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Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population

DOI: 10.1186/1471-2350-9-82

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Abstract:

Six polymorphic sites (V4, T+1, T2, T1, S1, and Q-1) were genotyped in 128 patients with AR, 181 patients with AS, and 151 healthy controls (CTR). Genotypes were determined by the polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed using the chi-square test with Haploview software.The single nucleotide polymorphisms (SNPs), V4 G/C, T+1 A/G, and T1 G/A, of the ADAM33 gene may be the causal variants in AR, whereas ADAM33 V4 G/C, T2 A/G, T1 G/A, and Q-1A/G may participate in the susceptibility of AS.These results suggest that polymorphisms of the ADAM33 gene may modify individual susceptibility to AR and AS in a Chinese Han population.Rhinitis is defined as inflammation of the nasal mucosa and is characterised by nasal discharge, blockage, sneezing, and itching [1,2]. Asthma is a chronic inflammatory disorder of the airway which causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing in susceptible individuals. These episodes are usually associated with widespread, but variable airflow obstruction that is often reversible, either spontaneously or with treatment. The inflammation also causes an associated increase in existing bronchial hyper-responsiveness (BHR) to a variety of stimuli [1,2]. Epidemiologic studies have consistently shown that asthma and rhinitis often coexist in the same patients in every region of the world [3-5], suggesting the concept of 'one airway, one disease.' The basic premise is that rhinitis and asthma represent the manifestations of one syndrome in two parts of the respiratory tract [6]. In order to raise awareness of the theory of 'one airway, one disease,' the Allergic Rhinitis and Its Impact on Asthma (ARIA) Workshop Group publication proposes three considerations for patients with allergic respiratory disease [7].ADAM33 is the first reported asthma-susceptible gene identified by positional cloning [8]. ADAM33 is a complex molecule, the expression of which is largely

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