All Title Author
Keywords Abstract

Topic: Echocardiographic Evaluation of Left Ventricular Systolic and Diastolic Function in Nigerians with Sickle Cell Disease

DOI: 10.4236/oalib.1104527, PP. 1-8

Subject Areas: Cardiology

Keywords: Left Ventricular Systolic Function, Left Ventricular Diastolic Function, Sickle Cell Disease, Nigerians

Full-Text   Cite this paper   Add to My Lib


Introduction: Sickle cell disease (SCD) is chronic, inherited haemoglobin disorder, associated with chronic tissue ischemia which may adversely affect any organ system. Chronic anaemia in SCD results in cardiac chamber dilatation with compensatory increase in left ventricular mass and varying degree of diastolic dysfunction that has been a strong independent predictor of mortality in patients with SCD. There is paucity of echocardiographic studies on adults Nigerians with SCD. This study therefore, aimed to assess left ventricular systolic and diastolic function among sickle cell disease patients in Kano State, North-Western Nigeria. Methods: The study was cross-sectional and comparative conducted at the SCD clinic and Medical/outpatient (MOP) clinic of Murtala Muhammad Specialist Hospital (MMSH), on eligible patients aged 13 years and above. One hundred patients with SCD (HbSS) were recruited as the study group while 100 non SCD (HbAA) patients, matched for age and sex served as controls. Left and right atrial and ventricular dimensions, left ventricular (LV) wall thickness, LV mass index and LV contractility variables were obtained. Parameters of LV diastolic function were also evaluated. Results: There were increases in the left atrial and left ventricular dimensions, left ventricular volumes and left ventricular mass (LVM) of the SCD patients. LV ejection fraction was equivalent, though there was evidence of left ventricular diastolic dysfunction in up to 36%. Conclusion: Left ventricular diastolic dysfunction may complicate cases adults with SCD.

Cite this paper

Saidu, H. , Kabir, A. , Yau, J. A. , Yakasai, A. M. , Abdullahi, U. , Nalado, A. M. and Musa, B. M. (2018). Topic: Echocardiographic Evaluation of Left Ventricular Systolic and Diastolic Function in Nigerians with Sickle Cell Disease. Open Access Library Journal, 5, e4527. doi:


