[1] | Van Den Berg DJ, Sharma AK, Bruno E, Hoffman R (1998) Role of members of the wnt gene family in human hematopoiesis. Blood 92: 3189-3202. PubMed: 9787155.
|
[2] | Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D et al. (1996) Functional interaction of [beta]-catenin with the transcription factor LEF-1. Nature 382: 638-642. doi:10.1038/382638a0. PubMed: 8757136.
|
[3] | Huelsken J, Vogel R, Brinkmann V, Erdmann B, Birchmeier C et al. (2000) Requirement for β-catenin in anterior-posterior axis formation in mice. J Cell Biol 148: 567-578. doi:10.1083/jcb.148.3.567. PubMed: 10662781.
|
[4] | Ysebaert L, Chicanne G, Demur C, De Toni F, Prade-Houdellier N et al. (2006) Expression of [beta]-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia 20: 1211-1216. doi:10.1038/sj.leu.2404239. PubMed: 16688229.
|
[5] | Clements WK, Kim AD, Ong KG, Moore JC, Lawson ND et al. (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature 474: 220-224. doi:10.1038/nature10107. PubMed: 21654806.
|
[6] | de Andrés B, Gonzalo P, Minguet S, Martínez-Marin JA, Soro PG et al. (2002) The first 3 days of B-cell development in the mouse embryo. Blood 100: 4074-4081. doi:10.1182/blood-2002-03-0809. PubMed: 12393735.
|
[7] | Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W (1997) A role for the wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells. Blood 89: 3624-3635. PubMed: 9160667.
|
[8] | Corrigan PM, Dobbin E, Freeburn RW, Wheadon H (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells Dev 18: 759-772. doi:10.1089/scd.2008.0270. PubMed: 18800919.
|
[9] | Tran HT, Sekkali B, Van Imschoot G, Janssens S, Vleminckx K (2010) Wnt/β-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo. Proceedings of the National Academy of Sciences of the USA 107: 16160-16165. doi:10.1073/pnas.1007725107.
|
[10] | Lacaud G, Robertson S, Palis J, Kennedy M, Keller G (2001) Regulation of hemangioblast development. Ann N Y Acad Sci 938: 96-108. PubMed: 11458531.
|
[11] | Ema H, Nakauchi H (2000) Expansion of hematopoietic stem cells in the developing liver of a mouse embryo. Blood 95: 2284-2288. PubMed: 10733497.
|
[12] | Takada S, Stark KL, Shea MJ, Vassileva G, McMahon JA et al. (1994) Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev 8: 174-189. doi:10.1101/gad.8.2.174. PubMed: 8299937.
|
[13] | Luis TC, Weerkamp F, Naber BAE, Baert MRM, de Haas EFE et al. (2009) Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation. Blood 113: 546-554. doi:10.1182/blood-2008-06-163774. PubMed: 18832654.
|
[14] | Ruiz-Herguido C, Guiu J, D'Altri T, Inglés-Esteve J, Dzierzak E et al. (2012) Hematopoietic stem cell development requires transient wnt/β-catenin activity. J Exp Med, 209: 1457–68. PubMed: 22802352 .
|
[15] | Reya T, Duncan AW, Ailles L, Domen J, Scherer DC et al. (2003) A role for wnt signalling in self-renewal of haematopoietic stem cells. Nature 423: 409-414. doi:10.1038/nature01593. PubMed: 12717450.
|
[16] | Zhao C, Blum J, Chen A, Kwon HY, Jung SH et al. (2007) Loss of β-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 12: 528-541. doi:10.1016/j.ccr.2007.11.003. PubMed: 18068630.
|
[17] | Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM et al. (2008) Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2: 274-283. doi:10.1016/j.stem.2008.01.003. PubMed: 18371452.
|
[18] | Cobas M, Wilson A, Ernst B, Mancini SJC, MacDonald HR et al. (2004) ?-Catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med 199: 221-229. doi:10.1084/jem.20031615. PubMed: 14718516.
|
[19] | Jeannet G, Scheller M, Scarpellino L, Duboux S, Gardiol N et al. (2008) Long-term, multilineage hematopoiesis occurs in the combined absence of β-catenin and γ-catenin. Blood 111: 142-149. doi:10.1182/blood-2007-07-102558. PubMed: 17906078.
