全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Risperidone versus zuclopenthixol in the treatment of schizophrenia with substance abuse comorbidity: a long-term randomized, controlled, crossover study

DOI: 10.4321/S0213-61632006000300001

Keywords: schizophrenia, substance use disorders, dual diagnosis, risperidone, zuclopenthixol.

Full-Text   Cite this paper   Add to My Lib

Abstract:

background: substance use disorders (suds) are present in more than 50% of subjects diagnosed with schizophrenia. however, there are no controlled studies assessing the efficacy of antipsychotic drugs in this subgroup of patients. the aim of the present work was to compare the efficacy of risperidone and zuclopenthixol in a sample of schizophrenic subjects with dual diagnosis. method: thirty-three male were selected for treatment with risperidone, while another 33 were treated with zuclopenthixol. substances most commonly used were alcohol, cannabis (both 82%) and cocaine (32%). patients were randomized and treated for the first six months with one antipsychotic and the second six months with the other antipsychotic. psychopathological and clinical scales were used every two months. participants received training on how to reduce their consumption of substances (substance abuse management module, samm). results: during the first six months risperidone group patients presented fewer positive urine tests and showed better compliance with the samm programme. in the second period the patients treated with risperidone significantly improved their scores on the panss-negative subscale. differences between the cgis indicated that the subjects who moved from risperidone to zuclopenthixol worsened, while those who moved from zuclopenthixol to risperidone significantly improved. conclusions: risperidone was more effective than zuclopenthixol in improving the symptoms of schizophrenia and substance use.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133