The aim of the investigation is to develop an adequate pathogenetically supported algorithm of correction of combined pathology of male sexuality relying on pathogenetic aspects of its formation. Materials and methods. There were analyzed the treatment results of 120 men with chronic prostatitis, prostatic hyperplasia, and impotency. 60 men received traditional treatment, and 60 men were treated according to the developed algorithm. Results. The proposed algorithm of combined therapy of sexual pathology, including chronic diseases of the prostate gland and sexual dysfunction with primary correction of sexual status taking into account the specificity of pathogenesis in each case was found to be reliably more effective than the attempts to restore sexual status under traditional urologic approaches aimed at minimizing symptoms indicating at first glance a possible organic lesions of the prostate gland.