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Association Study on ADAM33 Polymorphisms in Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population  [PDF]
Ruo-Xi Chen, Wen-Min Lu, Lu-Ping Zhu, Mei-Ping Lu, Mei-Lin Wang, Yun-Li Wang, Xin-Yuan Chen, Xin-Jie Zhu, Min Yin, Zheng-Dong Zhang, Lei Cheng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095033
Abstract: Background The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. Objective To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population. Methods In a hospital-based case-control study of 515 patients with mite-sensitized PER and 495 healthy controls, we genotyped seven single nucleotide polymorphisms (SNPs) in ADAM33. Serum levels of eosinophil cationic protein, total IgE and allergen-specific IgE against Dermatophagoides pteronyssinus and Dermatophagoides farinae were measured by the ImmunoCAP assays. Results In the single-locus analysis, three polymorphisms, rs3918392 (F1), rs528557 (S2) and rs2787093, were significantly associated with mite-sensitized PER. SNP S2 was associated with significantly increased risk both of asthmatic and nonasthmatic mite-sensitized PER. In the combined genotypes analysis, individuals with 2–4 risk alleles had a significantly higher risk of mite-sensitized PER (adjusted OR = 1.99, 95% CI = 1.50–2.62) than those with 0–1 risk alleles. Haplotype-based association analysis revealed that the ACAGCCT haplotype might have potential to protect against mite-sensitized PER (adjusted OR = 0.67; 95% CI = 0.49–0.90). Conclusions Polymorphisms in the ADAM33 gene may contribute to susceptibility of mite-sensitized PER in this Chinese population.
Evaluation of Six Years Allergen Immunotherapy in Allergic Rhinitis and Allergic Asthma
Reza Farid,Ramin Ghasemi,Mahmood Baradaran-Rahimi,Farahzad Jabbari
Iranian Journal Of Allergy, Asthma and Immunology , 2006,
Abstract: Allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with IgE-mediated conditions until a dose is reached that is effective in reducing disease severity from natural exposure. In the present study we evaluated a period of six years immunotherapy allergic rhinitis and allergic asthma patients with positive skin prick test of common aeroallergen. The immunotherapy was performed on 156 patients. One hundred twenty of the cases were allergic rhinitis (80%), 29 cases had allergic asthma and 7 cases were mixed (4.5%). 70% in allergic rhinitis group, 75% in allergic asthma group and 42.8% in mixed group completely improved. Immunotherapy, an older therapeutic method, has now been updated, and with appropriate indications, precautions and methods, has been clearly shown to be effective in the treatment of allergic rhinitis and in some cases of asthma and insect hypersensitivity.
The treatment of allergic rhinitis improves the recovery from asthma and upper respiratory infections
Sarti, Willy;Gomes-Monteiro, Lídia Alice;Machado, Claudia Saad Magalh?es;
Sao Paulo Medical Journal , 1995, DOI: 10.1590/S1516-31801995000500002
Abstract: forty-six asthmatic children with repeated respiratory infections presented symptoms of allergic rhinitis. all patients were treated locally for allergic rhinitis either with disodium cromoglycate or beclomethasone dipropionate. after six months of treatment, 95% of the children showed improvement of allergic rhinitis and 84% improvement of bronchial asthma, as well as fewer infections. we concluded that allergic rhinitis plays an important role in facilitating infections of the upper respiratory tract, and a possible association of rhinitis, viral infections and bronchial asthma is discussed.
Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma
Supinda Bunyavanich, Erik Melen, Jemma B Wilk, Mark Granada, Manuel E Soto-Quiros, Lydiana Avila, Jessica Lasky-Su, Gary M Hunninghake, Magnus Wickman, G?ran Pershagen, George T O'Connor, Scott T Weiss, Juan C Celed?n
Clinical and Molecular Allergy , 2011, DOI: 10.1186/1476-7961-9-1
Abstract: To test for associations between variants in TSLP, TSLP-related genes, and AR in children with asthma.We genotyped 15 single nucleotide polymorphisms (SNPs) in TSLP, OX40L, IL7R, and RXRα in three independent cohorts: 592 asthmatic Costa Rican children and their parents, 422 nuclear families of North American children with asthma, and 239 Swedish children with asthma. We tested for associations between these SNPs and AR. As we previously reported sex-specific effects for TSLP, we performed overall and sex-stratified analyses. We additionally performed secondary analyses for gene-by-gene interactions.Across the three cohorts, the T allele of TSLP SNP rs1837253 was undertransmitted in boys with AR and asthma as compared to boys with asthma alone. The SNP was associated with reduced odds for AR (odds ratios ranging from 0.56 to 0.63, with corresponding Fisher's combined P value of 1.2 × 10-4). Our findings were significant after accounting for multiple comparisons. SNPs in OX40L, IL7R, and RXRα were not consistently associated with AR in children with asthma. There were nominally significant interactions between gene pairs.TSLP SNP rs1837253 is associated with reduced odds for AR in boys with asthma. Our findings support a role for TSLP in the pathogenesis of AR in children with asthma.Allergic rhinitis (AR) is a common chronic disease, affecting 10-30% of adults and 40% of children [1]. Characterized by nasal congestion, itching, rhinorrhea, and sneezing, AR decreases school and work productivity. AR is a risk factor for asthma exacerbations and asthma-related hospitalization [2,3]. Up to 80% of children with asthma have AR [4], and treatment of comorbid AR reduces the odds of asthma-related healthcare by up to 80% [5]. A better understanding of the pathophysiology of AR could decrease morbidity in asthmatics and in children overall.The role of thymic stromal lymphopoietin (TSLP) in the pathogenesis of AR has not been extensively studied. TSLP is an interleukin (IL)-7
