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Investigation of Hepatoprotective Activity of Spondias Pinnata  [PDF]
B. Ganga Rao,N. Jaya Raju
International Journal of Pharma Sciences and Research , 2010,
Abstract: Spondias pinnata (Anacardiaceae) stem heart wood are well known in India as Jangliaam (Hindi), Adavimaamidi, Kondamaamidi (Telugu), Common hog plum, Indian mombin (English) of ethyl acetate and methanolic extracts was prepared and tested for its hepatoprotective effect against carbon tetrachloride induced in rats. Alteration in thelevels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin were tested in both treated and untreated groups. Carbon tetrachloride has enhanced the SGPT, SGOT, ALP and bilirubin levels. Treatment with ethyl acetate extract of S. pinnata stem heart wood (100, 200 and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. This was evident from significant reduction in serum enzyme, SGOT, SGPT, ALP and Total bilirubin (TB).Various pathological changes like centribular necrosis and vacuolization were observed in CCl4 treated rats, which were significant protective activity in groups treated with SP and silymarin. It was concluded from the study that ethyl acetate and methanolic extracts of SP possess hepatoprotective activity against CCl4 induced hepatotoxicity in rats.
Antioxidant and free radical scavenging activity of Spondias pinnata
Bibhabasu Hazra, Santanu Biswas, Nripendranath Mandal
BMC Complementary and Alternative Medicine , 2008, DOI: 10.1186/1472-6882-8-63
Abstract: A 70% methanol extract of Spondias pinnata stem bark was studied in vitro for total antioxidant activity, for scavenging of hydroxyl radicals, superoxide anions, nitric oxide, hydrogen peroxide, peroxynitrite, singlet oxygen and hypochlorous acid, and for iron chelating capacity, reducing power, and phenolic and flavonoid contents.The extract showed total antioxidant activity with a trolox equivalent antioxidant concentration (TEAC) value of 0.78 ± 0.02. The IC50 values for scavenging of free radicals were 112.18 ± 3.27 μg/ml, 13.46 ± 0.66 μg/ml and 24.48 ± 2.31 μg/ml for hydroxyl, superoxide and nitric oxide, respectively. The IC50 for hydrogen peroxide scavenging was 44.74 ± 25.61 mg/ml. For the peroxynitrite, singlet oxygen and hypochlorous acid scavenging activities the IC50 values were 716.32 ± 32.25 μg/ml, 58.07 ± 5.36 μg/ml and 127.99 ± 6.26 μg/ml, respectively. The extract was found to be a potent iron chelator with IC50 = 66.54 ± 0.84 μg/ml. The reducing power was increased with increasing amounts of extract. The plant extract (100 mg) yielded 91.47 ± 0.004 mg/ml gallic acid-equivalent phenolic content and 350.5 ± 0.004 mg/ml quercetin-equivalent flavonoid content.The present study provides evidence that a 70% methanol extract of Spondias pinnata stem bark is a potential source of natural antioxidants.It is increasingly being realized that many of today's diseases are due to the "oxidative stress" that results from an imbalance between formation and neutralization of pro-oxidants. Oxidative stress is initiated by free radicals, which seek stability through electron pairing with biological macromolecules such as proteins, lipids and DNA in healthy human cells and cause protein and DNA damage along with lipid peroxidation. These changes contribute to cancer, atherosclerosis, cardiovascular diseases, ageing and inflammatory diseases [1,2]. All human cells protect themselves against free radical damage by enzymes such as superoxide dismutase (SOD) and catalase,
Medicinal and economic value of spondias mombin
A.O Ayoka, R.O Akomolafe, O.S Akinsomisoye, O.E Ukponmwan
African Journal of Biomedical Research , 2008,
Abstract: This article reviewed the folk medical value of Spondias mombin with the correlated research findings on the uses of Spondias mombin. Most of the folk uses had been scientifically proven in most of the regions where those beliefs are based. The plant was described with habitat, the local uses including the uses of its parts mentioned. We reviewed the ethnomedicinal uses, the biological activities and the phytochemistry of Spondias mombin. (Afr. J. Biomed. Res. 11: 129 - 136) Key Words; Spondias mombin, Neurological, Sedative, Antipsychotic, Antiepileptic, GABA-nergic transmission
Asmaedy Samah
Bulletin of Health Research , 2012,
Abstract: Telah dilakukan suatu penelitian tentang Barringtonia asiatica Kurz. Dua senyawa sapogenin telah dapat dipisahkan dari benih Barringtonia asiatica Kurz. Titik lebur mereka adalah 243-245°C untuk senyawa R1 dan 266-268°C untuk senyawa R2 . Spektrum IR menunjukkan bahwa senyawa R2 memiliki functional groups yang terdiri atas OH, CH, C = C, C -O -C dan CH3 sedangkan senyawa R1 me-miliki functional groups OH, C-H, C = C dan C-O-C dalam strukturnya.
