the purpose of this study was to determine the degree of concordance between radiological and radioisotopic methods and, if positive, to evaluate the usefulness of ictal spect in the localization of the epileptogenic focus. ictal brain spect, magnetic resonance imaging (mri) and magnetic resonance spectroscopy (mrs) were performed on six patients with refractory temporal lobe epilepsy. ictal spect was performed after withdrawal of the anti-epileptogenic drugs during video-eeg monitoring, using 99mtc-ecd, administered to patients at the time of the ictus. mri was performed in t1, t2 and flair sequences and mrs was obtained using the press technique, with a single voxel positioned in both hippocampi. the statistical analysis included the determination of the values of kappa (k), standard error (se) and significance level (p) for the lateralization of the ictal focus. the analysis of all findings was based on eeg localization of the ictal discharge, seizure duration (109-280 s; 152 s average) and time of radiotracer injection (30-262 s; 96 s average). we obtained correlated data in four patients (67%), and values of k = 0.67, se = 0.38, and p = 0.041. we concluded that there is a concordance between ictal spect, mri and mrs data and the usefulness of the radioisotopic procedure is related to a nondiagnostic eeg and when there is a discordant or misleading diagnosis after a comparative analysis of eeg and mrs.