Background: Jatropha curcas belongs to the Euphorbiaceae family and is found in the coastal areas of tropics. The leaves, fruits and seeds of the plant are used for various ailments. Not only there are few reported cases of its poisoning in the paediatric age group but also rarely reported to cause neurological manifestation even in adult population. We present a case of a 5 years old that presented with severe acute neurological manifestation soon after ingestion of the seeds of Jatropha curcas. The patient was managed symptomatic and supportive with complete recovery in 48 hrs. Case Presentation: 5 years old male child was referred to our hospital 7 hrs after taking Jatropha curcas fruit. He presented with history of loss of consciousness for 2 hours and 3 episodes of convulsions. On examination had Glasgow Coma Score (GCS) of 8/15, and pinpointed pupils, with no obvious neurological deficit. We managed him conservatively, with active seizure control, IV fluid, and precautious IV Ceftriaxone due to clinical mimicry of meningitis. The patient completely recovered and was discharged on the third day. Conclusion: Jatropha curcas poisoning is less reported in our region and our country. Based on our case report, it does not only present with gastrointestinal manifestation but also neurological manifestation which may be confusing in low resource setting where the diagnostics may not be available or affordable to rule out other intracranial manifestations due to low social economic status. This is the first case report in our setup and country with neurological manifestation.
Cite this paper
Mselle, M. , Shayo, A. , Mbwasi, R. , Mrindoko, P. , Kimambo, E. , Likiliwike, A. , Frisch, L. , Meleki, E. , Hatibu, Z. , Peter, N. , Iman, A. , Mosha, F. , Maringo, B. , Minga, I. and Mchaile, D. (2022). Severe Neurological Manifestation from Jatropha curcas (Mbono Kaburi) Poisoning in 5 Years Old: A Case Report. Open Access Library Journal, 9, e8028. doi: http://dx.doi.org/10.4236/oalib.1108028.
Barceloux, D.G. (2008) Barbados Nut (Jatropha curcas L.) Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants and Venomous Animals. John Wiley & Sons Inc., Hoboken, Chapter 140.
Marks, C.J. and van Hoving, D.J. (2016) A 3-Year Survey of Acute Poisoning Exposures in Infants Reported in Telephone Calls Made to the Tygerberg Poison Information Centre, South Africa. South African Journal of Child Health, 10, 43-46.
https://doi.org/10.7196/SAJCH.2016.v10i1.1045
Mampane, K.J., Joubert, P.H. and Hay, I.T. (1987) Jatropha curcas: Use as a Traditional Tswana Medicine and Its Role as a Cause of Acute Poisoning. Pharmacological Research, 1, 50-51. https://doi.org/10.1002/ptr.2650010112
Wanzala, W. and Wanjala, C.C.W. (2016) Discovering Poisonous Plants by Tasting: The Case of Children in Mumias Sub-County, Kenya. Arabian Journal of Medicinal and Aromatic Plants, 2, 99-110.
Pocock, S.J., Collier, T.J., Dandreo, K.J., et al. (2004) Issues in the Reporting of Epidemiological Studies: A Survey of Recent Practice. BMJ, 329, 880-883.
https://doi.org/10.1136/bmj.38250.571088.55
Kosam, A. and Nahrel, R. (2014) Clinical Profile of Jatropha curcas Poisoning in Children. International Journal of Medical Research and Review, 2, 221-227.
https://doi.org/10.17511/ijmrr.2014.i03.12
Levin, Y., Sherer, Y., Bibi, H., Schlesinger, M. and Hay, E. (2000) Rare Jatropha multifida Intoxication in Two Children. Journal of Emergency Medicine, 19, 173-175.
https://doi.org/10.1016/S0736-4679(00)00207-9
Ribeiro, S.S., et al. (2012) Chemical Constituents of Methanolic Extracts of Jatropha curcas L and Effects on Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae). Química Nova, 35, 2218-2221.
https://doi.org/10.1590/S0100-40422012001100022
Alexander, Z.-H., Rommel, Z.-H., Sergio, G.-L., Ernesto, Z.-F., Jorge, G.-B., Angel, C.-S., Carlos, P.-M. and Granara, A.A. (2016) Study on Inflammation and the Nervous System of Ethanol Extract of Jatropha curcas Seed. Pharmacognosy Journal, 8, 335-340. https://doi.org/10.5530/pj.2016.4.5
Langrand, J., Médernach, C., Schmitt, C., Blanc-Brisset, I., Villa, A.F., de Haro, L. and Garnier, R. (2015) Intoxications par pignons d’Inde (Jatropha curcas): 24 observations rapportées aux centres antipoison de Paris et Marseille [Poisoning with Jatropha curcas: 24 Cases Reported to Paris and Marseille Poisons Centers]. Bulletin de la Société de Pathologie Exotique, 108, 139-143.
https://doi.org/10.1007/s13149-014-0412-3
Koltin, D., Uziel, Y., Schneidermann, D., Kotzki, S., Wolach, B. and Fainmesser, P. (2006) A Case of Jatropha multifida Poisoning Resembling Organophosphate Intoxication. Clinical Toxicology (Philadelphia, Pa.), 44, 337-338.
https://doi.org/10.1080/15563650600584584
Singh, R.K., Singh, D. and Mahendrakar, A.G. (2010) Jatropha Poisoning in Children. Medical Journal Armed Forces India, 66, 80-81.
https://doi.org/10.1016/S0377-1237(10)80106-6