The Prevalence of Asthma, Allergic Rhinitis and Eczema in North of Iran
Iraj Mohammadzadeh,?Javad Ghafari,?Rahim Barari Savadkoohi,?Ahmad Tamaddoni
Iranian Journal of Pediatrics , 2008,
Abstract: Objective: Asthma, allergic rhinitis and eczema as a common chronic disorder in childhood, has many epidemiologic variations in different geographic areas. Uniform and standard epidemiologic researches are able to clear and modify scientific questions in this field. We carried out this study to determine the prevalence and intensity of pediatric allergic disease in our region.Material & Methods: This analytical-cross sectional study was performed on 2 groups of children; the first group aged 6-7 years (n=3240) and the second group aged 12-14 years (n=3254) during 2002-03. According to ISAAC programming, sample size consisted of 3000 children in each group. From all students 99.3% of primary students and 88.8% of guidance students entered into study. Data was gathered by ISAAC first phase questionnaire and analyzed by SPSS 10 and Chi square test.Findings: The 12-month prevalence rates of symptoms were as follow: wheezing 16.8% and 21.7%, allergic rhinitis symptoms 14.5% and 19.9% and atopic dermatitis symptoms 4.5% and 8.2%, for younger and older age group, respectively. The prevalence of wheezing and current wheeze did not show differences according to sex (P>0.05) but it was significantly higher in students of guidance school (P<0.05). The prevalence of previous history of asthma, speech disorders, wheezing after physical exercises and dry cough at night, rhinoconjuntivitis, recurrent rhinitis, eczema with pruritus, recurrent lesions and history of eczema was significantly higher in boys and in students of guidance school (P<0.05). The prevalence of flexor lesion did not show a significant difference according to age (P>0.05) but in boys it was higher than in the girls (P<0.05).Conclusion: According to our findings asthma, allergic rhinitis and eczema have a moderate prevalence in this region of our country.
The Impact of Allergic Rhinitis and Asthma on Human Nasal and Bronchial Epithelial Gene Expression  [PDF]
Ariane H. Wagener, Aeilko H. Zwinderman, Silvia Luiten, Wytske J. Fokkens, Elisabeth H. Bel, Peter J. Sterk, Cornelis M. van Drunen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080257
Abstract: Background The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. Objective Defining gene expression profiles of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles. Methods This cross-sectional study included 18 subjects (6 allergic asthma and allergic rhinitis; 6 allergic rhinitis; 6 healthy controls). The estimated false discovery rate comparing 6 subjects per group was approximately 5%. RNA was extracted from isolated and cultured epithelial cells from bronchial brushings and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array). Data were analysed using R and Bioconductor Limma package. For gene ontology GeneSpring GX12 was used. Results The study was successfully completed by 17 subjects (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls). Using correction for multiple testing, 1988 genes were differentially expressed between healthy lower and upper airway epithelium, whereas in allergic rhinitis with or without asthma this was only 40 and 301 genes, respectively. Genes influenced by allergic rhinitis with or without asthma were linked to lung development, remodeling, regulation of peptidases and normal epithelial barrier functions. Conclusions Differences in epithelial gene expression between the upper and lower airway epithelium, as observed in healthy subjects, largely disappear in patients with allergic rhinitis with or without asthma, whilst new differences emerge. The present data identify several pathways and genes that might be potential targets for future drug development.
Descriptive Study of 226 Patients with Allergic Rhinitis and Asthma
Abolhassan Farhoudi,Alireza Razavi,Zahra Chavoshzadeh,Marzieh Heidarzadeh
Iranian Journal Of Allergy, Asthma and Immunology , 2005,
Abstract: The prevalence of allergic diseases such as asthma and allergic rhinitis is high in general population and aeroallergens are the most common allergens that cause air way inflammation. The aim of this study was an evaluation of clinical and laboratory findings in allergic patients and identification of the most common aeroallergen in these patients. A cross–sectional retrospective study was conducted on 226 allergic patients who were referred to allergic clinic of Karaj city, and skin prick test response to aeroallergens were studied. The most common risk factors in these patients were total IgE more than 100 IU/ml and a positive family history of atopy. Skin prick testing results showed that the most common aeroallergens were: herbacee II (62%), sycamore (57%), chenopodium (53%), tree mix (50%), herbacee III (47%), grass (43%), ash (40%), herbacee I (37%), cedar (27%), cockroach (25%), and mite D.P (19%), D.F (18%). High prevalence of skin reactivity to weeds (chenopodium and herbacee) and sycamore indicates variation in the prevalence of aeroallergen reactivity in different regions with different climates.