|
[20] | Koch U, Wilson A, Cobas M, Kemler R, MacDonald HR et al. (2008) Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis. Blood 111: 160-164. doi:10.1182/blood-2007-07-099754. PubMed: 17855627.
|
[21] | Kirstetter P, Anderson K, Porse BT, Jacobsen SEW, Nerlov C (2006) Activation of the canonical wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7: 1048-1056. doi:10.1038/ni1381. PubMed: 16951689.
|
[22] | Scheller M, Huelsken J, Rosenbauer F, Taketo MM, Birchmeier W et al. (2006) Hematopoietic stem cell and multilineage defects generated by constitutive [beta]-catenin activation. Nat Immunol 7: 1037-1047. doi:10.1038/ni1387. PubMed: 16951686.
|
[23] | Baba Y, Garrett KP, Kincade PW (2005) Constitutively active 2-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors. Immunity 23: 599-609. doi:10.1016/j.immuni.2005.10.009. PubMed: 16356858.
|
[24] | Malhotra S, Baba Y, Garrett KP, Staal FJT, Gerstein R et al. (2008) Contrasting responses of lymphoid progenitors to canonical and noncanonical wnt signals. Journal of Immunology 181: 3955-3964. PubMed: 18768850.
|
[25] | Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL et al. (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423: 448-452. doi:10.1038/nature01611. PubMed: 12717451.
|
[26] | Luis TC, Naber BE, Roozen PC, Brugman MH, de?Haas EE et al. (2011) Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell 9: 345-356. doi:10.1016/j.stem.2011.07.017. PubMed: 21982234.
|
[27] | Gordon MK (1995) In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 7: 862-869. doi:10.1016/0955-0674(95)80071-9. PubMed: 8608017.
|
[28] | Keller G, Kennedy M, Papayannopoulou T, Wiles MV (1993) Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 13: 473-486. PubMed: 8417345.
|
[29] | Wiles MV, Keller G (1991) Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111: 259-267. PubMed: 1893864.
|
[30] | Smith AG (2001) Embryo derived stem cells: Of mice and men. Annu Rev Cell Dev Biol 17: 435-462. doi:10.1146/annurev.cellbio.17.1.435. PubMed: 11687496.
|
[31] | Keller G, Lacaud G, Robertson S (1999) Development of the hematopoietic system in the mouse. Exp Hematol 27: 777-787. doi:10.1016/S0301-472X(99)00024-7. PubMed: 10340392.
|
[32] | Dzierzak E (2003) Ontogenic emergence of definitive hematopoietic stem cells. Curr Opin Hematol 10: 229-234. doi:10.1097/00062752-200305000-00006. PubMed: 12690291.
|
[33] | Kennedy M, D'Souza SL, Lynch-Kattman M, Schwantz S, Keller G (2007) Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 109: 2679-2687. PubMed: 17148580.
|
[34] | Fehling HJ, Lacaud G, Kubo A, Kennedy M, Robertson S et al. (2003) Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation. Development 130: 4217-4227. doi:10.1242/dev.00589. PubMed: 12874139.
|
[35] | Nostro MC, Cheng X, Keller GM, Gadue P (2008) Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell 2: 60-71. doi:10.1016/j.stem.2007.10.011. PubMed: 18371422.
|
[36] | Cheng X, Huber TL, Chen VC, Gadue P, Keller GM (2008) Numb mediates the interaction between wnt and notch to modulate primitive erythropoietic specification from the hemangioblast. Development 135: 3447-3458. doi:10.1242/dev.025916. PubMed: 18799543.
|
[37] | Lengerke C, Schmitt S, Bowman TV, Jang IH, Maouche-Chretien L et al. (2008) BMP and wnt specify hematopoietic fate by activation of the cdx-hox pathway. Cell Stem Cell 2: 72-82. doi:10.1016/j.stem.2007.10.022. PubMed: 18371423.
|
[38] | Dobbin E, Corrigan PM, Walsh CP, Welham MJ, Freeburn RW et al. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leuk Res 32: 1554-1564. doi:10.1016/j.leukres.2008.02.007. PubMed: 18355917.
