol 18: 174–183.
|
[25] | Hang J, Dasso M (2002) Association of the human SUMO-1 protease SENP2 with the nuclear pore. J Biol Chem 277: 19961–19966.
|
[26] | Zhang H, Saitoh H, Matunis MJ (2002) Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol Cell Biol 22: 6498–6508.
|
[27] | Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614–636.
|
[28] | Braig M, Schmitt CA (2006) Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res 66: 2881–2884.
|
[29] | Courtois-Cox S, Jones SL, Cichowski K (2008) Many roads lead to oncogene-induced senescence. Oncogene 27: 2801–2809.
|
[30] | Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92: 9363–9367.
|
[31] | Narita M, N?nez S, Heard E, Narita M, Lin AW, et al. (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113: 703–713.
|
[32] | Zhang R, Chen W, Adams PD (2003) Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 27: 2343–2358.
|
[33] | Walther TC, Alves A, Pickersgill H, Loiodice I, Hetzer M, et al. (2003) The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113: 195–206.
|
[34] | Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, et al. (1999) A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J 18: 1660–1672.
|
[35] | Meyer T, Begitt A, Vinkemeier U (2007) Green fluorescent protein-tagging reduces the nucleocytoplasmic shuttling specifically of unphosphorylated STAT1. FEBS J 274: 815–826.
|
[36] | Lee SH, Hannink M (2002) Characterization of the nuclear import and export functions of Ikappa B(epsilon). J Biol Chem 277: 23358–23366.
|
[37] | Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, et al. (2003) Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 22: 4212–4222.
|
[38] | Collado M, Serrano M (2006) The power and the promise of oncogene-induced senescence markers. Nature Reviews Cancer 6: 472–476.
|
[39] | Freedman DA, Levine AJ (1998) Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol Cell Biol 18: 7288–7293.
|
[40] | Wild T, Horvath P, Wyler E, Widmann B, Badertscher L, et al. (2010) A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. PLoS Biol 8: e1000522.
|
[41] | van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, et al. (2009) The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int J Cancer 124: 1829–1840.
|
[42] | Hietanen S, Lain S, Krausz E, Blattner C, Lane DP (2000) Activation of p53 in cervical carcinoma cells by small molecules. Proc Natl Acad Sci U S A 97: 8501–8506.
|
[43] | Lecane PS, Kiviharju TM, Sellers RG, Peehl DM (2003) Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line. Prostate 54: 258–267.
|
[44] | Inoue T, Wu L, Stuart J, Maki CG (2005) Control of p53 nuclear accumulation in stressed cells. FEBS Lett 579: 4978–4984.
|
[45] | Smart P, Lane EB, Lane DP, Midgley C, Vojtesek B, et al. (1999) Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. Oncogene 18: 7378–7386.
|
[46] | Daigle N, Beaudouin J, Hartnell L, Imreh G, Hallberg E, et al. (2001) Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. J Cell Biol 54: 71–84.
|
[47] | Rabut G, Doye V, Ellenberg J (2004) Mapping the dynamic organization of the nuclear pore complex inside single living cells. Nat Cell Biol 6: 1114–1121.
|
[48] | Itahana Y, Yeh ET, Zhang Y (2006) Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Mol Cell Biol 26: 4675–4689.
|
[49] | Rosas-Acosta G, Russell WK, Deyrieux A, Russell DH, Wilson VG (2005) A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. Mol Cell Proteomics 4: 56–72.
|
[50] | Vertegaal AC, Andersen JS, Ogg SC, Hay RT, Mann M, et al. (2006) Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics 5: 2298–2310.
|
[51] | Ayaydin F, Dasso M (2004) Distinct in vivo dynamics of vertebrate SUMO paralogues. Mol Biol Cell 15: 5208–5218.
|
[52] | Joseph J, Tan SH, Karpova TS, McNally JG, Dasso M (2002) SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. J Cell Biol 56: 595–602.
|
[53] | Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, et al. (2009) Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. Mol Cell 33: 570–580.
|
[54] | Li T, Santockyte R, Shen RF, Tekle E, Wang G, et al. (2006) Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J Biol Chem 281: 36221–36227.
|
[55] | Levenson VV, Davidovich IA, Roninson IB (2000) Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response. Cancer Res 60: 5027–5030.
|
[56] | Cortés R, Roselló-Lletí E, Rivera M, Martínez-Dolz L, Salvador A, et al. (2010) Influence of heart failure on nucleocytoplasmic transport in human cardiomyocytes. Cardiovasc Res 85: 464–472.
|
[57] | Evdokimov E, Sharma P, Lockett SJ, Lualdi M, Kuehn MR (2008) Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J Cell Sci 121: 4106–4113.
|
[58] | Pichler A, Melchior F (2002) Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport. Traffic 3: 381–387.
|
[59] | Makhnevych T, Sydorskyy Y, Xin X, Srikumar T, Vizeacoumar FJ, et al. (2009) Global map of SUMO function revealed by protein-protein interaction and genetic networks. Mol Cell 33: 124–135.
|
[60] | Li T, Evdokimov E, Shen RF, Chao CC, Tekle E, et al. (2004) Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. Proc Natl Acad Sci U S A 23: 8551–8556.
|
[61] | Bischof O, Dejean A (2007) SUMO is growing senescent. Cell Cycle 6: 677–681.
|
[62] | Yates KE, Korbel GA, Shtutman M, Roninson IB, DiMaio D (2008) Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell 7: 609–621.
|
[63] | Kuznetsov NV, Sandblad L, Hase ME, Hunziker A, Hergt M, et al. (2002) The evolutionarily conserved single-copy gene for murine Tpr encodes one prevalent isoform in somatic cells and lacks paralogs in higher eukaryotes. Chromosoma 111: 236–255.
|
[64] | Krull S, D?rries J, Boysen B, Reidenbach S, Magnius L, et al. (2010) Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion. EMBO J 29: 1659–1673.
|
[65] | Zhang XD, Goeres J, Zhang H, Yen TJ, Porter AC, et al. (2008) SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. Mol Cell 29: 729–741.
|
[66] | Yamamoto H, Ihara M, Matsuura Y, Kikuchi A (2003) Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. EMBO J 22: 2047–2059.
|
[67] | Meinecke I, Cinski A, Baier A, Peters MA, Dankbar B, et al. (2007) Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc Natl Acad Sci U S A 104: 5073–5078.
|
[68] | Yan J, Jiang J, Lim CA, Wu Q, Ng HH, et al. (2007) BLIMP1 regulates cell growth through repression of p53 transcription. Proc Natl Acad Sci U S A 104: 1841–1846.
|
[69] | Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U (2004) Nuclear export of microRNA precursors. Science 303: 95–98.
|