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COMPARATIVE STUDY OF ANTHELMINTIC ACTIVITY BETWEEN ACETONE AND ETHANOLIC STEM BARK EXTRACTS OF SPONDIAS PINNATA (LINN.F) KURZ

Keywords: Spondias Pinnata , Anthelmintic activity , Ethanol extract , Acetone extract , Pheretima postuma.

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Abstract:

Spondias Pinnata (Linn.F) Kurz is found in tribal area of Mayurbhanj district and extensively used traditionally by the tribal people as Anthelmintic, Anti-inflammatory, Regulate menstruation, Anti-pyretic, Anti-tumor and Anti-bacterial activity1-6. The present study is attempted to explore the anthelmintic activity of acetone and ethanol extract of bark of plant Spondias Pinnata in a comparative study. The various doses of acetone and ethanol extracts were evaluated for their anthelmintic activities on adult Indian earthworms, Pheretima postuma. All extracts of both the solvents were able to show anthelmintic activity at (10, 25, 50 and 100 mg/ml) concentration. The activities are well comparable with standard drugs, Piperazine citrate and Albendazole (10 mg/ml).All the doses of acetone and ethanol extract of Spondias Pinnata showed better anthelmintic activities than the standard drugs. When the dose of extract is increased, a gradual increase in anthelmintic activity was observed. Ethanol extract showed better anthelmintic activity in comparison to the acetone extract of Spondias Pinnata. The data was verified as statistically significance by using ANOVA at 5% level of significance (P< 0.05).

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