|
[39] | Huang C, Qin D (2010) Role of Lef1 in sustaining self-renewal in mouse embryonic stem cells. J Genet Genomics 37: 441-449. doi:10.1016/S1673-8527(09)60063-1. PubMed: 20659708.
|
[40] | Yuen D, Mittal L, Deng CX, Choi K (1998) Generation of a primitive erythroid cell line and promotion of its growth by basic fibroblast growth factor. Blood 91: 3202-3209. PubMed: 9558375.
|
[41] | Baik J, Borges L, Magli A, Thatava T, Perlingeiro RCR (2012) Effect of endoglin overexpression during embryoid body development. Exp Hematol 40: 837-846. doi:10.1016/j.exphem.2012.06.007. PubMed: 22728030.
|
[42] | Akashi K, Traver D, Miyamoto T, Weissman IL (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197. doi:10.1038/35004599. PubMed: 10724173.
|
[43] | Barth AIM, Pollack AL, Altschuler Y, Mostov KE, Nelson WJ (1997) NH2-terminal deletion of β-catenin results in stable colocalization of mutant β-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J Cell Biol 136: 693-706. doi:10.1083/jcb.136.3.693. PubMed: 9024698.
|
[44] | Paling NRD, Wheadon H, Bone HK, Welham MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279: 48063-48070. doi:10.1074/jbc.M406467200. PubMed: 15328362.
|
[45] | Arnold SJ, Stappert J, Bauer A, Kispert A, Herrmann BG et al. (2000) Brachyury is a target gene of the wnt/β-catenin signaling pathway. Mech Dev 91: 249-258. doi:10.1016/S0925-4773(99)00309-3. PubMed: 10704849.
|
[46] | Suzuki A, Raya á, Kawakami Y, Morita M, Matsui T et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proceedings of the National Academy of Sciences of the USA 103: 10294-10299. doi:10.1073/pnas.0506945103. PubMed: 16801560.
|
[47] | Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G (1998) A common precursor for hematopoietic and endothelial cells. Development 125: 725-732. PubMed: 9435292.
|
[48] | Singla DK, Schneider DJ, LeWinter MM, Sobel BE (2006) wnt3a but not wnt11 supports self-renewal of embryonic stem cells. Biochem Biophys Res Commun 345: 789-795. doi:10.1016/j.bbrc.2006.04.125. PubMed: 16707109.
|
[49] | Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10: 55-63. doi:10.1038/nm979. PubMed: 14702635.
|
[50] | Takao Y, Yokota T, Koide H (2007) β-Catenin up-regulates nanog expression through interaction with oct-3/4 in embryonic stem cells. Biochem Biophys Res Commun 353: 699-705. doi:10.1016/j.bbrc.2006.12.072. PubMed: 17196549.
|
[51] | Russ AP, Wattler S, Colledge WH, Aparicio SAJR, Carlton MBL et al. (2000) Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature 404: 95-99. doi:10.1038/35003601. PubMed: 10716450.
|
[52] | Wardle FC, Papaioannou VE (2008) Teasing out T-box targets in early mesoderm. Curr Opin Genet Dev 18: 418-425. doi:10.1016/j.gde.2008.07.017. PubMed: 18778771.
|
[53] | Boulet AM, Moon AM, Arenkiel BR, Capecchi MR (2004) The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol 273: 361-372. doi:10.1016/j.ydbio.2004.06.012. PubMed: 15328019.
|
[54] | Rojas A, De Val S, Heidt AB, Xu SM, Bristow J et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and. Development 132: 3405-3417. doi:10.1242/dev.01913. PubMed: 15987774.
|
[55] | Morrisey EE, Ip HS, Lu MM, Parmacek MS (1996) GATA-6: A zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 177: 309-322. doi:10.1006/dbio.1996.0165. PubMed: 8660897.
|
[56] | Saijoh Y, Adachi H, Mochida K, Ohishi S, Hirao A et al. (1999) Distinct transcriptional regulatory mechanisms underlie left–right asymmetric expression of lefty-1 and lefty-2. Genes and Development 13: 259-269. doi:10.1101/gad.13.3.259.
