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Liver histology in co-infection of hepatitis C virus (HCV) and Hepatitis G virus (HGV)

DOI: 10.1590/S0036-46652002000200003

Keywords: hepatitis c, hepatitis g, liver fibrosis, inflammatory activity.

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Abstract:

as little is known about liver histology in the co-infection of hepatitis c virus (hcv) and hepatitis g virus (hgv), hgv rna was investigated in 46 blood donors with hepatitis c, 22 of them with liver biopsy: co-infection hcv / hgv (n = 6) and hcv isolated infection (n = 16). besides staging and grading of inflammation at portal, peri-portal and lobular areas (brazilian consensus), the fibrosis progression index was also calculated. all patients had no symptoms or signs of liver disease and prevalence of hgv / hcv co-infection was 15.2%. most patients had mild liver disease and fibrosis progression index, calculated only in patients with known duration of infection, was 0.110 for co-infection and 0.130 for isolated hcv infection, characterizing these patients as "slow fibrosers". no statistical differences could be found between the groups, although a lesser degree of inflammation was always present in co-infection. in conclusion co-infection hcv / hgv does not induce a more aggressive liver disease, supporting the hypothesis that hgv is not pathogenic.

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