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Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress

DOI: 10.4236/oalib.1102946, PP. 1-4

Subject Areas: Molecular Biology, Cell Biology, Genetics

Keywords: Genoautotomy, Programmed Genome “Self-Injury”, Genotoxic Stress, Single-Stranded DNA (ssDNA), Apoptosis, Autophagy, Anticancer Agent, Chloroquine

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This paper proposes that eukaryotic cells, under severe genotoxic stress, can commit genoautotomy (genome “self-injury”) that involves cutting and releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and leaving ssDNA gaps in the genome. The ssDNA gaps could be easily and precisely repaired later. The released ssDNA fragments may play some role in the regulation of cell cycle progression. Taken together, genoautotomy causes limited nonlethal DNA damage, but prevents the whole genome from lethal damage, and thus should be deemed as a eukaryotic cellular defence response to genotoxic stress.

Cite this paper

Li, G. (2016). Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress. Open Access Library Journal, 3, e2946. doi:


[1]  Maiuri, M.C., Zalckvar, E., Kimchi, A. and Kroemer, G. (2007) Self-Eating and Self-Killing: Crosstalk between Auto- phagy and Apoptosis. Nature Reviews Molecular Cell Biology, 8, 741-752.
[2]  Rubinstein, A.D. and Kimchi, A. (2012) Life in the Balance—A Mechanistic View of the Crosstalk between Autophagy and Apoptosis. Journal of Cell Science, 125, 5259-5268.
[3]  Li, G.D. (2016) A Possible Mechanism of DNA to DNA Transcription in Eukaryotic Cells: Endonuclease Dependent Transcript Cutout. Open Access Library Journal, 3, e2758.
[4]  Li, G.D. (2016) DNA to DNA Transcription Might Exist in Eukaryotic Cells. Open Access Library Journal, 3, e2665.
[5]  Clause, A.R. and Capaldi, E.A. (2006) Caudal Autotomy and Regeneration in Lizards. Journal of Experimental Zoology. Part A, Comparative Experimental Biology, 305, 965-973.
[6]  Fleming, P.A., Muller, D. and Bateman, P.W. (2007) Leave It All behind: A Taxonomic Perspective of Autotomy in Invertebrates. Biological Reviews of the Cambridge Philosophical Society, 82, 481-510.
[7]  Dickey, T.H., Altschuler, S.E. and Wuttke, D.S. (2013) Single-Stranded DNA-Binding Proteins: Multiple Domains for Multiple Functions. Structure, 21, 1074-1084.
[8]  Li, G.D. (2016) “Natural Site-Directed Mutagenesis” Might Exist in Eukaryotic Cells. Open Access Library Journal, 3, e2595.
[9]  Sch?rer, O.D. (2013) Nucleotide Excision Repair in Eukaryotes. Cold Spring Harbor Perspectives in Biology, 5, a012609.
[10]  Center, M.S. (1979) Induction of Single-Strand Regions in Nuclear DNA by Adriamycin. Biochemical and Biophysical Research Communications, 89, 1231-1238.
[11]  Carnevali, F. and Filetici, P. (1981) Single-Stranded Molecules in DNA Preparations from Cultured Mammalian Cells at Different Moments of Cell Cycle. Chromosoma, 82, 377-384.
[12]  Henson, P. (1978) The Presence of Single-Stranded Regions in Mammalian DNA. Journal of Molecular Biology, 119, 487-506.
[13]  Li, G.D. (2016) Certain Amplified Genomic-DNA Fragments (AGFs) May Be Involved in Cell Cycle Progression and Chloroquine Is Found to Induce the Production of Cell-Cycle-Associated AGFs (CAGFs) in Plasmodium falciparum. Open Access Library Journal, 3, e2447.
[14]  Kaina, B. (2003) DNA Damage-Triggered Apoptosis: Critical Role of DNA Repair, Double-Strand Breaks, Cell Proliferation and Signaling. Biochemical Pharmacology, 66, 1547-1554.
[15]  Nur-E-Kamal, A., Li, T.K., Zhang, A., Qi, H., Hars, E.S. and Liu, L.F. (2003) Single-Stranded DNA Induces Ataxia Telangiectasia Mutant (ATM)/p53 Dependent DNA Damage and Apoptotic Signals. Journal of Biological Chemistry, 278, 12475-12481.


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