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Prevalence and Risk Factors of Dilated Cardiomyopathy among Yemeni Patients with Heart Failure

DOI: 10.4236/oalib.1109459, PP. 1-25

Subject Areas: Cardiology

Keywords: Dilated, Cardiomyopathy, Heart Failure, Yemen

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Abstract

Background: Idiopathic dilated cardiomyopathy (DCM) is a heart muscle disease of an undefined cause that commonly presents as congestive cardiac failure. The etiology of weakness of the heart muscle is often unknown, but many causal factors had been identified. Aim: This study aims to estimate the prevalence of DCM in heart failure patients in Dhamar Governorate, Yemen, and identify the risk factors associated with DCM among heart failure patients in Dhamar Governorate. Method: A prospective hospital-based observational study was undertaken during the period of 20 December 2021 to 20 January 2022 in two hospitals namely AL-Wahda Teaching Hospital and Taiba Consultative Hospital. After obtaining informed consent from the patients and their treating physicians, all patients diagnosed with heart failure were included in the study. A standardized questionnaire developed by the researcher was used to collect data on sociodemographic characteristics of patients; results of clinical, laboratory and radiography exams were recorded. Results: The prevalence of DCM among HF patients is 44%, which makes it the most common cause of heart failure. Ischemic heart disease follows as the second most common cause at 27%. Qat chewing was a major risk factor in 72%, HTN in 60%, smoking in 49%, DM in 32%, family history in 29%, and pregnancy in 2%. Male was affected more than female in 61%, and dyspnea was the most common presenting symptom in 96% of cases mostly (NYHA CLASS IV). Conclusion: This study about prevalence of DCM among HF patients registry for 100 cases (male, female), age group more than 16 years, duration from 20 December 2021 to 20 January 2022 in Al-Wahda Teaching Hospital and Taiba Consultative Hospital, Dhamar Governorate, Yemen. Our study findings show that DCM is the most prevalent cause of heart failure among all other causes, with a prevalence of 44%. Additionally, in our study, several risk factors were identified among the patients with heart failure, including chewing Qat, smoking, irregular treatment for diabetes, family history, and pregnancy.

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Al-Huthi, M. A. , Jayed, D. , Alshwki, S. , Mujlli, H. , Al-Dholae, M. and Almkdad, A. (2023). Prevalence and Risk Factors of Dilated Cardiomyopathy among Yemeni Patients with Heart Failure. Open Access Library Journal, 10, e9459. doi: http://dx.doi.org/10.4236/oalib.1109459.

