Malaria is one of the major causes of disease for people living in tropical and subtropical areas. Blood coagulation activation is frequently found in patients with malaria. The aim of the current study is to assess prothrombin time, activated partial thromboplastin time and D-dimer in patient suffering from malaria. This study includes 50 patients who have malaria parasite and 50 persons as control. Sandwich chemiluminescence immunoassay uses ABEI to label an anti-D-dimer monoclonal antibody and uses another D-dimer monoclonal antibody to coat magnetic microbeads. Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) were measured for all case and control and SPSS software was used to evaluate the correlation. Results of D-dimer in all patient in mean were 1.92 ± 1.09 ng/ml; the D-dimer level was significantly higher among patients (p value = 0.00) compared to control (0.41 ± 0.10 ng/ml). PT in patient in mean was 16.34 ± 2.67 seconds and the mean of PT result in control was 14.29 ± 0.92 seconds; the mean of INR results in patients was 1.22 and the mean of INR results in control was 1.19. The results of PTT in patients in mean were (30.40 ± 4.73 second) and the mean of PTT results in control were (27.82 ± 1.49 seconds). Also, our result shows no statistically significant in PT, APTT and D-dimer between male and female. In conclusion, our study revealed higher D-dimer levels, PT and APTT among patient with Malaria, while the gender showed no effect on the level of D-dimer levels, PT and APTT.
Cite this paper
Mohammed, O. I. A. and Abdalla, M. H. A. (2019). Determination of Prothrombin Time, Activated Partial Thromboplastin Time and D-Dimer Levels among Malaria Infected Patients in Sinnar State, Sudan. Open Access Library Journal, 6, e5975. doi: http://dx.doi.org/10.4236/oalib.1105975.
Tangpukdee, N., Duangdee, C., Wilairatana, P. and Krudsood, S. (2009) Malaria Diagnosis: A Brief Review. The Korean Journal of Parasitology, 47, 93-102. https://doi.org/10.3347/kjp.2009.47.2.93
L?mmle, B. and Griffin, J.H. (1985) Formation of the Fibrin Clot: The Balance of Procoagulant and Inhibitory Factors. Clinics in Haematology, 14, 281-342.
Ali, N.M., Gameel, F.E., Elsayid, M. and Babker, A.M. (2016) Alterations in D-Dimer, Prothrombin Time and Activated Partial Thromboplastin Time as Thrombogenesis Activity Markers in Patients with Acute Myocardial Infarction. Open Journal of Blood Diseases, 6, 1-5. https://doi.org/10.4236/ojbd.2016.61001
Mohamed, A.O., Hamza, K.M. and Babker, A.M. (2016) Physiological Changes in Some Hematological and Coagulation Profile among Sudanese Healthy Pregnant Women. International Journal of Medical Science and Public Health, 5, 525-528. https://doi.org/10.5455/ijmsph.2016.30092015149
Prasad, R., Das, B.K., Pengoria, R., Mishra, O.P., Shukla, J. and Singh, T.B. (2009) Coagulation Status and Platelet Functions in Children with Severe Falciparum Malaria and their Correlation of Outcome. Journal of Tropical Pediatrics, 55, 374-378. https://doi.org/10.1093/tropej/fmp028
Babker, A.M. and Gameel, F.E. (2014) The Frequency of Factor V Leiden Mutation among Sudanese Pregnant Women with Recurrent Miscarriage. Journal of American Science, 10, 63-66.
Awad-Elkareem, A., Elzaki, S.G., Khalid, H., Abdallah, M.S. and Adam, I. (2017) A Low Rate of Factor V Leiden Mutation among Sudanese Women with Deep Venous Thrombosis during Pregnancy and Puerperium. Journal of Obstetrics and Gynaecology, 37, 963-964. https://doi.org/10.1080/01443615.2017.1306033
Babker, A.M. and Gameel, F.E. (2015) Molecular Characterization of Prothrombin G20210A Gene Mutations in Pregnant Sudanese Women with Spontaneous Recurrent Abortions. Rawal Medical Journal, 40, 207-209.
Phillips, R.E. and Looareesuwan, S. (1986) Importance of Anaemia in Cerebral and Uncomplicated Falciparum Malaria. Quarterly Journal of Medicine, 227, 305-323.
Rojanasthein, S. and Boonpucknavig, S. (1991) Haematological and Coagulation Studies in Malaria. Journal of the Medical Association of Thailand, 75, 190-195.
Eldour, A.A.A., Khalafallah, T.O., Noja, H.M., Saad, E.S.M., Elsayid, M. and Allah Babker, A.M.A. (2016) Fibrinogen Levels in Hypertensive and Normotensive: A Cross-Sectional Study from El-Obied City, Sudan. Journal of Biosciences and Medicines, 4, 28-32. https://doi.org/10.4236/jbm.2016.42004
Das, S., Datta, S., Roul, L.D., Panda, J.K., Pattanayak, N.C. and Bhattacherjee, S. (2011) A Study of the Coagulation Profile in Falciparum Malaria. Orissa Physicians Journal, 7, 7-12.
Abdabagi, S.M., Altayeb, F.M., Alla, A.B., Alrhaman Osman, R.A. and Nasir, A.E. (2018) Evaluation the Effect of the Malaria Parasite on Prothrombin Time and Activated Partial Thromboplastin Time Levels among Sudanese Patient in Khartoum State-Sudan. International Journal of Advanced Research, 6, 1045-1049. https://doi.org/10.21474/IJAR01/7769
Mustafa, M.E., Mansoor, M.M., Mohammed, A. and Babker, A.A. (2015) Evaluation of Platelets Count and Coagulation Parameters among Patients with Liver Disease. World Journal of Pharmaceutical Research, 4, 360-368.