Determinants of Allergic Rhinitis in Young Children with Asthma  [PDF]
Lise Moussu, Philippe Saint-Pierre, Virginie Panayotopoulos, Rémy Couderc, Flore Amat1, Jocelyne Just
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097236
Abstract: Background In the preschool period, allergic rhinitis (AR) is infrequent and thus under-diagnosed. However, recent works have highlighted the occurrence of AR in toddlers although the causes of AR in this young population remain unknown. The objective of this study was to identify determinants of AR in young children with asthma. Methods We carried out a case-control study of 227 children with active asthma and enrolled in the Trousseau Asthma Program. AR and other allergic diseases (asthma, food allergy and eczema) were diagnosed by medical doctors using standardized questionnaires. Parental history of AR and asthma, biological markers of atopy (total IgE, blood eosinophilia, allergic sensitization towards food and aeroallergens) and environmental parameters were also collected. Results Forty one of the children (18.1%) had AR. By univariate logistic regression analysis, AR was mainly associated with peanut sensitization (OR = 6.75; p = 0.002); food allergy (OR = 4.31; p = 0.026); mold exposure (OR = 3.81 p<0.01) and parental history of AR (OR = 1.42; p = 0.046). Due to the strong link between food allergy and peanut sensitization three models of multivariate logistic regression were performed and confirmed that AR is associated with peanut sensitization but also food allergy and mold exposure. A random forest analysis was also performed to explain AR. The results reinforced the logistic analysis that peanut sensitization and mold exposure were the principal determinants of AR. Conclusions & Clinical Relevance These results stress the importance of investigating AR in young children with asthma to potentially diagnose a particularly severe allergic asthmatic phenotype. Moreover, these data evoke the hypothesis that peanut could be an aeroallergen.
Treatment trends in allergic rhinitis and asthma: a British ENT survey
Ravinder S Natt, Petros D Karkos, Davinia K Natt, Eva G Theochari, Apostolos Karkanevatos
BMC Ear, Nose and Throat Disorders , 2011, DOI: 10.1186/1472-6815-11-3
Abstract: A questionnaire was emailed to all registered consultant members of the British Association of Otorhinolaryngologists - Head and Neck Surgeons regarding the management of patients with Allergic Rhinitis and related disorders.Survey response rate was 56%. The results indicate a various approach in the investigation and management of Allergic Rhinitis compatible with recommendations from the Allergic Rhinitis and Its Impact on Asthma guidelines in collaboration with the World Health Organisation.A combined management approach for patients with Allergic Rhinitis and concomitant Asthma may reduce medical treatment costs for these conditions and improve symptom control and quality of life.The definition of Allergic Rhinitis (AR) was formulated by Hansel in 1929 [1]. It is a symptomatic nasal disorder caused by allergen exposure through an IgE-mediated immune response against allergens. AR can be subdivided into intermittent (symptoms <4 days per week or for <4 weeks) and persistent disease (symptoms >4 days per week or for >4 weeks) and is further characterized according to severity as mild or moderate/severe [2].The nasal passage and paranasal sinuses are an integral part of the respiratory tract and patients may have rhinitis without sinusitis, but not sinusitis without rhinitis, hence the term rhinitis has been replaced in modern ENT literature by the more accurate term rhinosinusitis [3]. AR and Asthma are linked epidemiologically, pathologically, physiologically and therapeutically and can be considered as a manifestation of a single inflammatory airway syndrome [4]. Most patients with Asthma have rhinitis suggesting the concept of "one airway, one disease" [5]. AR is more prevalent than Asthma and a European population study was reported to have an AR prevalence rate of 25% [6]. AR usually precedes Asthma and can be considered as risk factor for the development of Asthma. Rhinitis exists in up to 80% of Asthma patients and frequently exacerbates Asthma and increase
The Detection of Allergic Rhinitis in Schoolchilden with Bronchial Asthma in Engels: Results of Retrospective Analysis  [PDF]
J.A. Tsareva
Saratov Journal of Medical Scientific Research , 2012,
Abstract: The research goal of the study was to assess frequency of allergic rhinitis diagnostics in schoolchildren with bronchial asthma and to evaluate treatment approaches to combined allergic pathology of respiratory tract in clinical practice. Materials: Retrospective analysis of medical records of all asthmatic schoolchildren in-patients admitted in 2003-2010 has been performed. 240 patients have been included in the study. Results: 61.7% schoolchildren had symptoms suspicious of allergic rhinitis. Nevertheless, the diagnosis of allergic rhinitis was established only in 56 patients (23.3%). Obviously, children with allergic rhinitis or nasal symptoms had more severe clinical course of asthma. The latter required significantly more frequent and intensive use of prolonged broncholytics in order to enhance the anti-inflammatory treatment (inhalation corticosteroids) (p < 0.05). Conclusion: in schoolchildren with bronchial asthma allergic rhinitis is diagnosed inadequately (insufficiently). This fact does not allow to start treatment intime and ipso facto to improve the clinical course of bronchial asthma.
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