References

[1]  Maron, B.J., Towbin, J.A., Theine, G., et al. (2006) Contemporary Definitions and Classification of the Cardiomyopathies: An American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation, 113, 1807-1816. https://doi.org/10.1161/CIRCULATIONAHA.106.174287
[2]  Elliott, P. andersson, B., Arbutin, E., et al. (2008) Classification of the Cardiomyopathies: A Position Statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. European Heart Journal, 29, 270-276. https://doi.org/10.1093/eurheartj/ehm342
[3]  Yancy, C.W., Jessup, M., Bozkurt, B., et al. (2013) 2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 62, 1495-1539. https://doi.org/10.1016/j.jacc.2013.05.020
[4]  Pinto, Y.M., Elliott, P.M., Arbutin, E., et al. (2016) Proposal for a Revised Definition of Dilated Cardiomyopathy, Hypokinetic Non-Dilated Cardiomyopathy, and Its Implications for Clinical Practice: A Position Statement of the ESC Working Group on Myocardial and Pericardial Diseases. European Heart Journal, 37, 1850-1858. https://doi.org/10.1093/eurheartj/ehv727
[5]  Manolios, T.A., Baughman, K.L., Roedeer, R., et al. (1992) Prevalence and Etiology of Idiopathic Dilated Cardiomyopathy (Summary of a National Heart, Lung, and Blood Institute Workshop). American Journal of Cardiology, 69, 1458-1466. https://doi.org/10.1016/0002-9149(92)90901-A
[6]  Taylor, M.R., Carnie, E. and Mastroeni, L. (2006) Cardiomyopathy, Familial Dilated. Orphanet Journal of Rare Diseases, 1, Article No. 27. https://doi.org/10.1186/1750-1172-1-27
[7]  Lipshultz, S., Sleeper, L., Tobin, J., et al. (2003) The Incidence of Pediatric Cardiomyopathy in Two Regions of the United States. The New England Journal of Medicine, 348, 1647-1655. https://doi.org/10.1056/NEJMoa021715
[8]  Nugent, A.W., Wilkinson, L.C., Dabney, P.E.F., et al. (2003) The Epidemiology of Childhood Cardiomyopathy in Australia. The New England Journal of Medicine, 348, 1639-1646. https://doi.org/10.1056/NEJMoa021737
[9]  Michel’s, V.V., Moll, P.P., Miller, F.A., et al. (1992) The Frequency of Familial Dilated Cardiomyopathy in a Series of Patients with Idiopathic Dilated Cardiomyopathy. The New England Journal of Medicine, 326, 77-82. https://doi.org/10.1056/NEJM199201093260201
[10]  Grundig, E., Tasman, J.A., Kucherov, H., Franz, W., Kubler, W. and Katsu, H.A. (1998) Frequency and Phenotypes of Familial Dilated Cardiomyopathy. Journal of the American College of Cardiology, 31, 186-194. https://doi.org/10.1016/S0735-1097(97)00434-8
[11]  Tobin, J.A., Lowe, A.M., Colin, S.D., et al. (2006) Incidence, Causes, and Outcomes of Dilated Cardiomyopathy in Children. JAMA, 296, 1867-1876. https://doi.org/10.1001/jama.296.15.1867
[12]  Hsu, D.T. and Canter, C.E. (2010) Dilated Cardiomyopathy and Heart Failure in Children. Heart Failure Clinics, 6, 415-432. https://doi.org/10.1016/j.hfc.2010.05.003
[13]  Pearson, G.D., Vielle, J.C., Kahtoola, S., et al. (2000) Peripartum Cardiomyopathy: National Heart, Lung, and Blood Institute and Office of Rare Diseases (National Institutes of Health) Workshop Recommendations and Review. JAMA, 283, 1183-1188. https://doi.org/10.1001/jama.283.9.1183
[14]  Hilfiger-Kleiner, D., Silwan, K. and Drexler, H. (2008) Peripartum Cardiomyopathy: Recent Insights in Its Pathophysiology. Trends in Cardiovascular Medicine, 18, 173-179. https://doi.org/10.1016/j.tcm.2008.05.002
[15]  Ware, J.S., Li, J., Malaika, E., et al. (2016) Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. The New England Journal of Medicine, 374, 233-241. https://doi.org/10.1056/NEJMoa1505517