|
[57] | Anton R, Kestler HA, Kühl M (2007) β-Catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells. FEBS Lett 581: 5247-5254. doi:10.1016/j.febslet.2007.10.012. PubMed: 17950287.
|
[58] | Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T et al. (2006) Maintenance of embryonic stem cell pluripotency by nanog-mediated reversal of mesoderm specification. Nat Clin Pract Cardiovasc Med, 3 Suppl 1: S114–22. PubMed: 16501617.
|
[59] | ten Berge D, Kurek D, Blauwkamp T, Koole W, Maas A et al. (2011) Embryonic stem cells require wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol 13: 1070-1075. doi:10.1038/ncb2314. PubMed: 21841791.
|
[60] | Luis TC, Staal FJT (2009) WNT proteins: Environmental factors regulating HSC fate in the niche. Ann N Y Acad Sci 1176: 70-76. doi:10.1111/j.1749-6632.2009.04566.x. PubMed: 19796234.
|
[61] | Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M et al. (2006) Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo. Blood 108: 4018-4024. doi:10.1182/blood-2006-03-012872. PubMed: 16926294.
|
[62] | Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH (1997) A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 16: 3965-3973. doi:10.1093/emboj/16.13.3965. PubMed: 9233806.
|
[63] | Warren AJ, Colledge WH, Carlton MBL, Evans MJ, Smith AJH et al. (1994) The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development. Cell 78: 45-57. doi:10.1016/0092-8674(94)90571-1. PubMed: 8033210.
|
[64] | Yamada Y, Warren AJ, Dobson C, Forster A, Pannell R et al. (1998) The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proceedings of the National Academy of Sciences of the USA 95: 3890-3895. doi:10.1073/pnas.95.7.3890.
|
[65] | Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC et al. (2011) Lineage regulators direct BMP and wnt pathways to cell-specific programs during differentiation and regeneration. Cell 147: 577-589. doi:10.1016/j.cell.2011.09.044. PubMed: 22036566.
|
[66] | Wadman IA, Osada H, Grütz GG, Agulnick AD, Westphal H et al. (1997) The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 16: 3145-3157. doi:10.1093/emboj/16.11.3145. PubMed: 9214632.
|
[67] | Crispino JD, Lodish MB, MacKay JP, Orkin SH (1999) Use of altered specificity mutants to probe a specific ProteinProtein interaction in differentiation: The GATA-1:FOG complex. Mol Cell 3: 219-228. doi:10.1016/S1097-2765(00)80312-3. PubMed: 10078204.
|
[68] | Shimizu R, Takahashi S, Ohneda K, Engel JD, Yamamoto M (2001) In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis. EMBO J 20: 5250-5260. doi:10.1093/emboj/20.18.5250. PubMed: 11566888.
|
[69] | Kingsley PD, Malik J, Fantauzzo KA, Palis J. (2004) Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis. Blood 104: 19-25.
|
[70] | Robertson SM, Kennedy M, Shannon JM, Keller G (2000) A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1. Development 127: 2447-2459. PubMed: 10804185.
|
[71] | Nielsen PJ, Lorenz B, Müller AM, Wenger RH, Brombacher F et al. (1997) Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood 89: 1058-1067. PubMed: 9028339.
|
[72] | Mikkola HKA, Orkin SH (2006) The journey of developing hematopoietic stem cells. Development 133: 3733-3744. doi:10.1242/dev.02568. PubMed: 16968814.
|
[73] | Tanaka TS, Kunath T, Kimber WL, Jaradat SA, Stagg CA et al. (2002) Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. Genome Res 12: 1921-1928. doi:10.1101/gr.670002. PubMed: 12466296.
|
[74] | Tanaka Y, Joshi A, Wilson NK, Kinston S, Nishikawa S et al. (2012) The transcriptional programme controlled by Runx1 during early embryonic blood development. Dev Biol 366: 404-419. doi:10.1016/j.ydbio.2012.03.024. PubMed: 22554697.
|
[75] | Mikkola HKA, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH (2003) Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101: 508-516. doi:10.1182/blood-2002-06-1699. PubMed: 12393529.
|