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Prevalência da doen?a do refluxo gastroesofágico em pacientes com fibrose pulmonar idiopática

DOI: 10.1590/S1806-37132009001200004

Keywords: pulmonary fibrosis, gastroesophageal reflux, prevalence, manometry, esophageal ph monitoring.

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Abstract:

objective: to determine the prevalence of gastroesophageal reflux disease (gerd) and to evaluate its clinical presentation, as well as the esophageal function profile in patients with idiopathic pulmonary fibrosis (ipf). methods: in this prospective study, 28 consecutive patients with ipf underwent stationary esophageal manometry, 24-h esophageal ph-metry and pulmonary function tests. all patients also completed a symptom and quality of life in gerd questionnaire. results: in the study sample, the prevalence of gerd was 35.7%. the patients were then divided into two groups: gerd+ (abnormal ph-metry; n = 10) and gerd- (normal ph-metry; n = 18). in the gerd+ group, 77.7% of the patients presented at least one typical gerd symptom. the ph-metry results showed that 8 (80%) of the gerd+ group patients had abnormal supine reflux, and that the reflux was exclusively in the supine position in 5 (50%). in the gerd+ and gerd- groups, respectively, 5 (50.0%) and 7 (38.8%) of the patients presented a hypotensive lower esophageal sphincter, 7 (70.0%) and 10 (55.5%), respectively, presenting lower esophageal dysmotility. there were no significant differences between the groups regarding demographic characteristics, pulmonary function, clinical presentation or manometric findings. conclusions: the prevalence of gerd in the patients with ipf was high. however, the clinical and functional characteristics did not differ between the patients with gerd and those without.

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