[16]  Celta, F. and Michel’s, V.V. (1995) The Natural History and Spectrum of Idiopathic dilated Cardiomyopathy, Including HIV and Peripartum Cardiomyopathy. Current Opinion in Cardiology, 10, 332-338. https://doi.org/10.1097/00001573-199505000-00015
[17]  Maisch, B., Nutrias, M., Ruppert, V., Richter, A. and Panduit, S. (2012) Cardiomyopathies: Classification, Diagnosis, and Treatment. Heart Failure Clinics, 8, 53-78. https://doi.org/10.1016/j.hfc.2011.08.014
[18]  Lao Nigro, I., Correlate, M., Di Biased, M. and Alto mare, E. (2009) Alcohol Abuse and Heart Failure. European Journal of Heart Failure, 11, 453-462. https://doi.org/10.1093/eurjhf/hfp037
[19]  Fernandez-Sola, J. (2015) Cardiovascular Risks and Benefits of Moderate and Heavy Alcohol Consumption. Nature Reviews Cardiology, 12, 576-587. https://doi.org/10.1038/nrcardio.2015.91
[20]  Klosky, A.L. (2009) Alcohol and Cardiovascular Diseases. Expert Review of Cardiovascular Therapy, 7, 499-506. https://doi.org/10.1586/erc.09.22
[21]  Afonso, L., Mohammad, T. and Theta, D. (2007) Crack Whips the Heart: A Review of the Cardiovascular Toxicity of Cocaine. American Journal of Cardiology, 100, 1040-1043. https://doi.org/10.1016/j.amjcard.2007.04.049
[22]  Parritz, E.D., Cunningham, N.J. and MacIsaac, A.I. (2016) The Cardiac Complications of Methamphetamines. Heart, Lung and Circulation, 25, 325-332. https://doi.org/10.1016/j.hlc.2015.10.019
[23]  Yeo, K.K., Wijetunga, M., Ito, H., et al. (2007) The Association of Methamphetamine Use and Cardiomyopathy in Young Patients. The American Journal of Medicine, 120, 165-171. https://doi.org/10.1016/j.amjmed.2006.01.024
[24]  Schultz, S.E., Adams, M.J., Colin, S.D., et al. (2013) Long-Term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions: A Scientific Statement from the American Heart Association. Circulation, 128, 1927-1995. https://doi.org/10.1161/CIR.0b013e3182a88099
[25]  Lip Shultz, S.E., Lipsitz, S.R., Salla, S.E., et al. (2005) Chronic Progressive Cardiac Dysfunction Years after Doxorubicin Therapy for Childhood Acute Lymphoblastic Leukemia. Journal of Clinical Oncology, 23, 2629-2636. https://doi.org/10.1200/JCO.2005.12.121
[26]  Sorensen, K., Levitt, G.A., Bull, C., Droop, I. and Sullivan, I.D. (2003) Late Anthracycline Cardiotoxicity after Childhood Cancer: A Prospective Longitudinal Study. Cancer, 97, 1991-1998. https://doi.org/10.1002/cncr.11274
[27]  van der Pal, H.J., van Dalen, E.C., Hauptmann, M., et al. (2010) Cardiac Function in 5-Year Survivors of Childhood Cancer: A Long-Term Follow-Up Study. Archives of Internal Medicine, 170, 1247-1255. https://doi.org/10.1001/archinternmed.2010.233
[28]  van Dalen, E.C., van der Pal, H.J., Kook, W.E., Caron, H.N. and Kremer, L.C. (2006) Clinical Heart Failure in a Cohort of Children Treated with Anthracyclines: A Long-Term Follow-Up Study. European Journal of Cancer, 42, 3191-3198. https://doi.org/10.1016/j.ejca.2006.08.005
[29]  Lip Shultz, S.E., Rifai, N., Dalton, V.M., et al. (2004) The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia. The New England Journal of Medicine, 351, 145-153. https://doi.org/10.1056/NEJMoa035153
[30]  Cooper, L.T. (2009) Myocarditis. The New England Journal of Medicine, 360, 1526-1538. https://doi.org/10.1056/NEJMra0800028
[31]  Aretz, H.T., Billingham, M.E., Edwards, W.D., et al. (1987) Myocarditis. A Histopathologic Definition and Classification. The American Journal of Cardiovascular Pathology, 1, 3-14.
[32]  Chow, L.H., Radio, S.J., Sears, T.D. and McManus, B.M. (1989) Insensitivity of Right Ventricular Endomyocardial Biopsy in the Diagnosis of Myocarditis. Journal of the American College of Cardiology, 14, 915-920. https://doi.org/10.1016/0735-1097(89)90465-8
