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Studies on the in Vitro Dissolution of Insoluble Volatile Drug from Su-Anxin Nasal Inhalant and Its Correlation on the Nose Steady Self-Controllable Expiration and Inspiration at Night

DOI: 10.4236/pp.2011.22008, PP. 67-72

Keywords: Su-Anxin Nasal Inhalants, Insoluble Volatile Drugs, Timing Drug Delivery System, In Vitro Dissolution, Controlled Release

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Abstract:

In the paper, the in vitro dissolution of borneol in 12 hours from 6 batches of optimized inhalant samples were investigated. As a new dosage form, the in vitro release apparatus of nasal inhalant was invented and a pushing bump was used according to the simulation of the nose expiration and inspiration. Based on the data of r2 in the profile and similar factor f2 from 6 linear release tendencies, a good controlled release and a zero order tendency were observed. It can be suggested that there is a good correlation between the in vitro controlled release and the nose steady self-controllable expiration and inspiration, which will contribute to the trend of insoluble volatile drug controlled release and the effect of quick absorption in nasal pulmonary delivery to cure severe or acute cardiovascular or lung diseases at patients' sleeping, such as angina or breathing obstruction. Also, it was concluded that the prescription composed of insoluble volatile drugs can be prepared to be nasal inhalant from which drugs can be absorbed through nose steady self-controllable inspiration to the lung then into the blood and have a great effectiveness improvement of bioavailability at night timing drug delivery system.

