Estimation of lipoproteins levels & risk of cardiovascular disease in psoriasis.

Introduction Psoriasis is a chronic inflammatory & most common dermatologic diseases. It is related to several diseases but most common is cardiovascular disease. Lipid abnormalities are observed in psoriasis patients at the earliest stages of the disease and so it may be genetically determined.Hence there is a great need to study lipid abnormalities in psoriatic patients, which will help us to evaluate the level of risk individuals may experience for developing atherosclerosis and vascular obstructive disorders, as well as associated morbidity and mortality. Aim: To estimate lipoproteins levels & related risk of cardiovascular diseases in psoriasis patients Materials and Methods: This is a community-based cross sectional analytical study. The study population was derived from the healthy ambulatory person in and around Pimpri area & was conducted in Dr. D.Y.Patil Medical College & Hospital, Pimpri Pune. Study group consist of 40 psoriatic patients with mean age of 50.68 ± 8.86 years and control group consisted of 40 healthy individual of either sex with mean age of 50.15 ± 9.6 years. 55 % males & 45 % females were present in control group while test group comprises of 59 % males & 41 % females. estimation of Serum total cholesterol, Serum triglyceride, Serum High-Density Lipoprotein-cholesterol & Serum Low density Lipoprotein levels were done the same day. Estimation of lipoproteins levels done by Enzymatic End Point Method. Tha data was analysed by calculating mean, standard deviation, p-value and Chi-square test. Results : Findings of this show that, total cholesterol ,VLDL was significantly increased in psoriasis compared to control(p<0.05).Difference between psoriasis cases(6.8 ± 1.49) and control (3.08 ± 1.3) in findings of serum TGs were highly significant(p<0.001).However, difference in between serum LDL level in psoriasis cases and control was not significant. There were no significant changes shown in serum HDL level in both psoriasis cases and control . LDL/HDL ration has not shown any significant changes in both psoriasis case and control, while in TC/HDL ratio, difference was statistically significant(p<0.05). Conclusion: Present study suggests that patients with psoriasis were associated with hyperlipidaemia. So have high risk of developing the cardiovascular diseases. We suggest that screening of serum lipid profile in psoriatic patients will help in evaluating risk at early stage. Impromptu treatment in these patients will prevent the risk of cardiovascular diseases.