[1]  Platt, O.A., Brambilla, D.J., Rosse, W.F., et al. (1994) Mortality in Sickle Cell Disease, Life Expectancy and Risk Factors for Early Death. The New England Journal of Medicine, 330, 1639-1644.
[2]  Lester, L.A., Sodt, P.C., Hutcheon, N. and Archilla, R.A. (1990) Cardiac Abnormalities in Children with Sickle Cell Anaemia. Chest, 98, 1169-1174.
[3]  Grossman, W., Jones, D. and McLaurin, L.P. (1975) Wall Stress and Patterns of Hypertrophy in the Human Left Ventricle. Journal of Clinical Investigation, 56, 56-64.
[4]  Sachdev, V., Machado, R.F. and Shizukuda, Y. (2007) Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients with Sickle Cell Disease. Journal of the American College of Cardiology, 49, 472-479.
[5]  Covitz, W., Espeland, M., Gallagher, D., Hellenbrand, W., Leff, S. and Talner, N. (1995) The Heart in Sickle Cell Anaemia. The Cooperative Study of Sickle Cell Disease (CSSCD). Chest, 108, 1214-1219.
[6]  Dham, N., Ensing, G., Minniti, C., et al. (2009) Prospective Echocardiography Assessment of Pulmonary Hypertension and Its Potential Etiologies in Children with Sickle Cell Disease. American Journal of Cardiology, 104, 713-720.
[7]  (2002) World Medical Association Declaration of Helsinki, Ethical principles for Medical Research involving Human Subjects. Journal of Postgraduate Medicine, 48, 206-208.
[8]  American Society of Hypertension (1992) Recommendations for Routine Blood Pressure Measurement by Indirect Cuff Sphygmomanometry. American Journal of Hypertension, 5, 207-209.
[9]  Sahn, D.J., De Maria, A., Kisslo, J. and Weyman, A. (1978) Recommendations Regarding Quantitation in the M-Mode Echocardiography. Results of the Survey of Echocardiographic Measurements. Circulation, 56, 1072-1083.
[10]  Roelandt, J. and Gibson, D.G. (1980) Recommendations for Standardization of Measurements from M-Mode Electrocardiogram. European Heart Journal, 5, 375-378.
[11]  Teichholz, L.E., Kreulen, T. and Herman, M.V. (1976) Problems in Echocardiographic Volume Determinations: Echocardiographic-Angiographic Correlations in the Presence or Absence of Synergy. American Journal of Cardiology, 37, 7-11.
[12]  Oh, J.K., Seward, J.B. and Taofik, A.J., Eds. (2006) Goal Directed and Comprehensive Examination. In the Echo Manual, 3rd Edition, 390-340.
[13]  Bamigboye-Taiwo, O.T., Okeniyi, J.A., Omokhodion, S.I., Adeodu, O.O. and Elusiyan, J.B. Cardiac Dimensions and Functional Parameters in Nigerian Children with Homozygous Sickle Cell Anaemia Using Echocardiography. Journal of Clinical & Experimental Cardiology, 6, 368.
[14]  Lindsay Jr., J., Meshel, J.C. and Patterson, R.H. (1974) The Cardiovascular Manifestations of Sickle Cell Disease. Archives of Internal Medicine, 133, 643-651.
[15]  Gerry, J.L., Joseph, L., Bernadine, H., Grover, H. and Hutchins, M.D. (1978) Clinicopathologic Analysis of Cardiac Dysfunction in 52 Patients with Sickle Cell Anaemia. American Journal of Cardiology, 42, 211-216.
[16]  Abdul-Mohsen, M.F. (2012) Echocardiographic Evaluation of Left Ventricular Diastolic and Systolic Dysfunction in Saudi Patients with Sickle Cell Disease. Journal of the Saudi Heart Association, 24, 217-224.
[17]  Hankins, J.S., McCarville, B., Hillebrand, C.M., Loeffler, R.B., Ware, R.E. and Song, R. (2010) Pediatr Blood Cancer, 55, 495-500.
[18]  Snider, A.R., Serwer, G.A. and Ritter, S.B., Eds. (1997) Echocardiography in Paediatric Heart Disease. Mosby, St. Louis, 596.
[19]  Balfour, I.C., Covitz, W., Arensman, F.W., Eubig, C., Garrido, M. and Jones, C. (1988) Left Ventricular Filling in Sickle Cell Anaemia. The American Journal of Cardiology, 61, 395-399.
[20]  Zilverman, M.V., Wei, D.U., Srikant, D. and Sharada, A.S. (2007) Evaluation of Left Ventricular Diastolic Function in Paediatric Sickle Cell Disease Patients. American Journal of Hematology, 82, 433-438.
[21]  Rodgers, G.P., Walker, E.C. and Podgor, M.J. (1993) Is “Relative” Hypertension a Risk Factor for Vaso-Occlusive Complications in Sickle Cell Disease? The American Journal of the Medical Sciences, 305, 150-156.
[22]  Mureddu, G.F., De Simone, G., Greco, R., Rosato, G.F. and Contaldo, F. (1996) Left Ventricular Filling Pattern in Uncomplicated Obesity. The American Journal of Cardiology, 77, 509-514.
[23]  Yamamoto, K., Wilson, D.J., Canzanello, V.J. and Redfieild, M.M. (2000) Left Ventricular Diastolic Dysfunction in Patients with Hypertension and Preserved Systolic Function. Mayo Clinic Proceedings, 75, 148-155.
[24]  Koga, S., Ikeda, S., Matsunaga, K., Naito, T., Miyahara, Y., Taura, K. and Kohno, S. (2003) Influence of Hemodialysis on Echocardiographic Doppler Indices of the Left Ventricle: Changes in Parameters of Systolic and Diastolic Function and Tei Index. Clinical Nephrology, 59, 180-185.


comments powered by Disqus