Anthelmintic resistance
Cernea M.,,Anca M?rculescu,,Veturia Ileana Nueleanu
Medicamentul Veterinar , 2007,
Abstract: A thoroughgoing study on resistance was achieved for the first time in insecticides, later on finding that, this can be extended also in anthelmintic substances. The resistance to anthelmintics evolved gradually from a simple medical curiosity, to an important economic problem. Many factors contribute to the appearance of resistance to anthelmintic substances. After epidemiological studies on various helmintic populations, it was concluded that there are four essential and distinguish factors that induce the appearance of parasitic resistance: operational factors, genetic factors, biological and ecological factors. In the last two decades there were conceived many tests to give emphasis to the phenomenon of resistance, but very few were accepted and validated at an international level. The motivation for this phenomenon consist in the fact that every of this methods have a certain sensibility, feasibility and profitableness. All these tests have positive aspects, and few negative aspects, that make themhard to be utilized (apparatus and high costs) or there are not enough sensible, so the obtained results are difficult to be interpreted. The use of molecular technique for the diagnosis of resistance to anthelmintics does not represent a viable option in the present, because the data about the intimate molecular mechanisms of resistance to anthelmintics are very few and there are not confirmed by the clinical reality.
Anthelmintic activity of Neolamarckiacadamba barks
S. Mondal,H. Ramana,P. Suresh.
Hygeia : Journal for Drugs and Medicines , 2011,
Abstract: Present study reports anthelminticactivity of various extracts of the bark of Neolamarckiacadamba (Roxb.) Bosser (Family: Rubiaceae) against Indianearthworms Pheritima posthuma. The results revealed that that allthe tested extracts of N. cadambabark possess anthelmintic activity in adose dependant manner. The activities were comparable with the referencedrug Piperazine citrate. Among the testedextracts, the chloroform extract and pet-ether extract were found to possesspromising anthelmintic activity in comparison to other extracts. The presentstudy therefore justifies its use in the folklore remedies as an anthelminticdrug of natural origin.
Dihydropyranoflavones from Pongamia pinnata
Yin, Hao;Zhang, Si;Wu, Jun;Nan, Haihan;
Journal of the Brazilian Chemical Society , 2006, DOI: 10.1590/S0103-50532006000700034
Abstract: from the stem bark of pongamia pinnata, two new compounds, 3-methoxy-(32,42-dihydro- 32-hydroxy-42-acetoxy)-22,22-dimethylpyrano-(7,8:5 2,62)-flavone and 3-methoxy-(32,42-dihydro-42- hydroxy-32-acetoxy)-22,22-dimethylpyrano-(7,8:5 2,62)-flavone, were isolated, along with six known compounds, caryophyllene oxide, obovatachalcone, 8-hydroxy-6-methoxy-3-pentyl-1h-isochromen-1-one, 6,7,2,2-dimethylchromono-8,g,g-dimethylallylflavanon e, isolonchocarpin, ovaliflavanone a. their structures were determined on the basis of the spectroscopic data interpretation.
Anthelmintic activity of Pongamia glabra
Sunil Ashokrao Nirmal,G. Malwadkar,R.B. Laware
Songklanakarin Journal of Science and Technology , 2007,
Abstract: Leaves, wood, seed, bark and pericarp of the fruit of Pongamia glabra were separately dried, powdered and extracted with methanol in Soxhlet extractor. Anthelmintic activity of these various extracts was evaluatedon Indian adult earthworms, Pherentima posthuma. Results showed that the seed part of P. glabra took less time to cause paralysis and death of the earthworms; therefore, seeds were extracted successively withpetroleum ether, ethyl acetate and methanol in Soxhlet extractor. Again these extracts were screened for anthelmintic activity. Results showed that the ethyl acetate extract of seeds of P. glabra was most potentfollowed by petroleum ether extract. It can be concluded that anthelmintic activity of the seed of P. glabra is due to the active principles present mostly in the ethyl acetate and petroleum ether extracts.
Quazi Majaz A.,Sayyed Nazim,Shaikh Siraj,Shaikh Afsar
International Research Journal of Pharmacy , 2011,
Abstract: The plant Kalanchoe pinnata is widely used in ayurvedic system of medicine as astringent, analgesic, carminative and also useful in diarrhea and vomiting. It is naturalized throughout the hot and moist parts of India. And lots of phytochemical and pharmacological work has done on leaves of plant but the root part is not focused. Hence we have selected roots for pharmacognostic analysis which will support further studies on the root. In this first roots are subjected to microscopic and macroscopic evaluation after which physical parameters were evaluated.
Anthelmintic Activity of Seeds of Macrotyloma uniflorum
Ansa Philip*,Afeefa TP,Athul PV
Hygeia : Journal for Drugs and Medicines , 2009,
Abstract: Many traditional plants and herbs are reported to have anthelmintic activity. Macrotyloma uniflorum is a legume plant which is used as food in India. It is found to have many traditional values such as anthelmintic, diuretic, expectorant, ophthalmic and tonic. The seeds are also useful for haemorroids, tumors, bronchitis, and splenomegaly and in asthma. The anthelmintic activity of the seeds of Macrotyloma uniflorum has been investigated using the ethanolic extract and it was found to have profound activity.
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