Background: Like many chronic skin diseases, psoriasis has a psychological impact on the sufferer and a huge impact on quality of life. The aim of the study is to estimate the prevalence of depression and anxiety among patients suffering from psoriasis in a region of Morocco, and to identify sociodemo-graphic, disease-related, and quality of life associated factors. Materials and Methods: A cross-sectional study was carried out in the dermatology department of the Hassan II University Hospital in Fez between September 2019 and December 2020 on patients with psoriasis. The Hospital Anxiety and Depression Scale were used to measure depression and anxiety, and the 12-item Short Form survey to measure Quality of Life. A multivariate analysis was used to determine associated factors. Results: Results: A total of 133 participants were included, with men slightly predominant at 70 (52.6%). Of the participants, 67.7% were aged 35 years or older, and duration of psoriasis greater than 3 years was predominant at 79.7%. The prevalence of depression was 28.6% with a 95% CI (20.9 - 36.2), and anxiety was 41.4% with a 95% CI (33.0 - 49.7). The mean scores for mental (MCS-12) and physical (PCS-12) quality of life were 36.4 ± 7.0 and 35.9 ± 5.8, respectively. Depression was associated with advanced age, female gender, married status, high affected body surface area, and low MCS-12, while anxiety was associated with advanced age, pruritus, and low MCS-12. Conclusion: Our results suggest that it is important to establish the detection of mental health disorders and assess the impact of psoriasis on patients’ quality of life, particularly in terms of mental quality, as part of psoriasis care.
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