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Nanotechnology in Therapeutics: hydrogels and beyond

DOI: 10.1186/1477-3155-5-5

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Abstract:

The very first chapter of this section overviews the "concepts of medical chronobiology, chronopharmacology and chronotherapeutics" as the basis for applications of drug delivery technology" and is dealing with the drug delivery matching to the biological rhythms. Can a doctor who takes decisions on the drug dosage by monitoring patient's progress be replaced by an automated system (see Chapter 2, dedicated to the "Feedback Control in Drug delivery")? Four diseases are analysed in this context and only in the simplest single input case of glucose control in diabetes a feedback control seems to be feasible at present. One of the major non-technical hurdles in this field is the acceptance of the technology by both clinicians and patients.The advances in drug delivery for nanoparticles are discussed in the third chapter of this thrilling volume. The main reason for creating nanoparticles is to improve solubility and bioavailability of drugs. It is a well known phenomenon that nanoparticles can be taken much faster across the cell membranes. There are also opportunities here to create a targeted drug delivery. Routes of nanoparticle preparation are described, followed by the discussion of the requirements to their physical and chemical properties for effective delivery.Molecular recognition is one of the central concepts in biology and is of great importance for the creation of active synthetic nanomaterials. In the Chapter 4 ("Synthetic Ligand-Receptor Interactions in Delivery Systems") the authors are describing what is involved in the design of a synthetic receptor (as opposed to designing a ligand, which is a more common pharmaceutical problem). The next chapter is entitled "Nanoscale Analysis of Mucus-Carrier Interactions for Improved Drug Absorption". It describes the structure of the mucous layer on the molecular level and discusses the interaction of this layer with synthetic polymers.The final sixth chapter of the "intelligent therapeutics" part is dedicated to

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