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Evaluation of Cardiovascular Risk Factors in Tunisian Coronary Patients

DOI: 10.4236/oalib.1104214, PP. 1-11

Subject Areas: Cardiology

Keywords: Acute Coronary Syndrome, Cardiovascular Risk Factors, Homocysteine, Methylenetetrahydrofolate Reductase, C677T Polymorphism

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Introduction: Ischemic heart disease ranked among the leading causes of death worldwide. Several biological and genetic risk factors associated with acute coronary syndrome. By addressing the risk factors, it is possible to prevent most of the cardiovascular diseases and contribute to the reduction of complications of acute coronary syndrome. Material and Methods: Our study is a prospective study that was conducted to the main military hospital of instruction of Tunis. Recruitment involved 122 coronary (n = 122) and 705 controls (n = 705) totaling a population of 827 subjects. Data collection concerned socio-demographic characteristics, anthropometric measurements, habits and lifestyle, health status and biological assessment. Results: Our study reported a high prevalence of cardiovascular classic risk factor particularly overweight (62.3%), diabetes (63.1%) and hypertension (50%). In 55% of coronary patients, moderate to intermediate hyperhomocysteinemia was found, but it appears to be an independent risk factor. The results of our study show a significant difference in the genotypic frequencies of the C677T mutation in the MTHFR gene between the two populations, cases and controls. Conclusion: Acute coronary syndromes are the leading cause of sudden death in adults. The evaluation of risk factors after acute coronary syndrome episode is essential for a better management according to the recommendations of learned societies and standards of good practice.

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Nadra, G. , Rihab, S. , Ossama, L. , Sana, A. , Manel, A. , Mabrouka, E. O. , Najla, S. , Thaker, L. , Habib, H. , Chakib, M. and Zied, A. (2018). Evaluation of Cardiovascular Risk Factors in Tunisian Coronary Patients. Open Access Library Journal, 5, e4214. doi:


