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Jun 20, 2025Open Access
Background: Diabetes is one of the most widespread metabolic diseases worldwide and is responsible for approximately 4 million deaths per year in 2010. The global prevalence among adults was estimated at 4.6% affecting around 285 million people. This number rose to 371 million in 2012 and is projected to reach 552 million by 2030. Among the various factors that may influence the incidence of diabetes, infection with Helicobacter pylori has been increasingly studied for ...
Mar 25, 2025Open Access
Introduction: DM has been implicated with multiple complications including diabetic cardiac autonomic neuropathy (DCAN), with a global burden ranging from 1% - 90% in type 1 DM and 20% - 73% in type 2 DM. Poor glycemic control, long duration of DM and traditional cardiovascular risk factors have been associated with the development and progression of DCAN. In Tanzania, there is limited data on DCAN burden and its associated factors. This study was conducted to raise awareness ab...
Dec 24, 2024Open Access
Introduction: Paraneoplastic Cushing’s syndrome is a condition representing a small-on average, a 10% fraction-of the cases of Cushing’s syndrome and affects 1% - 5% of patients with small-cell lung cancer. Case Presentation: We presented a patient with paraneoplastic Cushing’s syndrome due to small-cell lung cancer. Conclusion: This combination means a poorer prognosis with a shorter survival rate than other separate diagnoses.
Dec 11, 2024Open Access
Diabetic Eye Disease (DED) is a growing public health concern worldwide, with rising global diabetes prevalence, effective public health strategies are essential to combat DED. This paper discusses key strategies for the prevention and management of complications at a population level, including early detection through regular screenings, improving access to care, raising awareness, implementing robust policy frameworks, leveraging technological advancements, and involving communities. These app...
Nov 15, 2024Open Access
Background: Diabetic ketoacidosis (DKA) in pregnancy is a life-threatening condition for both the mother and the fetus. This condition is often associated with type 1 diabetes, but it can also complicate type 2 diabetes and rarely complicates gestational diabetes. DKA in pregnancy often occurs in the 3rd trimester of pregnancy and its prevalence is worryingly increasing. Timely diagnosis and appropriate management of DKA are crucial to decreasing the maternal-fetal complications...
Nov 11, 2024Open Access
Purpose: To determine the morphological classification, associated factors and prevalence of anaemia among T2DM patients at Fort Portal Regional Referral Hospital, Southwestern Uganda. Methods: This cross-sectional study enrolled 230 T2DM patients, 60 (26.1%) males and 170 (73.9%) females. The socio-demographic characteristics were collected using structured questionnaires, 4ml of venous blood was collected from each study participant into an EDTA vacutainer. Th...
Oct 31, 2024Open Access
Background and Objectives: Kruppel-Like Factor 14 (KLF14) is defined as a master regulator of gene expression in adipose tissue and has been associated with body mass index (BMI) and type 2 diabetes (T2D). Genome-wide association studies aim to find predictive biomarkers for the development of type 2 diabetes, taking into account epigenetic changes affected by environmental factors. DNA methylation plays a decisive role in the regulation and control of gene expression. The objec...
Jul 31, 2024Open Access
Introduction: DM has been implicated with multiple complications including diabetic cardiac autonomic neuropathy (DCAN), with a global burden ranging from 1% - 90% in type 1 DM and 20% - 73% in type 2 DM. Poor glycemic control, long duration of DM, and traditional cardiovascular risk factors and other factors have been associated with the development and progression of DCAN. This study was conducted to evaluate the common DCAN-associated risk factors and their percentages in dia...
Mar 18, 2024Open Access
Coronary artery spasm (CAS) is the most common diagnosis in patient with non-obstructive coronary artery disease (INOCA). CAS has a great relation with the thyrotoxicosis. It leads to severe reversible coronary vasoconstriction with wide varieties of symptoms from just simple chest pain to sudden cardiac death. Many trials and investigations are still going on to reveal the pathophysiology and the mechanism. The symptoms may mimic acute coronary syndrome so the corner stone in the diagnosis is t...
Sep 07, 2023Open Access
The incidence of end-stage renal disease (ESRD) is increasing in the Philippines. The presence of diabetes mellitus further worsens ESRD prognosis. The neutrophil-to-lymphocyte ratio (NLR) is a reliable prognostic marker for mortality, but its usefulness as a prognostic biomarker in diabetes patients with chronic kidney disease is yet to be clarified. This study aimed to determine the association between NLR and morbidity among Filipino patients with end-stage renal disease (ESRD) secondary to d...
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