References

[1]  M. Shakeel, A. Trinidade, S. Jehan and K. W. Ah-See, “The Use of Complementary and Alternative Medicine by Patients Attending a General Otolaryngology Clinic: Can We Afford to Ignore It?” American Journal of Otolaryngology, Vol. 31, No. 4, 2010, pp. 252-260. doi:10.1016/j.amjoto.2009.02.016
[2]  K. J. Hunt, H. F. Coelho, B. Wider, R. Perry, S. K. Hung, R. Terry and E. Ernst, “Complementary and Alternative Medicine Use in England: Results from a National Survey.” International Journal of Clinical Practice, Vol. 64, No. 11, 2010, pp. 1496-1502. doi:10.1111/j.1742-1241.2010.02484.x
[3]  D. Jimbo, Y. Kimura, M. Taniguchi, M. Inoue and K. Urakami, “Effect of Aromatherapy on Patients with Alzheimer’s Disease.” Psychogeriatrics, Vol. 9, No. 4, 2009, pp. 173-179. doi:10.1111/j.1479-8301.2009.00299.x
[4]  L. Weinberg , D. Story , J. Nam and L. Mcnicol, “Pharmacoeconomics of Volatile Inhalational Anaesthetic Agents: An 11-Year Retrospective Analysis.” Anaesthesia and intensive care, Vol. 38, No. 5, 2010, pp. 849-854.
[5]  D. K. Conn and D. P. Seitz, “Advances in the Treatment of Psychi- Atric Disorders in Long-Term Care Homes.” Current Opinion in Psychiatry, Vol. 23, No. 6, 2010, pp. 516-521. doi:10.1097/YCO.0b013e32833efe56
[6]  E. Heuberger and J. Llmberger, “The Influence of Essential Oils on Human Vigilance.” Natural Product Communications, Vol. 5, No. 9, 2010, pp. 1441- 1446.
[7]  L. Moss , M. Rouse , K. A. Wesnes and M. Moss, “Differential Effects of the Aromas of Salvia Species on Memory and Mood.” Human Psychopharmacology, Vol. 25, No. 5, 2010, pp. 388-396. doi:10.1002/hup.1129
[8]  H. W. Tsang and T. Y. Ho, “A Systematic Review on the Anxiolytic Effects of Aromatherapy on Rodents under Experimentally Induced Anxiety Models.” Reviews in the Neurosciences, Vol. 21, No. 2, 2010, pp. 141-152.
[9]  M. H. Hur, M. S. Lee , C. Kim and E. Ernst, “Aromatherapy for Treatment of Hypertension: A Systematic Review.” Journal of Evaluation in Clinical Practice, Vol. 17, No. 2, 2010, pp. 1365-2753.
[10]  J. Tillett and D. Ames, “The Uses of Aromatherapy in Women’S Health.” Journal of Perinatal & Neonatal Nursing, Vol. 24, No. 3, 2010, pp. 238-245.
[11]  A. Supoken, T. Chaisrisawatsuk and B. Chumworathayi, “Proportion of Gynecologic Cancer Patients Using Complementary and Alternative Medicine.” Asian Pacific Journal of Cancer Prevention, Vol. 10, 2009, pp. 779-782.
[12]  X. D. Li and L. P. Zhang, “The Application Prospect of Nasal Inhalant of Traditional Chinese Medicine.” Journal of Fujian College of Traditional Chinese Medicine, 17, 2007, pp. 56-58.
[13]  S. T. Charlton, S. S. Davis and L. Illum, “Evaluation of Bioadhesive Polymer as Delivery Systems for Nose to Brain Delivery: In Vitro Characterisation Studies.” Journal of Controlled Release, Vol. 118, No. 2, 2007, pp. 225-234. doi:10.1016/j.jconrel.2006.12.014
[14]  R. Siekmeier and G. Scheuch, “Inhaled Insulin---Does It Become Reality?” Journal of Physiology and Pharmacology, Vol. 59, No. 6, 2008, pp. 81-113.
[15]  B. Luppi, F. Bigucci, T. Cerchiara and V. Zecchi, “Chitosan- Based Hydrogels for Nasal Drug Delivery: From Inserts to Nanoparticles.” Expert Opinion on Drug Delivery, Vol. 7, No. 7, 2010, pp. 811-828. doi:10.1517/17425247.2010.495981
[16]  K. W. Spencer, “Isopropyl Alcohol Inhalation as Treatment for Nausea and Vomiting.” Plastic Surgical Nurses, Vol. 24, No. 4, 2004, pp. 149- 154.
[17]  C. Li, C. S. Gao and X. G. Mei, “The Research Development of Protain/Polypeptide Drugs in Pulmonary Inhaled Preparation.” Foreign Medical Sciences Section of Pharmacy, Vol. 34, 2007, pp. 56-58.
[18]  J. P. Zhu and R. S. Zhao, “Inhaled Delivery Drugs and Their Clinical Application and Evaluation.” Clinical Medication Journal, Vol. 6, 2008, pp. 49-52.
[19]  Y. C. Hong and H. W. Huang, “To Cure Chronic Rhinitis Through a Main Drug Delivery: Chinese Medicine Aerosol.” Journal of Modern Integrated Medicine, Vol. 11, 2002, p. 1097
[20]  Q. L. Yang, “The Treatment of Respiratory Diseases: Chinese Medicine Aerosol.” Journal of Liaoning University of Traditional Chinese Medicine, Vol. 10, 2008, pp. 103-104.
[21]  L. Illum, “Nasal Drug Delivery---Possibilities, Problems and Solutions.” Journal of Controlled Release, Vol. 87, No. 1-3, 2003, pp. 187-198. doi:10.1016/S0168-3659(02)00363-2
[22]  X. D. Li and S. Y. Li, “Studies on Improving Absorption of Insoluble Volatile Drugs from Su-Anxin Nasal Inhalant,” The Proceedings of 2010 Second Asia Arden Pharmaceu- Tical Technology Forum, 279.
[23]  X. D. Li, Y. Chen and F. H. Wu, “Analysis of in Vitro And in Vivo Drug Components in Rabbits from Su- Anxin Nasal Inhalant.” Journal of Chengdu Medical College, Vol. 5, No. 2, 2010, pp. 119-121.
[24]  P. Costa, “An Alternative Method to the Evaluation of Similarity Factor in Dissolution Testing.” International Journal of Pharmaceutics, Vol. 220, No. 2, 2001, pp. 77-83. doi:10.1016/S0378-5173(01)00651-2

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