Primary breast lymphoma (PBL) is considered a rare clinical entity, representing approximately 0.4% to 0.5% of all breast tumors. In this report, we present a case of Primary breast lymphoma in a 19-year-old woman complaining of a lump in the right breast and a nodule in the left breast. Breast imaging pointed towards PBL which was confirmed by the results of immunohistochemistry. The case was eventually diagnosed as non-Hodgkin’s type B lymphoma. The management of PBL and carcinomas is completely different. The value of preoperative diagnosis should be emphasized, as the patient avoids unnecessary surgery and begins chemotherapy earlier.
Cite this paper
Asmouki, H. , Elmahfoudi, A. , Fakhir, B. , Aboulfalah, A. and Soumani, A. (2020). Primary Bilateral Malignant Non-Hodgkin’s Lymphoma of the Breast: A Case Report and Review of the Literature. Open Access Library Journal, 7, e6099. doi: http://dx.doi.org/10.4236/oalib.1106099.
Harb, O.A., Balata, S.A., Ashour, H., Eltokhy, E., Gertallah, L.M., Ahmed, R.Z. and Hassanin, A.M. (2019) Primary Diffuse Large B-Cell Non-Hodgkin’s Lymphoma of the Breast: A Case Report and Review of the Literature. Radiology Case Reports, 14, 22-27. https://doi.org/10.1016/j.radcr.2018.09.004
Gupta, V., Bhutani, N., Singh, S., Chhabra, S. and Sen, R. (2017) Primary Non-Hodgkin’s Lymphoma of Breast—A Rare Cause of Breast Lump. Human Pathology: Case Reports, 7, 47-50. https://doi.org/10.1016/j.ehpc.2016.07.004
Marinopoulosa, S., Safioleasa, P., Skordab, L., Vassilopouloua, E., Zagouric, F., Sotiropouloud, M., Drakakisa, P. and Dimitrakakisa, C. (2017) Breast Lymphoma in a Patient with B-Cell Non Hodgkin Lymphoma: A Case Report Study. International Journal of Surgery Case Reports, 40, 1-5. https://doi.org/10.1016/j.ijscr.2017.09.003
Agha, R.A., Fowler, A.J., Saetta, A., Barai, I., Rajmohan, S., Orgill, D.P. and the SCARE Group (2016) The SCARE Statement: Consensus-Based Surgical Case Report Guidelines. International Journal of Surgery, 34, 180-186.
Yang, H., Lang, R.-G. and Fu, L. (2011) Primary Breast Lymphoma (PBL): A Literature Review. Clinical Oncology and Cancer Research, 8, 128-132. https://doi.org/10.1007/s11805-011-0570-z
Sabate, J.M., Gomez, A., Torruba, S., Camins, A., Roson, N., De Las Heras, P., et al. (2002) Lymphoma of the Breast: Clinical and Radiological Features with Pathologic Correlation in 28 Patients. The Breast Journal, 8, 294-304. https://doi.org/10.1046/j.1524-4741.2002.08509.x
Ganjoo, K., Advani, R., Mariappan, M.R., McMillan, A. and Horning, S. (2007) Non-Hodgkin Lymphoma of the Breast. Cancer, 110, 25-30. https://doi.org/10.1002/cncr.22753
Wadhwa, A. and Senebouttarath, K. (2018) Primary Lymphoma of the Breast: A Case Series. Radiology Case Reports, 13, 815-821. https://doi.org/10.1016/j.radcr.2018.04.009
Surov, A., Holzhausen, H.J., Wienke, A., Schmidt, J., Thomssen, C., Arnold, D., Ruschke, K. and Spielmann, R.P. (2012) Primary and Secondary Breast Lymphoma: Prevalence, Clinical Signs and Radiological Features. British Journal of Radiology, 85, e195-e205. https://doi.org/10.1259/bjr/78413721
Stanton, M.P., Cutress, R. and Royle, G.T. (2000) Primary Non-Hodgkin’s Lymphoma of the Female Breast Masquerading as a Breast Abscess. European Journal of Surgical Oncology, 26, 429. https://doi.org/10.1053/ejso.1999.0912
Grubstein, A., Givon-Madhala, O., Morgenstern, S. and Cohen, M. (2005) Extranodal Primary B-Cell Non-Hodgkin Lymphoma of the Breast Mimicking Acute Mastitis. Journal of Clinical Ultrasound, 33, 140-142. https://doi.org/10.1002/jcu.20101
Jabbour, G., El-Mabrok, G., Al-Thani, H., El-Menyar, A., Al-Hijji, I. and Napaki, S. (2016) Primary Breast Lymphoma in a Woman: A Case Report and Review of the Literature. American Journal of Case Reports, 17, 97-103. https://doi.org/10.12659/AJCR.896264
Aviv, A., Tadmor, T. and Polliack, A. (2013) Primary Diffuse Large B-Cell Lymphoma of the Breast: Looking at Pathogenesis, Clinical Issues and Therapeutic Options. Annals of Oncology, 24, 2236-2244. https://doi.org/10.1093/annonc/mdt192
Wong, W.W., Schild, S.E., Halyard, M.Y. and Schomberg, P.J. (2002) Primary Non-Hodgkin Lymphoma of the Breast: The Mayo Clinic Experience. Journal of Surgical Oncology, 80, 19-25. https://doi.org/10.1002/jso.10084
Park, Y.H., Kim, S.H., Choi, S.J., et al. (2004) Primary Malignant Lymphoma of the Breast: Clinicopathological Study of Nine Cases. Leukemia & Lymphoma, 5, 327-330. https://doi.org/10.1080/10428190310001597892
Misra, A., Kapur, B.M. and Rath, G.K. (1991) Primary Breast Lymphoma. Journal of Surgical Oncology, 47, 265-270. https://doi.org/10.1002/jso.2930470412