[33]  Baughman, K.L. (2006) Diagnosis of Myocarditis: Death of Dallas Criteria. Circulation, 113, 593-595. https://doi.org/10.1161/CIRCULATIONAHA.105.589663
[34]  Linderman, I., Linderman, M., Kandloff, R., et al. (2008) Predictors of Outcome in Patients with Suspected Myocarditis. Circulation, 118, 639-648. https://doi.org/10.1161/CIRCULATIONAHA.108.769489
[35]  Abdel-At, H., Boyes, P., Zagorsk, A., et al. (2005) Diagnostic Performance of Cardiovascular Magnetic Resonance in Patients with Suspected Acute Myocarditis: Comparison of Different Approaches. Journal of the American College of Cardiology, 45, 1815-1822. https://doi.org/10.1016/j.jacc.2004.11.069
[36]  Friedrich, M.G., Sachem, U., Schulz-Manger, J., et al. (2009) Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper. Journal of the American College of Cardiology, 53, 1475-1487. https://doi.org/10.1016/j.jacc.2009.02.007
[37]  Fabre, A. and Sheppard, M.N. (2006) Sudden Adult Death Syndrome and Other Non-Ischemic Causes of Sudden Cardiac Death. Heart, 92, 316-320. https://doi.org/10.1136/hrt.2004.045518
[38]  Ambrosio, A., Patti, G., Manzoni, A., et al. (2001) The Fate of Acute Myocarditis between Spontaneous Improvement and Evolution to Dilated Cardiomyopathy: A Review. Heart, 85, 499-504. https://doi.org/10.1136/heart.85.5.499
[39]  McCarthy, R.E., Boehmer, J.P., Aruban, R.H., et al. (2000) Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (No Fulminant) Myocarditis. The New England Journal of Medicine, 342, 690-695. https://doi.org/10.1056/NEJM200003093421003
[40]  Maisch, B. and Panduit, S. (2013) Standard and Etiology-Directed Evidence-Based Therapies in Myocarditis: State of the Art and Future Perspectives. Heart Failure Reviews, 18, 761-795. https://doi.org/10.1007/s10741-012-9362-7
[41]  Linderman, I., Barth, C., Mahfud, F., et al. (2012) Update on Myocarditis. Journal of the American College of Cardiology, 59, 779-792. https://doi.org/10.1016/j.jacc.2011.09.074
[42]  Kuhl, U., Bauschinger, M., Nutrias, M., et al. (2005) High Prevalence of Viral Genomes and Multiple Viral Infections in the Myocardium of Adults with “Idiopathic” Left Ventricular Dysfunction. Circulation, 111, 887-893. https://doi.org/10.1161/01.CIR.0000155616.07901.35
[43]  Dec, G.W. and Foster, V. (1994) Idiopathic Dilated Cardiomyopathy. The New England Journal of Medicine, 331, 1564-1575. https://doi.org/10.1056/NEJM199412083312307
[44]  Opie, L.H., Comerford, P.J., Gersh, B.J. and Pfeffer, M.A. (2006) Controversies in Ventricular Remodeling. The Lancet, 367, 356-367. https://doi.org/10.1016/S0140-6736(06)68074-4
[45]  Alter, P., Rupp, H., Stoll, F., et al. (2012) Increased End Diastolic Wall Stress Precedes Left Ventricular Hypertrophy in Dilative Heart Failure—Use of the Volume-Based Wall Stress Index. International Journal of Cardiology, 157, 233-238. https://doi.org/10.1016/j.ijcard.2011.07.092
[46]  Sayer, G. and Bhat, G. (2014) The Renin-Angiotensin-Aldosterone System and Heart Failure. Cardiology Clinic, 32, 21-32. https://doi.org/10.1016/j.ccl.2013.09.002
[47]  Bharuch, T., Lee, K.J., Dabney, P.E., et al. (2015) Sudden Death in Childhood Cardiomyopathy: Results from a Long-Term National Population-Based Study. Journal of the American College of Cardiology, 65, 2302-2310.
[48]  Lakdawala, N.K., Winterfield, J.R. and Funke, B.H. (2013) Dilated Cardiomyopathy. Circulation: Arrhythmia and Electrophysiology, 6, 228-237. https://doi.org/10.1161/CIRCEP.111.962050
[49]  McNair, W.P., Sinatra, G., Taylor, M.R., et al. (2011) SCN5A Mutations Associate with Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism. Journal of the American College of Cardiology, 57, 2160-2168. https://doi.org/10.1016/j.jacc.2010.09.084
