Usually, meningiomas are benign neoplasms and their
malignant behavior is limited to local recurrence and brain invasion. The rate
of local recurrence increases according to histological grade as reported by
WHO criteria while extracranial metastases are rare. Anaplastic meningiomas
(AM) represent the most rare and aggressive subtype of all meningiomas. This tumor may progress from lower grade I or II meningiomas (secondary
AM) or develops as de novo disease (primary AM). We report a case of extracranial
metastatic progression of a heavily treated intracranial secondary anaplastic
meningioma. The metastatic progression was detected as unexpected and
unsuspected diagnosis because it occurred in absence of
local intracranial recurrence. There are no criteria to evaluate the risk for the
metastatic spread. In hindsight, a malignant progression in tumor histological
grade and a significant increase of ki-67 index represent useful predictors of
the aggressive behavior.
Cite this paper
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