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Jul 21, 2023Open Access
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Feb 09, 2023Open Access
Kodamaea ( Pichia) ohmeri is a rare and emerging yeast-like fungus that belongs to the ascomycete group and Saccharomycetaceae family. It is an important pathogen in immunocompromised patients, they were reported as fungemia, funguria, endocarditis, peritonitis and wound infections causing necrotising fasciitis. We describe a case where Kodamaea ohmeri isolated from peritoneal infection in an elderly patient that came with retroperitoneal collection as a complication o...
Jan 28, 2023Open Access
Context: Sickle cell disease is the most widespread genetic hematological disease in the world and constitutes a real public health problem with an increasingly increasing prevalence. Objective: The objective of this study was to determine the profile of patients who consulted at the Center for Mixed Medicine and SS Anemia in Kinshasa. Methods: A retrospective descriptive study of the data available in the files of patients who consulted the CMMASS during the period from January 1, 2018 to Decem...
Jan 04, 2023Open Access
Background: Sickle cell disease is an autosomal recessive hereditary hemoglobinopathy. Patients with sickle cell disease (HbSS, Sβ, SC phenotypes) with permanent hemolytic anemia very often require transfusions. Objective: To describe the socio-demographic and clinical characteristics of polytransfused sickle cell patients in Kinshasa. Methods: This is a descriptive cross-sectional study of polytransfused sickle cell patients followed at the SS Anemia Mixed Medicine Center (CMMASS). Socio-demogr...
Nov 25, 2022Open Access
It’s been more than two years since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in Wuhan, China, in December 2019, and still Coronavirus-19 (COVID-19) is an ongoing burden in many parts of the world. Currently, few vaccines are approved by the World Health Organization (WHO) and are being administered to people to boost their immunity. Since the outbreak of this disease, the number of patients getting vaccinated is increasing with every passing day...
Sep 30, 2022Open Access
Context: For several decades, the introduction of AntiRetroViral (ARV) has allowed an improvement in the clinical signs of patients, a spectacular reduction in mortality and morbidity, an extension of life and an improvement in the quality of life of many People Living with HIV (PLHIV). Objective: The objective of this study was to determine the clinical profile of PLHIV starting ARV Treatment in Kinshasa in the era of Dolutegravir. Methods: This study is a descriptive cross-sectional study to d...
May 18, 2022Open Access
The human immune system relies on the dynamic, complex integration of various cells, proteins, tissues, and organs which work together in concert with the nervous system to recognize, adapt to, and neutralize pathogens. In parallel, there is a neurobiological network of systems which function to react and adapt to changes in the environment to restore and maintain homeostasis in the service of survival. Our dependency on the stability and resilience of this collective ecosystem of responses is a...
Apr 25, 2022Open Access
Background: Clinical values derived from groups of apparently normal individuals are used for the determination of reference ranges. Only individuals with good health are recruited as blood donors and so can form a suitable cohort for the development of reference intervals. Reference intervals are necessary in interpreting and making critical decisions in diagnostic and research purposes. In this cross-section study, male and female selected biochemical values were determined on blood donors att...
Jan 14, 2020Open Access
A phenocopy is defined as a clinical non-inherited phenotype in an indi-vidual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (Interna-tional Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with con-ditions that are not part of the innate alterations and are ca ...
Feb 28, 2019Open Access
Objective: To observe the effect of Dioscorea pills on the immunity of mice with ovarian cancer after chemotherapy and its mechanism of action. Methods: BALB/C mice were randomly divided into blank group, ovarian cancer model group, chemotherapy group and chemotherapy plus TCM (Traditional Chinese Medicine) group with 20 mice in each group. Except the blank group, 60 mice in other groups were subcutaneously injected with SKOV-3 ov ...
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