OALib Journal
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Feb 28, 2019Open    AccessArticle

Effect of Dioscorea Pills on Immunity of Mice Receiving Chemotherapy for Ovarian Cancer

Yiming Tang, Huijun Xu
Objective: To observe the effect of Dioscorea pills on the immunity of mice with ovarian cancer after chemotherapy and its mechanism of action. Methods: BALB/C mice were randomly divided into blank group, ovarian cancer model group, chemotherapy group and chemotherapy plus TCM (Traditional Chinese Medicine) group with 20 mice in each group. Except the blank group, 60 mice in other groups were subcutaneously injected with SKOV-3 ov

Nov 28, 2017Open    AccessArticle

The Novel Patient with BLNK Gene Type of Agammaglobulinemia

Gulnara Mahammadali Nasrullayeva, Vafa Rustam Mammadova, Afaq Vladimr Khalilova, Shabnam Eldar Shahgeldiyeva
Background: Agammaglobulinemia (AGM) is a genetic immune system disorder in which the body could not produce antibodies. There are two types of this disease: X-linked AGM (XLA) and autosomal forms. X-linked agammaglobulinemia results from a mutation in the gene for Bruton’s tyrosine kinase (BTK), found on the X chromosome. Mutations in BTK result in lack of mature B-cells and immunoglobulins of all classes. Th

Apr 27, 2017Open    AccessArticle

JAK-STAT Lodges in Multiple Sclerosis: Pathophysiology and Therapeutic Approach Overview

Kabir Magaji Hamid, Abdullahi Isiyaku, Mustapha Umar Kalgo, Isah Suleiman Yahaya, Abbas Mirshafiey
Multiple sclerosis (MS) is a complex inflammatory and demyelinating disease of central nervous system (CNS). The disease pathogenesis is not fully understood and no actual cure for the disease yet. The disease has genetic and environmental cause as fundamental factors which are identified for the disease pathogenesis so far. One of the characteristic features of the disease is inflammation cause due to activation of pro-inflammato

Apr 12, 2017Open    AccessArticle

Virological and Serological Markers in Dengue Patients from Venezuela and Nicaragua

Didye Ruiz, Susana Vázquez, Elci Villegas, Angel Balmaseda, Maritza Pupo, Mayling Alvarez, Delfina Rosario, Herminia Bendezu, Naifi Calzada, Maria G. Guzman
Latest estimates suggest 390 million infections of dengue occur each year, of which 100 million results in symptomatic disease. The new clinical classification proposed by WHO-TRD 2009 simplifies dengue fever (DF) into dengue (D) and severe dengue (SD) with an intermediary group of “dengue with warning signs” (DWS). Early, sensitive and specific diagnosis of dengue is needed for appropriate patient managem

Nov 29, 2016Open    AccessArticle

Immunoglobulin A Antibody Responses in Patients with Primary or Secondary Dengue Infections

Didye Ruiz, Susana Vázquez, Hernán C. Ríos, Naifi Calzada, María G. Guzmán
IgM serological diagnostic plays an important role in the dengue epidemiological surveillance. However, IgA has been identified as a possible diagnostic marker for early stage and recent infections. The aim of this study was to know the IgA response in dengue patients in relation to type of infection, serotype specificity and role as early and recent infection marker. IgA behavior in dengue patients, using a method de

Aug 03, 2016Open    AccessArticle

Shared Autoimmunity: A Case Series of 56 Patients with Immune Thrombocytopenia (ITP) Associated with Other Autoimmune Disorders

Lizbeth-Estefanía Díaz-Polo, Núria Pujol-Moix, Blanca Jiménez, Carme Canals, Edgardo Barranco-Charris, Eduardo Muniz-Díaz, Juan-Carlos Souto
The association of two or more autoimmune disorders in the same individual has been attributed to “shared autoimmunity” caused by the interaction between genetic and environmental factors. We present the retrospective analysis of 56 patients with Immune Thrombocytopenia (ITP) associated with other autoimmune disorders. Age, sex, clinical manifestations, platelet count, platelet autoantibodies and therapeutic responses were similar

Jun 15, 2016Open    AccessArticle

Assessment of Immunization Status, Coverage and Determinants among under 5-Year-Old Children in Owerri, Imo State, Nigeria

Chukwuma B. Duru, Anthony C. Iwu, Kenechi A. Uwakwe, Kevin C. Diwe, Irene A. Merenu, Chima A. Emerole, Chioma A. Adaeze, Chinwe U. Onyekuru, Obinna Ihunnia
Background: Immunization coverage in different parts of the country varies widely despite efforts to improve the services. The immunization status of children is dependent on the dynamics of vaccination uptake which is complex and involves the interplay of different associated factors. Aim: To determine the immunization coverage, status and the determinants in under 5-year-old children in Owerri municipal, Imo State. Methods: The

Nov 10, 2015Open    AccessArticle

Seroprevalence of Brucellosis in Sheep and Cow Herds of Kermanshah Province by Conventional Methods during the Period 2008 to 2013

Saeed Salari, Mehrdad Pooyanmehr, Ahmad Rashki, Shaghayegh Peykani
Aim: Brucellosis, as a zoonotic disease, is characterized by reduced fertility in animals. This study has aimed to assess the prevalence of brucellosis in sheep and cows rearing in Kermanshah Province. Methodology and Results: The study was conducted in the regions of Kermanshah whereas people had seropositive results for brucellosis. Serum samples of sheep and cow flocks were screened using tow conventional methods. The sheep was the most ruminant infected with brucella. The most seropos...

Sep 25, 2015Open    AccessArticle

Storage of Blood for Transfusion in Domestic Refrigerators: Any Immune Consequences?

Samuel S. Antwi-Baffour, Ransford Kyeremeh, Alhassan Shaibu, Jonathan Adjei, Mahmood S. Abdulai
Background: Blood storage particularly for transfusion is a common practice among Medical Laboratory Scientists. However, haemolysis of blood during storage is inevitable but the degree of occurrence is largely dependent on the mode of storage, which has not been fully investigated. Aim: The aim of this study was to measure and compare the extent of haemolysis in blood for transfusion stored in domestic and medical laboratory refrigerators. Methods: Haemolysis was compared from day one up to day...

Jun 12, 2015Open    AccessArticle

Concept Analysis: Engagement in Personal HIV Management

Matt L. Pimentel
A concept analysis is an endeavor in social sciences to ensure proper usage of the term among researchers, theorists, and practitioners. The concept of engagement has recently been touted as the term describing HIV-infected individuals who are compliant with their highly active antiretroviral therapy (HAART) medications. Accordingly, engagement has also come to mean that the full compliance with not just HAART, but also compliance with lab tests, medical visits, and counseling services. Post-rel...