In order to solve the urgent problem of how to manage and sustain highway tunnels with advanced information technology with the background of the rapid development in the modern traffic, and achieve the cost-effectiveness optimal principle objectives under the premise of guaranteeing a smooth flow of traffic; a highway tunnel maintenance and management system framework and the key modules were proposed. First, the determined highway tunnel condition assessment index system was established according to the result of expert consulting forms. Secondly, the tunnel diseases, the corresponding maintenance measurements, and many-to-many relationship between diseases and maintenance measurements were introduced. Then, three kinds of 0-1 integer programming models were built according to different tunnel operators’ needs in the optimization decision module. Finally, the further development and implementation of the system was prospected. The research results can provide references to tunnel researchers and managers.