All Title Author
Keywords Abstract


El papel de la inmunidad innata en la obesidad

DOI: 10.1590/S0036-36342012000200014

Keywords: toll-like receptor, obesity, inflammation, insulin resistance.

Full-Text   Cite this paper   Add to My Lib

Abstract:

obesity in mexico is alarmingly increasing in prevalence in adults and children, and it is a risk factor for the development of insulin resistance, as well as, of other metabolic alterations. the discovery of the expression of the toll-like receptors (tlrs) in adipocytes, suggests an important role in innate immunity. in different models of obesity, there has been observed an increase of tlrs expression in the fat tissue, therefore tlrs could be involved in systemic inflammation in this disease, and in the development of insulin resistance. tlr activation is mediated by fatty acids and their expression is regulated by leptin, adiponectin and ppars. knowledge of the role of tlrs in inflammation and adipocyte differentiation and their regulation, then it is important to try to develop new therapeutic anti-inflammatory targets that contribute in the treatment of obesity.

Full-Text

comments powered by Disqus