[50]  Oromo, J., Kure, S., Shiba, T., et al. (2005) Electrophysiological and Histopathological Characteristics of Progressive Atrioventricular Block Accompanied by Familial Dilated Cardiomyopathy Caused by a Novel Mutation of Lamin A/C Gene. Journal of Cardiovascular Electrophysiology, 16, 137-145. https://doi.org/10.1046/j.1540-8167.2004.40096.x
[51]  Friedrich, M.G. and Marcotte, F. (2013) Cardiac Magnetic Resonance Assessment of Myocarditis. Circulation: Cardiovascular Imaging, 6, 833-839. https://doi.org/10.1161/CIRCIMAGING.113.000416
[52]  Marold, H., Boedecker, C., Wagner, A., et al. (2004) Cardiovascular Magnetic Resonance Assessment of Human Myocarditis: A Comparison to Histology and Molecular Pathology. Circulation, 109, 1250-1258. https://doi.org/10.1161/01.CIR.0000118493.13323.81
[53]  Gyotakus, N., Kigali, M., Stephens, D., Dawson, D., Muntons, F. and Muntons, P. (2006) Cardiac Tissue Velocities and Strain Rate in the Early Detection of Myocardial Dysfunction of Asymptomatic Boys with Duchenne’s Muscular Dystrophy: Relationship to Clinical Outcome. Heart, 92, 840-842. https://doi.org/10.1136/hrt.2005.067710
[54]  Ashford, M.W., Liu, W., Lin, S.J., et al. (2005) Occult Cardiac Contractile Dysfunction in Dystrophin-Deficient Children Revealed by Cardiac Magnetic Resonance Strain Imaging. Circulation, 112, 2462-2467. https://doi.org/10.1161/CIRCULATIONAHA.104.516716
[55]  Dubuc, D., Mesne, C., Ledebur’s, G., Decaux, J.Y., Waksman, G. and Became, H.M. (2005) Effect of Perindopril on the Onset and Progression of Left Ventricular Dysfunction in Duchenne Muscular Dystrophy. Journal of the American College of Cardiology, 45, 855-857. https://doi.org/10.1016/j.jacc.2004.09.078
[56]  Cooper, L.T., Baughman, K.L., Feldman, A.M., et al. (2007) The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease: A Scientific Statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology. Journal of the American College of Cardiology, 50, 1914-1931.
[57]  Kirk, R., Dip Chand, A.I., Rosenthal, D.N., et al. (2014) The International Society for Heart and Lung Transplantation Guidelines for the Management of Pediatric Heart Failure: Executive Summary. The Journal of Heart and Lung Transplantation, 33, 888-909. https://doi.org/10.1016/j.healun.2014.06.002
[58]  Ichida, F., Hanamachi, Y., Miyawaki, T., et al. (1999) Clinical Features of Isolated Noncompaction of the Ventricular Myocardium: Long-Term Clinical Course, Hemodynamic Properties, and Genetic Background. Journal of the American College of Cardiology, 34, 233-240. https://doi.org/10.1016/S0735-1097(99)00170-9
[59]  Richardson, P., McKenna, W., Bristow, M., et al. (1996) Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies. Circulation, 93, 841-842. https://doi.org/10.1161/01.CIR.93.5.841
[60]  Baffa, G.M., Theine, G., Nava, A. and Dalla Volta, S. (1991) Cardiomyopathy: A Necessary Revision of the WHO Classification. International Journal of Cardiology Jan, 30, 1-7. https://doi.org/10.1016/0167-5273(91)90117-8
[61]  Gillum, R.F. (1986) Idiopathic Cardiomyopathy in the United States, 1970-1982. American Heart Journal, 111, 752-755. https://doi.org/10.1016/0002-8703(86)90111-0
[62]  Codd, M.B., Sugrue, D.D. and Gersh, B.J. (1989) Epidemiology of Idiopathic Dilated and Hypertrophic Cardiomyopathy. A Population-Based Study in Olmsted County, Minnesota, 1975-1984. Circulation, 80, 564-572. https://doi.org/10.1161/01.CIR.80.3.564
[63]  Codd, M.B., Sugrue, D.D., Gersh, B.J. and Melton 3rd, L.J. (1989) A Population-Based Study in Olmsted County, Minnesota, 1975-1984. Circulation, 80, 564-572. https://doi.org/10.1161/01.CIR.80.3.564

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