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Mar 27, 2024Open Access
Mohs technique is a precise method for removing skin tumors that, during excision, preserves healthy tissue. Common skin tumors treated with this technique are squamous and basal cell carcinoma. The American College of Mohs Surgery has established guidelines for the use of the technique. Tumor localization, patient characteristics, and tumor features should be considered when assessing whether this technique is the right choice. It’s useful in regions such as eyelids, lips and genitals. There ar...
Aug 29, 2023Open Access
Background: The use of flaps is an important procedure in Plastic Surgery for the coverage of traumatic wounds, oncological resections, and burn reconstruction, among others. Drugs such as vasodilators (isoxsuprine, nitroglycerin), could increase tissue perfusion to optimize flap viability. In this study, the local and systemic effects of the use of topical nitroglycerin to increase the survival area of skin flaps were analyzed in a murine model. Methods: In our pilot study, we included twenty m...
Jul 21, 2023Open Access
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Nov 26, 2019Open Access
Traditional Chinese Medicine (TCM), especially the extractive, has been ex-tensively used in clinical practices and proven to be effective against cancer. However, the underlying mechanisms remain to be investigated. In this study, we evaluated the anti-melanoma activity of the extractive Crocin (CRO) from the Chinese herbals saffron. After corresponding time of oral administration, CRO can’t obviously decrease the proliferation o ...
Apr 19, 2018Open Access
Objective wrinkle grading
scales have been described for Caucasians and Japanese, but none for South-east
Asians. Southeast Asians tend to be darker in skin complexion (usually skin
types IV and above). A wrinkle scale using fairer Caucasian and Japanese skin,
may not be easily applicable for the darker Southeast Asian skin. Therefore, in
this paper, we describe and validate a wrinkle grading ...
Apr 19, 2018Open Access
Purpose: Wrinkles
are the most visually obvious features of aging and are the prime target of a
vast number of products (both medical and cosmetic). It is important for
clinicians to be able to grade wrinkles objectively. Although wrinkles are
easily recognisable for humans, it remains a very challenging task for computer
vision systems to detect them automatically. In our center, we developed a
wrinkle detection algorithm based o ...
Jul 28, 2017Open Access
The dermatologic
manifestations of porphyrias result from localized cutaneous formation of
reactive oxygen species. The significance of these inflammatory mediators may
extend beyond the skin, as increased oxidative stress may play a role in the
systemic manifestations of porphyrias. Polypodium
leucotomos is a tropical fern that has demonstrated antioxidant,
ant ...
Jul 27, 2016Open Access
Keloid pathogenesis
occurs due to the longer duration of inflammation and the increase in the
production of several factors such as TGF-β1
that causes the increase of fibroblast proliferation and collagen synthesis.
The role of B4 Leukotriene (LTB4) in keloid pathogenesis particularly in the
inflammation phase and tissue proliferation has not been clearly elucid ...
Oct 19, 2015Open Access
Background: Human growth factors serve as secretomes that regulate skin
cell proliferation/differentiation and production of extracellular elements
of the matrix and treat photo-aging. Microneedling of skin can also improve
aging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmetic
benefits. Objectives: This open, randomized split-face and single-center
controlled study evaluated the safety and efficacy of the application of a
cosmeceutical form...
Apr 01, 2015Open Access
Introduction: The bacterial nosocomial infection remains a common cause of death in patients who have sustained a severe burn injury. Material and Methods: We conducted a
prospective study of 45 patients hospitalized in the ICU burns Hospital IBN-ROCHD
of Casablanca over a period of six months, from 1 January 2014 to 30 June 2014.
The criteria for nosocomial infection were those of the Center for Disease
Control in Atlanta in 1988. Result: Incidence rates were calculated. The
bacterial ecology o...
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