[1]  Haute Autorité de Santé (2007) Les Syndromes Coronaires aigus (SCA). HAS, Paris.
[2]  World Health Organization (2015) Main Causes of Death in the World.
[3]  World Health Organization (2015) Cardiovascular Diseases.
[4]  Ministry of Health (2011) The State of Health of the Population in France. Follow-Up of the Objectives Annexed to the Public Health Law. Ministry of Health, Paris.
[5]  Bermudez, E.A., Rifai, N., Buring, J., Manson, J.E. and Ridker, P.M. (2002) Interrelationships among Circulating Interleukin-6, C-Reactive Protein, and Traditional Cardiovascular Risk Factors in Women. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 1668-1673.
[6]  Lerner, D.J. and Kannel, W.B. (1986) Patterns of Coronary Heart Disease Morbidity and Mortality in the Sexes: A 26-Year Follow-Up of the Framingham Population. American Heart Journal, 111, 383-390.
[7]  Chambless, L., Keil, U., Dobson, A., Mahonen, M., Kuulasmaa, K., Rajakangas, A.M., et al. (1997) Population versus Clinical View of Case Fatality from Acute Coronary Heart Disease: Results from the WHO MONICA Project 1985-1990. Multinational Monitoring of Trends and Determinants in Cardiovascular Disease. Circulation, 96, 3849-3859.
[8]  Leclercq, F. (2010) Is the Coronary Disease of Women Particular? La Presse Médicale, 39, 242-248.
[9]  Seck, M., Diouf, I., Acouetey, L., Wade, K.A., Thiam, M. and Diatta, B. (2007) Profile of Patients Admitted for Myocardial Infarction at the Emergency Department of the Dakar Main Hospital. Medecine Tropicale, 67, 569-572.
[10]  Scheen, A.J. (2004) How I Explore Absolute Cardiovascular Risk at Age 10: From Framingham 1998 to SCORE 2003. Revue Medicale De Liege, 59, 460-466.
[11]  Lihioui, M., Boughzala, E., Benferhat, E., Ammar, H., Chaouche, A., Jemaa, R., et al. (2007) Distribution of Cardiovascular Risk Factors in Coronary Patients in the Tunisian Sahel. Eastern Mediterranean Health Journal, 13, 536-542.
[12]  Elasmi, M., Feki, M., Sanhaji, H., Jemaa, R., Haj Taeib, S., Omar, S., et al. (2009) Prevalence of Conventional Cardiovascular Risk Factors in the Population of Greater Tunis. Revue d’Epidémiologie et de Santé Publique, 57, 87-92.
[13]  Yusuf, S., Hawken, S. and Ounpuu, S. (2004) Effect of Potentially Modifiable Risk Factors Associated with Myocardial Infarction in 52 Countries (the INTERHEART Study): Case-Control Study. Lancet, 364, 937-952.
[14]  Sultan, A. (2014) Coronary Risk Associated with Overweight and Obesity: No Need for Metabolic Syndrome. Endocrinology, Diabetes, & Metabolism, 8, 16-17.
[15]  Bogers, R.P., Bemelmans, W.J.E., Hoogenveen, R.T., Boshuizen, H.C., Woodward, M., Knekt, P., et al. (2007) Association of Overweight with Increased Risk of Coronary Heart Disease Partly Independent of Blood Pressure and Cholesterol Levels: A Meta-Analysis of 21 Cohort Studies Including More than 300 000 Persons. Archives of Internal Medicine, 167, 1720-1728.
[16]  Yano, Y., Kario, K., Ishikawa, S., Ojima, T., Gotoh, T., Kayaba, K., et al. (2013) Associations between Diabetes, Leanness, and the Risk of Death in the Japanese General Population. Diabetes Care, 36, 1186-1192.
[17]  Ben Salem, H., Ouali, S., Hammasa, S., Bougmizab, I., Gribaa, R., Ghannem, K., et al. (2011) Influence of Diabetes Mellitus on the Prognosis of Acute Coronary Syndromes without ST Addiction. Annales de Cardiologie et d’Angeiologie, 60, 33-38.
[18]  Merzouk, F., Bendriss, L. and Khatouri, A. (2013) Acute Coronary Syndrome and Type 2 Diabetes: A Study of 244 Cases. Diabetes & Metabolism, 39, A118.
[19]  Ben Alaya, N., Ben Romdhane, H. and Delpeuch, F. (2002) Causal Model of Ischemic Heart Disease in Tunisia. In: Sahar, A.Y. and The Bihan, G., Eds., The Causal Approach Applied to Food and Nutritional Surveillance in Tunisia, CIHEAM, Montpellier, 95-118.
[20]  Wang, J., Zhang, L., Wang, F., Liu, L. and Wang, H. (2014) Prevalence, Awareness, Treatment, and Control of Hypertension in China: Results from a National Survey. American Journal of Hypertension, 27, 1355-1361.
[21]  Pibarot, P.H., Lemieux, I. and Després, J.P. (2011) Metabolic Syndrome: A Challenge of Size. Joint Health Care, 24, 65-68.
[22]  Baligadoo, S. (2012) High Coronary Mortality in Mauritius. Study of Risk Factors and Genomic Analyzes. Bulletin de L’Académie Nationale de Médecine, 196, 1381-1396.
[23]  Guinchard-Foulon, E., Rodriguez-Lafrasse, C. and Rousson, R. (2013) HDL-Cholesterol: Place of Its Dosage in the Evaluation of a Cardiovascular Risk. Annales De Biologie Clinique, 61, 549-556.
[24]  Erqou, S., Kaptoge, S., Perry, P.L., Di Angelantonio, E., Thompson, A., White, I.R., et al. (2010) Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular Mortality. The Journal of the American Medical Association, 302, 412-423.
[25]  Belkahla, R., Omezzine, A., Kchok, K., Rebhi, L., Ben Hadj Mbarek, I., Rejeb, J., et al. (2010) Effect of Polymorphisms of Key Enzymes of Homocysteine Metabolism on Homocysteinemia and Coronary Risk in a Tunisian Population. Annales de Cardiologie et d’Angeiologie, 57, 219-224.
[26]  Booth, G.L., Wang, E.E.L., Feightner, J.W., Goldbloom, R., Elford, R.W. and Labrecque, M. (2000) Update on Preventive Health Care in 2000: Screening and Treatment of Hyperhomocysteinemia for the Prevention of Coronary Artery Disease. Canadian Medical Association Journal, 163, 21-29.
[27]  Nakbi, A., Koubaa, N., Ben Hamda, K., Hammami, S., Attia, N., Boumiza, R., et al. (2011) Association between the Parameters of the Oxidative Stress and the Markers of the Inflammation According to the Gravity of the Acute Coronary Syndrome. Tun Med, 89, 621-626.
[28]  Hansen, B. and Bruckert, E. (2010) Lipid Profile and Cardiovascular Risk in Patients with Rheumatoid Arthritis: Influence of Disease and Drug Therapy. Annales d’Endocrinologie, 71, 257-263.
[29]  Ratter, F., Gassner, C., Shatrov, V. and Lehmann, V. (2009) Modulation of Tumor Necrosis Factor-Alpha-Mediated Cytotoxicity by Changes of the Cellular Methylation State: Mechanism and in Vivo Relevance. International Immunology, 11, 518-527.
[30]  Jerbi, Z., Abdennebi, M., Douik, H., Ben Romdhane, H., Harzallah, L., Guemira, F., et al. (2005) Study of the C677T Polymorphism of the Methylene Tetrahydrofolate Reductase Gene in the Tunisian Population. Annales de Biologie Clinique, 63, 487-491.


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