objective: helicobacter pylori (hp) gastric infection has been implicated as an important factor in occlusive arterial pathology. nowadays, it is suspected that central serous chorioretinopathy (csc) is due to a multifocal vascular occlusive disease of the choriocapillaris. the aim of this study was to determine the relation between gastric hp infection and csc. materials and methods: we evaluated a group of 16 patients with csc and 20 controls. hp infection was assessed by the 13c-urea breath test (ubt). clinical csc diagnosis was confirmed by fundus biomicroscopy and fluorescein angiography. results: out of 16 patients with csc, 11 (68.75%) were males and 5 (31.25%) females, with a mean age of 46.3 years. hp infection was positive in 11 patients (68.75%) and negative in 5 (31.25%). men were hp-positive (hp+) in 72.7% of cases, compared to women who were hp+ in 60% of cases. the difference in prevalence of hp between the csc-group (68.75%) and the control-group (30%) was found to be statistically significant (p< 0.05). hp+ patients had more gastric pain than hp negative (hp-) patients (72.73% vs 20%). conclusions: these results indicate a possible statistical association between helicobacter pylori gastric infection and csc. hp should thus be considered a risk factor in csc patients.